A kind of isatidis plant protein or polypeptide and its extraction method and its application in antiviral drugs

A plant protein and Banlangen technology, applied in the field of medicine, can solve the problems of backward production technology, limited product promotion and application, unclear material basis and mechanism of action, etc., and achieve the effect of easy preparation and simple extraction method

Inactive Publication Date: 2016-04-27
SHENZHEN POLYTECHNIC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The composition of Radix isatidis is complex, its material basis and mechanism of action are not clear, the production process is still relatively backward, the production is in an extensive state, the product has low technological content, and the added value is not high, which limits the promotion and application of the product, and it is difficult to enter the international market

Method used

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  • A kind of isatidis plant protein or polypeptide and its extraction method and its application in antiviral drugs
  • A kind of isatidis plant protein or polypeptide and its extraction method and its application in antiviral drugs
  • A kind of isatidis plant protein or polypeptide and its extraction method and its application in antiviral drugs

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Embodiment Construction

[0046] The above-mentioned content of the present invention will be described in further detail below by the form of the embodiment, but this should not be interpreted as the scope of the above-mentioned theme of the present invention being limited to the following embodiments, all technologies realized based on the above-mentioned content of the present invention belong to scope of the invention.

[0047] see figure 1 , the embodiment of the present invention isatis root vegetable protein or polypeptide, its molecular weight is 15-50kDa (kilodalton), the purity reaches 50-90% (mass percentage), and it is obtained by purification from Radix isatidis. Among them, there are four bands of 15, 24, 26, and 34 KDa, 24 KDa is the band of trypsin, and the others are Radix isatidis protein or polypeptide.

[0048] The content (mass percentage) of plant protein or polypeptide in Radix Radix is ​​determined by BCA method (bicinchoninic acid).

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Abstract

The present invention provides isatidis plant protein or polypeptide and its extraction method and its application in antiviral drugs. By pulverizing the Radix Radix medicinal material, soaking the crushed Radix Radix medicinal material with deionized water for several hours and centrifuging, and passing the clear liquid through ultrafiltration Membrane ultrafiltration and then freeze-drying can obtain the crude protein or polypeptide of Radix isatidis with a molecular weight of 15-50kDa, and it is detected that the crude protein or polypeptide is 50-90% of the mass percentage of Radix isatidis. The above-mentioned isatidis plant protein or polypeptide is used for preparing antiviral drugs for preventing and treating viral diseases, inflammation and improving immunity.

Description

technical field [0001] The invention relates to a kind of vegetable protein extracted from Radix Radix Radix of traditional Chinese medicine, its extraction method and its application in antiviral drugs, belonging to the technical field of medicine. Background technique [0002] In recent years, SARS, bird flu, and influenza A H1N1 have frequently broken out in my country and even the world, causing great damage to human life and social economy. [0003] Vaccines have long been used to prevent viruses with good results, but vaccines are only effective if they match the subtype of the virus. Viruses mutate rapidly and outbreaks are unpredictable, while vaccine research and production are relatively lagging behind. [0004] In response to this drawback of the vaccine, people began to extensively study antiviral drugs to fight the virus. Western antiviral drugs have the characteristics of quick effect, high curative effect, and accurate action, but each type of drug is target...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/415C07K1/36C07K1/34C07K1/30C07K1/18A61K38/16A61P31/12A61P31/14A61P31/16A61P29/00A61P37/04
CPCA61K38/00C07K14/415
Inventor 刘西京
Owner SHENZHEN POLYTECHNIC
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