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Natural pharmaceutical composition and preparation method thereof

A technology of natural medicines and compositions, applied in the directions of drug combinations, pharmaceutical formulations, antitumor drugs, etc., can solve problems such as malnutrition, dehydration of patients, acid-base balance disorders, etc., and achieve high industrial practicability, convenient access, and synergistic effects. obvious effect

Inactive Publication Date: 2014-04-02
张宗升
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, with the advent and popularization of chemotherapy drugs such as 5-fluorouracil, taxanes, hydroxycamptothecin, irinotecan, Xeloda, etc., the incidence of chemotherapy-related diarrhea has increased year by year. Treatment can easily lead to dehydration, malnutrition, serum electrolyte disorder, acid-base balance disorder, etc., which not only bring great disadvantages to the recovery of the body, but also bring certain difficulties to periodic chemotherapy. Effective treatment has become an important part of the overall treatment of cancer patients
[0003]Chemotherapy-associated diarrhea, in terms of its clinical manifestations, belongs to the category of "diarrhea" in traditional Chinese medicine. The research on diarrhea in traditional Chinese medicine is remarkable, but at present There is no Chinese patent medicine that has the effect of alleviating diarrhea against cancer chemotherapy

Method used

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  • Natural pharmaceutical composition and preparation method thereof

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Embodiment approach

[0031] The first step: preparation of various extracts

[0032] (1) Preparation of Coptidis Radix Seeds Decoction Concentrated Extract

[0033] According to the compatibility ratio of 1-4:1, take coptis and radish seeds, soak in distilled water, heat and decoct, filter, add distilled water to the dregs, soak, decoct, and filter in the same way, mix the two filtrates, heat and concentrate, and ultrafilter Membrane filtration, drying under reduced pressure, that is.

[0034] (2) Preparation of berberine

[0035] Coptis rhizome is crushed, add ethanol, heat and reflux in water bath for 0.5h, suction filter, repeat the above operation twice for the filter residue, combine the filtrate, recover ethanol under reduced pressure, then add 1% acetic acid to heat and dissolve, suction filter, add concentrated hydrochloric acid dropwise to the filtrate until cloudy , cooling, that is, the berberine hydrochloride with yellow needles precipitated, suction filtered, washed twice with ice w...

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Abstract

The invention relates to a natural pharmaceutical composition and a preparation method thereof. The natural pharmaceutical composition is prepared from a decocted and concentrated coptis chinensis and semen raphani extract, berberine and sulforaphane according to the ratio of (2-7): (3-6): (3-7). The composition has a curative effect on treating diarrhea related to cancer chemotherapy.

Description

technical field [0001] The present invention relates to a natural medicinal composition, more specifically to a natural medicinal composition composed of the concentrated extract of Coptidis Rhizoma Radix, berberine and radish, the preparation method of the natural medicinal composition and the natural medicinal composition. Use of the pharmaceutical composition in preparing medicines for reducing cancer chemotherapy-associated diarrhea. Background technique [0002] Malignant tumor is one of the main diseases that endanger human survival and health at present. Its treatment methods include surgery, chemotherapy, radiotherapy, and traditional Chinese medicine treatment, and the effect of chemotherapy on tumors is particularly prominent. Chemotherapy drugs are cytotoxic anti-tumor drugs, which can cause diarrhea and other side effects when used alone or in combination. Diarrhea after tumor chemotherapy is also called chemotherapy-associated diarrhea. In recent years,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61P35/00A61P1/12A61K31/4375
Inventor 张宗升
Owner 张宗升