Application of medlar polysaccharide to resistance to sleep deprivation stress damage

A technology of Lycium barbarum polysaccharide and sleep deprivation, which is applied in the field of application of Lycium barbarum polysaccharide in the preparation of anti-sleep deprivation stress injury drugs, can solve problems not related to the application of Lycium barbarum polysaccharide, and achieve the effect of reducing physical function damage and improving the body condition

Active Publication Date: 2014-04-02
MILITARY ECONOMIC COLLEGE PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prior art does not relate to the application of Lyci

Method used

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  • Application of medlar polysaccharide to resistance to sleep deprivation stress damage
  • Application of medlar polysaccharide to resistance to sleep deprivation stress damage
  • Application of medlar polysaccharide to resistance to sleep deprivation stress damage

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0024] Example 1:

[0025] The effect of Lycium barbarum polysaccharides against sleep stress damage. A modified multi-platform water environment sleep deprivation method was used to establish a rat sleep deprivation model. After applying this model, it was found that the Lycium barbarum polysaccharide of the present invention has a certain effect on the body function of rats under sleep deprivation. The adjustment effect.

[0026] 1. Experimental animals

[0027] SD male Jiankang rats, 11-14 weeks old, weighing 200±20g.

[0028] 2. Main instruments and reagents

[0029] Sleep deprivation box

[0030] Lycium barbarum polysaccharide

[0031] Digital display constant temperature water bath

[0032] Electronic balance

[0033] SYMELGY HT multifunctional microplate reader

[0034] Superoxide dismutase (SOD) assay kit

[0035] Malondialdehyde (MDA) determination kit

[0036] Glutathione (GSH-ST) Assay Kit

[0037] Cortisol determination kit

[0038] Coomassie brilliant blue protein determination ki...

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Abstract

The invention relates to the technical field of biology, and discloses an application of medlar polysaccharide to preparation of drugs for resisting sleep deprivation stress damage; by studying effects of medlar polysaccharide on various liver indexes, serum epinephrine (EPI) and learning memory of sleep-deprived rats, the invention demonstrates that medlar polysaccharide has certain effects on regulating body functions. The invention has certain application prospects in the aspect of improvement of body conditions of personnel under continuous working process.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the application of Lycium barbarum polysaccharide in the preparation of anti-sleep deprivation stress injury medicine. Background technique [0002] Lycium barbarum is a traditional precious Chinese medicinal material in my country, known as "Red Treasure", rich in plant polysaccharides, protein, vitamins and other nutrients. Lycium barbarum polysaccharide (scientific name Lycium barbarum) is a water-soluble polysaccharide extracted from wolfberry. Existing studies have confirmed that the Lycium barbarum polysaccharide is a rare protein-containing polysaccharide among plant polysaccharides. It has six hexoses (rhamnose, arabinose, xylose, mannose, galactose, glucose) and The main chain of protein composed of 18 kinds of amino acids is connected in the way of Glycan-O-Der. This glycoprotein has biological activity and is a high-strength immune enhancer. Modern medical research belie...

Claims

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Application Information

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IPC IPC(8): A61K38/00A61K31/715A61P39/00A61P25/00
Inventor 李晓莉邵剑钢张锐军刘冬松陈松
Owner MILITARY ECONOMIC COLLEGE PLA
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