An implant material that solidifies prf precursor fluid into a gel film

A technology for implant materials and gel films, which is applied in the field of implant materials and implant materials for skin and mucous membrane surgery. It can solve the problems of high risk in the use of biological agents and complicated operations, and achieve the effects of strong tension, simple operation, and high hardness.

Active Publication Date: 2015-08-05
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide an implant material in which the PRF precursor fluid is solidified into a gel film in order to solve the defects of high risk of use of biological agents, rapid degradation, and complicated operation in the existing bone material technology.

Method used

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  • An implant material that solidifies prf precursor fluid into a gel film
  • An implant material that solidifies prf precursor fluid into a gel film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Collect 4ml of non-anticoagulated blood sample with a vacuette tube without any biological agent, immediately put it into a centrifuge (Anke TDL-80-2D China), adjust the centrifugal force at 130g, and centrifuge for 4 minutes; take out the stratified blood sample, the upper layer It is a turbid light yellow liquid, the lower layer is the red blood cell layer, and the middle buffy coat layer is very unclear; transfer the entire upper layer of turbid light yellow liquid into a ceramic double dish and mix well; let it stand at room temperature for about 30 minutes, and all the yellow liquid stops, and the liquid becomes In a turbid solid state, flatten it with a metal plate to prepare a film; pick it up with tweezers, and it has elasticity, toughness and hardness.

Embodiment 2

[0028] Collect 4ml of non-anticoagulated blood sample with a vacuette tube that does not contain any biological agents, immediately put it into a centrifuge (Anke TDL-80-2D China), adjust the centrifugal force at 270g, and centrifuge for 3 minutes; take out the stratified blood sample, the upper layer It is a turbid light yellow liquid, the lower layer is the red blood cell layer, and the middle buffy coat layer is very unclear; transfer the entire upper layer of turbid light yellow liquid into a ceramic double dish and mix well; let it stand at room temperature for 30 minutes, all the yellow liquid stops, and the liquid becomes turbid Solid state, flattened with a metal plate to prepare a film; clamped with tweezers, elastic, tough and hard, not easy to break when torn

Embodiment 3

[0030] Collect 4ml of non-anticoagulated blood sample with a vacuette tube without any biological agent, immediately put it into a centrifuge (Anke TDL-80-2D China), adjust the centrifugal force at 390g, and centrifuge for 2 minutes; take out the stratified blood sample, the upper layer It is a turbid light yellow liquid, the lower layer is the red blood cell layer, and the middle buffy coat layer is very unclear; transfer the entire upper layer of turbid light yellow liquid into a ceramic double dish and mix well; let it stand at room temperature for 35 minutes, all the yellow liquid stops, and the liquid becomes turbid Solid state, flattened with a metal plate to form a film; clamped with tweezers, it has elasticity, toughness and hardness, and is not easy to break when torn.

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PUM

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Abstract

The invention relates to an implant material with a PRF (Platelet-Rich Fibrin) precursor liquid solidified into a gel mask, and belongs to the field of the implant materials for mucocutaneous operations. The implant material provided by the invention is characterized in that a non-anti-coagulation blood sample is employed, and centrifuged by a centrifuge with centrifugal force ranging from 130 to 460g, the upper total yellow liquid is put into standing at the room temperature for 30-40 minutes, and then the total yellow liquid is pressed into a mask for clinical application by a metal pressing plate. The implant material provided by the invention is high in yield, and can be naturally formed into gel without adding thrombin and calcium ions; as a result, the use risk of biochemical preparations is avoided; the operation of the implant material is simple; the PRF gel product is thick in fibrous protein filaments, good in elasticity and tenacity, strong in tension, high in hardness, slow in degradation, and not easy to break by tearing; almost no damage is caused in the preparation process of hemameba, blood platelet and shed particles of the two; and after being implanted in vivo, the implant material slowly releases various growth factors and anti-inflammatory cytokines to promote wound healing.

Description

technical field [0001] The invention relates to an implant material in which PRF precursor fluid is solidified into a gel film, and belongs to the field of implant materials for skin and mucous membrane surgery. Background technique [0002] The basic process of skin and mucous membrane wound healing: the first process of inflammatory response, the early stage is mainly neutrophils, and after 3 days, it is macrophages, and the fibrinogen in the blood and exudate in the wound quickly coagulates to form a fibrin clot , the clot protects the wound. In the second process, the wound shrinks, and after 2-3 days, the whole layer of skin, mucous membrane and subcutaneous tissue on the edge move to the center, so the wound shrinks rapidly, until it stops around 14 days. The third process is granulation tissue hyperplasia and scar formation. About 3 days later, granulation tissue begins to grow from the bottom and edge of the wound to fill the wound. From 5-6 days, fibroblasts produ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/54
Inventor 陈智滨栾庆先刘凯宁
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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