6 results about "Protein filament" patented technology

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for computationally docking a small molecule or ligand to a prion-protein In one aspect, a system comprises receiving data comprising a structure of a candidate drug, a structure of a prion-protein filament comprising one or more prions, and a location of a binding site in the prion-protein filament structure, generating a plurality of stacked pose configurations of the candidate drug using at least the candidate drug structure, determining a corresponding docking score for each stacked pose configuration in the plurality of stacked pose configurations in accordance with a measure of a likelihood of binding for the stacked pose configuration in the location of the binding site in the prion-protein filament, and taking an action based on the corresponding docking scores.

The invention discloses a hydrogel composite scaffold as well as a preparation method and application thereof. The hydrogel composite scaffold comprises a hydrogel matrix and drug-loaded microspheres loaded on the hydrogel matrix, the hydrogel matrix is grafted with a photosensitive group; the drug-loaded microsphere comprises a microsphere matrix and a drug loaded on the microsphere matrix; the hydrogel matrix and the microsphere matrix respectively and independently comprise natural protein and derivatives thereof; the natural protein and the derivative thereof comprise at least one of silk fibroin, sericin, collagen or gelatin. According to the invention, the natural protein and the derivative thereof are grafted and modified by adopting a photosensitive group, so that the injectable property can be realized, and the formed hydrogel matrix has good biological activity, can promote adhesion and proliferation of cells, and is combined with the drug-loaded microspheres to realize controlled release of drugs and promote regeneration and repair of damaged tissues. The hydrogel composite scaffold can be widely applied to preparation of biomedical materials, in particular to preparation of cartilage repair materials.

This invention belongs to the field of cosmetic technology, specifically disclosing a multi-protein synergistic firming, anti-wrinkle, soothing, and repairing cosmetic composition, its preparation method, and its application. The cosmetic composition, by weight, is prepared from the following raw materials: 0.001-0.1 parts of Ma Yinglong Babao raw powder, 0.01-5 parts of oat firming protein, 0.01-1 part of silk protein, 0.001-0.1 parts of recombinant collagen, 0.001-0.1 parts of recombinant fibronectin, and 0.0001-0.1 parts of recombinant mussel protein. This invention utilizes the precise combination of oat firming protein, silk protein, recombinant collagen, recombinant fibronectin, recombinant mussel protein, and Ma Yinglong Babao raw powder to construct a four-in-one efficacy system of "firming-anti-wrinkle-soothing-repairing," achieving synergistic effects among the proteins. This solves the problems of existing products having single efficacy, poor synergy, and easy skin irritation, providing a highly effective and gentle comprehensive care solution for aging skin, sensitive skin, and skin with damaged skin barriers.

The application discloses a kind of for tissue adhesion and repair mussel biomimetic flexible sustained-release gel film, including flexible sustained-release gel film matrix and active ingredient loaded in the matrix.The flexible sustained-release gel film matrix is composed of mussel extraction protein, silk fibroin, collagen, crosslinking agent, gold yellow chamomile vesicle-phospholipid complex, deionized water;The active ingredient is composed of sandalwood essential oil, tea tree essential oil, ekdoine, dextran.The application adopts mussel extraction protein, silk fibroin and collagen compound as matrix, adopts gold yellow chamomile vesicle-phospholipid complex as carrier material, and is prepared by specific crosslinking agent, and the gel film obtained has excellent wet-state adhesive property, good mechanical property and biocompatibility, can realize the sustained slow release of active ingredient, effectively promote the repair and regeneration of skin tissue, and can be widely applied in wound dressing, medical instrument coating, tissue engineering scaffold and other fields.

The application provides a coconut cream and a preparation method thereof, and the coconut cream comprises the following raw materials in parts by weight: 90-110 parts of coconut oil, 0.5-0.8 parts of microcrystalline cellulose, 0.1-0.3 parts of sodium carboxymethyl cellulose, 0.20-0.70 parts of a colloid and 2-5 parts of protein; the colloid is at least one of xanthan gum, carrageenan or guar gum; and the protein is at least one of coconut meat protein, casein protein, silk fibroin, soybean protein isolate or whey protein. The coconut cream is prepared by taking pure coconut oil as a main raw material, taking microcrystalline cellulose and xanthan gum as additives and combining silk fibroin, soybean protein isolate and whey protein, and the coconut cream has the advantages of stable structure network, good low-temperature storage property, high whipping rate and hardness, no whey leakage rate, good smearing property and excellent piping performance.

This invention discloses a freeze-thaw stable plant-based meat and its preparation method, belonging to the technical field of plant-based meat products. The invention prepares plant-based meat through the following steps: S1. Modifying plant protein to obtain modified plant protein, wherein the modification involves adding PG enzyme during the neutralization stage of plant protein extraction followed by puffing; S2. Debonding textured protein to obtain textured protein strands; S3. Mixing the modified plant protein, textured protein strands, antifreeze protein, antifreeze colloid, antifreeze starch, and water evenly, followed by steaming. This invention utilizes enzymatic modification of plant protein synergistically with puffing treatment, combined with a triple antifreeze compound system consisting of antifreeze protein, antifreeze colloid, and antifreeze starch, enabling the plant-based meat to maintain excellent water retention and textural stability during long-term freeze-thaw cycles, significantly reducing the thawing water separation rate, while possessing a fibrous texture and chewiness close to real meat, making it suitable for frozen storage and cold chain transportation.