13 results about "Protein filament" patented technology

The invention relates to the technical field of textile, and particularly discloses a low-wear protein silk fabric production process, which comprises the following steps: step 1, preparing yarns, warp yarns and weft yarns being 1 / 50D / 48F semi-gloss polyester T-800; step 2, yarn treatment: warp treatment: grey yarn, sectional warping and drafting and reed digging are performed, and weft yarns do not need to be treated; step 3, weaving: weaving by adopting a plain weave, and interweaving by using a water-jet loom to obtain a finished product fabric; step 4, inspection: inspecting the finished fabric, and leaving the factory after the finished fabric is inspected to be qualified; in the sectional warping process in the step 2, a sectional warping machine is used, the two processes of reeling and two-for-one twisting are omitted during warp processing, the warp sectional warping process is optimized, broken filaments are effectively prevented, and the finished fabric is compact in texture and has a certain decorous feeling; by optimizing the weaving process, the phenomena of weft breakage, weft carrying, warp breakage and the like can be effectively reduced in the weaving process, and the finished fabric is soft, comfortable, easy to form and good and soft in hand feeling.

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for computationally docking a small molecule or ligand to a prion-protein In one aspect, a system comprises receiving data comprising a structure of a candidate drug, a structure of a prion-protein filament comprising one or more prions, and a location of a binding site in the prion-protein filament structure, generating a plurality of stacked pose configurations of the candidate drug using at least the candidate drug structure, determining a corresponding docking score for each stacked pose configuration in the plurality of stacked pose configurations in accordance with a measure of a likelihood of binding for the stacked pose configuration in the location of the binding site in the prion-protein filament, and taking an action based on the corresponding docking scores.

The invention discloses a hydrogel composite scaffold as well as a preparation method and application thereof. The hydrogel composite scaffold comprises a hydrogel matrix and drug-loaded microspheres loaded on the hydrogel matrix, the hydrogel matrix is grafted with a photosensitive group; the drug-loaded microsphere comprises a microsphere matrix and a drug loaded on the microsphere matrix; the hydrogel matrix and the microsphere matrix respectively and independently comprise natural protein and derivatives thereof; the natural protein and the derivative thereof comprise at least one of silk fibroin, sericin, collagen or gelatin. According to the invention, the natural protein and the derivative thereof are grafted and modified by adopting a photosensitive group, so that the injectable property can be realized, and the formed hydrogel matrix has good biological activity, can promote adhesion and proliferation of cells, and is combined with the drug-loaded microspheres to realize controlled release of drugs and promote regeneration and repair of damaged tissues. The hydrogel composite scaffold can be widely applied to preparation of biomedical materials, in particular to preparation of cartilage repair materials.

The invention relates to the technical field of vascular therapy, in particular to a nano-drug and a preparation method thereof.The nano-drug comprises a nano-carrier, a therapeutic drug and cross-linked protein are loaded on the nano-carrier, the cross-linked protein is at least partially loaded on the surface of the nano-carrier, and the cross-linked protein is at least one of silk fibroin, sericin and silk fibroin peptide; the therapeutic drug is at least partially loaded in the nano-carrier. On one hand, cross-linked protein on the surface of the nano-carrier is promoted to be cross-linked with protein in a blood vessel by initiating the photosensitive cross-linking agent, and the nano-carrier is anchored in the blood vessel, so that the risk that nano-drug particles are eluted from the blood vessel wall is greatly reduced; on the other hand, cross-linking of cross-linked protein on the surface of the nano-carrier can be promoted by initiating the photosensitive cross-linking agent, so that the surface of the nano-carrier is gelatinized, the slow release speed of the nano-drug anchored in the blood vessel is more lasting, and further effective drug concentration can be maintained for a long time, restenosis of the blood vessel is inhibited, and the treatment effect is improved.

The invention relates to the field of textile materials and biomass modification, and discloses a multi-performance synergistically modified human-simulated hair protein filament and a preparation process thereof, the preparation process comprises the following steps: raw material pretreatment: selecting an animal hair keratin fiber raw material, the animal hair keratin fiber raw material is one or more of yak hair, wool and horse hair, and the animal hair keratin fiber raw material is one or more of the yak hair, the wool and the horse hair; the raw materials are subjected to cleaning and degreasing treatment to remove oil stains and impurities, and then bleaching treatment is performed to reduce the natural color of the raw materials, so that the raw materials are easily endowed with a target color, and clean light-colored fibers are obtained. In a structural recombination pretreatment stage, the internal structure of the fiber is changed by utilizing a solvent, and the partially dissociated keratin provides a channel for subsequent permeation of a modifier, so that polyphenol molecules can penetrate into the fiber to be crosslinked with protein and form a stable complexing structure with protein molecules; therefore, the strength and the toughness of the fiber are enhanced, and the human hair-imitating protein filament prepared by the method has higher durability.

This invention belongs to the field of cosmetic technology, specifically disclosing a multi-protein synergistic firming, anti-wrinkle, soothing, and repairing cosmetic composition, its preparation method, and its application. The cosmetic composition, by weight, is prepared from the following raw materials: 0.001-0.1 parts of Ma Yinglong Babao raw powder, 0.01-5 parts of oat firming protein, 0.01-1 part of silk protein, 0.001-0.1 parts of recombinant collagen, 0.001-0.1 parts of recombinant fibronectin, and 0.0001-0.1 parts of recombinant mussel protein. This invention utilizes the precise combination of oat firming protein, silk protein, recombinant collagen, recombinant fibronectin, recombinant mussel protein, and Ma Yinglong Babao raw powder to construct a four-in-one efficacy system of "firming-anti-wrinkle-soothing-repairing," achieving synergistic effects among the proteins. This solves the problems of existing products having single efficacy, poor synergy, and easy skin irritation, providing a highly effective and gentle comprehensive care solution for aging skin, sensitive skin, and skin with damaged skin barriers.

The application discloses a kind of for tissue adhesion and repair mussel biomimetic flexible sustained-release gel film, including flexible sustained-release gel film matrix and active ingredient loaded in the matrix.The flexible sustained-release gel film matrix is composed of mussel extraction protein, silk fibroin, collagen, crosslinking agent, gold yellow chamomile vesicle-phospholipid complex, deionized water;The active ingredient is composed of sandalwood essential oil, tea tree essential oil, ekdoine, dextran.The application adopts mussel extraction protein, silk fibroin and collagen compound as matrix, adopts gold yellow chamomile vesicle-phospholipid complex as carrier material, and is prepared by specific crosslinking agent, and the gel film obtained has excellent wet-state adhesive property, good mechanical property and biocompatibility, can realize the sustained slow release of active ingredient, effectively promote the repair and regeneration of skin tissue, and can be widely applied in wound dressing, medical instrument coating, tissue engineering scaffold and other fields.

The invention discloses a standing wave feedback serum clot detection device and method, and belongs to the field of medical instruments, and the device comprises a probe tube which is provided with a working tail end and is of a hollow cylindrical structure; the oscillation starting wave emitter is connected with the inner wall of the exploring tube; the laser transmitter is provided with a second transmitting tail end, and when the laser transmitter is coaxially connected with the oscillation starting wave transmitter, the second transmitting tail end extends out of the working tail end; the photoelectric converter is connected with the inner wall of the probe tube and is aligned with the working tail end; in a working state, the oscillation starting wave emitter excites interference standing waves on the liquid level, the laser emitter emits laser to the liquid level, the photoelectric converter receives laser beams emitted to a standing wave area and reflected after the laser beams are emitted to the liquid level and forms electric signals, and when fibrin exists on the liquid level, liquid level tension is damaged, standing wave stability is affected, and fluctuation of the electric signals is abnormal. Through the arrangement, whether fibrous protein blocks or protein filaments exist on the surface of a blood sample or not can be judged.

The application provides a coconut cream and a preparation method thereof, and the coconut cream comprises the following raw materials in parts by weight: 90-110 parts of coconut oil, 0.5-0.8 parts of microcrystalline cellulose, 0.1-0.3 parts of sodium carboxymethyl cellulose, 0.20-0.70 parts of a colloid and 2-5 parts of protein; the colloid is at least one of xanthan gum, carrageenan or guar gum; and the protein is at least one of coconut meat protein, casein protein, silk fibroin, soybean protein isolate or whey protein. The coconut cream is prepared by taking pure coconut oil as a main raw material, taking microcrystalline cellulose and xanthan gum as additives and combining silk fibroin, soybean protein isolate and whey protein, and the coconut cream has the advantages of stable structure network, good low-temperature storage property, high whipping rate and hardness, no whey leakage rate, good smearing property and excellent piping performance.

This invention discloses a method for preparing and testing salmon emulsion gels that improve swallowing difficulties. It relates to the field of protein emulsion gel preparation and testing technology, addressing the problems of swallowing difficulties caused by protein-rich diets, insufficient intake of functional fatty acids in most elderly individuals, and the lack of a robust performance verification system for salmon emulsion gel products. At the molecular level, this invention transforms large-sized myofibril protein filament aggregates into nano-sized myofibril micelles. These nano-sized myofibril micelles dissociate in oil, linking and aggregating with other proteins. The molecular mechanism by which these micelles stabilize salmon emulsion gels and thicken their texture can be used to alter protein structure and self-assembly properties. Furthermore, it provides effective and comprehensive testing of salmon emulsion gel products, strongly demonstrating their effectiveness in improving swallowing difficulties.

The invention relates to the technical field of protein fibers, and provides high-strength bio-based protein silk and a preparation method thereof, and the high-strength bio-based protein silk is prepared by weaving imitated silk; the bio-based protein silk is prepared by weaving imitated silk; the imitated silk is prepared from the following components in parts by weight: 60-80 parts of polyvinyl alcohol, 45-60 parts of collagen, 1-3 parts of a cross-linking agent, 1-3 parts of a defoaming agent and 8-16 parts of an auxiliary A, the auxiliary agent A comprises the following components in parts by weight: 4-8 parts of titanium dioxide, 4-8 parts of mica and 1-2 parts of nicotinic acid compounds. According to the technical scheme, the problem that the bio-based protein silk in the prior art is low in strength is solved.

This invention discloses a freeze-thaw stable plant-based meat and its preparation method, belonging to the technical field of plant-based meat products. The invention prepares plant-based meat through the following steps: S1. Modifying plant protein to obtain modified plant protein, wherein the modification involves adding PG enzyme during the neutralization stage of plant protein extraction followed by puffing; S2. Debonding textured protein to obtain textured protein strands; S3. Mixing the modified plant protein, textured protein strands, antifreeze protein, antifreeze colloid, antifreeze starch, and water evenly, followed by steaming. This invention utilizes enzymatic modification of plant protein synergistically with puffing treatment, combined with a triple antifreeze compound system consisting of antifreeze protein, antifreeze colloid, and antifreeze starch, enabling the plant-based meat to maintain excellent water retention and textural stability during long-term freeze-thaw cycles, significantly reducing the thawing water separation rate, while possessing a fibrous texture and chewiness close to real meat, making it suitable for frozen storage and cold chain transportation.

The present invention relates to a method for producing an edible protein thread, the method comprising the steps of: - preparing a first composition (130), wherein said first composition comprises: animal protein, wherein the animal protein is derived from cultured non-human animal cells; and · either polyvalent ions or polyelectrolytes; - preparing a second composition (140), wherein said second composition comprises: the multivalent ions, if the step of preparing the first composition (130) includes the addition of the polyelectrolyte, or the polyelectrolyte, if the step of preparing the first composition (130) includes the addition of the multivalent ion; and - contacting (160) said first composition with said second composition to form edible protein threads, wherein said first composition has a temperature below 65°C.