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Multilayer bionic intestinal stent and preparation method thereof

A technology with a three-layer structure and intestinal tract, which is applied in the direction of stents, drug devices, and other medical devices, can solve the problems of secondary intestinal damage and high stress, and achieve simple operation, shortened operation time, easy learning and The effect of promotion

Inactive Publication Date: 2014-04-09
POLYU RES BASE SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solve the problem that traditional stents use metal alloy wires, and the stress is too large, causing secondary damage to the intestinal tract and many complications

Method used

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  • Multilayer bionic intestinal stent and preparation method thereof
  • Multilayer bionic intestinal stent and preparation method thereof
  • Multilayer bionic intestinal stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] 1. Preparation of scaffolds by knitting method;

[0065] 1) Bracket material;

[0066] A medical stent raw material, polymer monofilament, high modulus, strength, monofilament diameter about 0.1-0.6mm, tensile strength greater than 400N / mm 2 , The breaking strength is greater than 600MPa, the melting temperature is higher than 90°C, and the breaking elongation is less than 40%. The selected materials are polyglycolic acid, polyglycolic acid, polydioxanone, and polylactic acid-glycolic acid copolymer. Such as figure 2 , 3 , 4, the selected medical grade polymer in this embodiment has good flexural rigidity performance, and the maximum flexural rigidity is 0.8gf*cm 2 The maximum breaking strength reaches 37N, and the breaking elongation is 45%. The plastic performance test of the selected absorbable polymer monofilament shows that before breaking, the material has no obvious plastic deformation point and has good resistance to plastic deformation.

[0067] 2) Molding...

Embodiment 2

[0074] 1. Preparation of scaffolds by braiding method;

[0075] 1) Bracket material;

[0076] A medical stent raw material, polymer monofilament, high modulus, strength, monofilament diameter about 0.1-0.6mm, tensile strength greater than 400N / mm2, breaking strength greater than 600MPa, melting temperature higher than 90°C, elongation at break less than 40%, and the bioabsorption period is greater than 60 days. The selected materials are polyglycolic acid, polyglycolic acid, polydioxanone, polylactic acid-glycolic acid copolymer. Such as figure 2 , 3 , 4, the selected absorbable polymer in this embodiment has good flexural rigidity, the maximum flexural rigidity is 0.8gf*cm2; the maximum breaking strength reaches 37N, and the breaking elongation is 45%; the selected absorbable polymer The plasticity test of the silk shows that before breaking, the material has no obvious plastic deformation point and has good resistance to plastic deformation.

[0077] 2) Molding process;...

Embodiment 3

[0084] 1. Prepare the scaffold by weaving method;

[0085] 1) Bracket material;

[0086] A medical stent raw material, polymer monofilament, high modulus, strength, monofilament diameter about 0.1-0.6mm, tensile strength greater than 400N / mm 2 , The breaking strength is greater than 600MPa, the melting temperature is higher than 90°C, the elongation at break is less than 40%, and the bioabsorption period is greater than 90 days. The selected materials are polyglycolic acid, polyglycolic acid, polydioxanone, and polylactic acid-glycolic acid copolymer. Such as figure 2 , 3 , As shown in 4, the selected medical polymer has good flexural rigidity performance in this embodiment, and the maximum flexural rigidity is 0.8gf*cm 2 The maximum breaking strength reaches 37N, and the breaking elongation is 45%. The plastic performance test of the selected absorbable polymer monofilament shows that before breaking, the material has no obvious plastic deformation point and has good resi...

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Abstract

The invention relates to a multilayer bionic intestinal stent for treating intestinal diseases, belongs to biological medical textiles, and aims to overcome the defects that traditional metal intestinal stent is high in stress, causes intestinal tract secondary damage, cannot be directly used for treating intestinal diseased parts, and the like. The stent comprise at least three layers, the innermost layer 1 is a smooth medical polymer coating 0.05-0.25mm in thickness, the middle layer 2 is the tubular tent body, which is knitted and woven by medical polymer, with radial compression force of 30-240cN and a seamless tube wall structure, and the outermost layer 3 is a medicine film layer for treating the diseased parts. The stent has the advantages that the stent is excellent in mechanical performance and capable of realizing non-degradation, partial degradation and total degradation, degradation time is controllable, the pharmaceutical formulation of the outer layer is adjusted, and a mechanical model is built to allow the support force of the stent to be controllable.

Description

technical field [0001] The invention belongs to a special device in the field of biomedical textiles, and in particular relates to a multi-layer structure bracket for treating intestinal lesions obtained by using a textile design and processing method. Background technique [0002] Colorectal cancer, referred to as "CRC", is one of the diseases with the highest morbidity and mortality in the world today. Surgery is the most common method used to treat this disease. Such as enterostomy or laparotomy, resection of the tumor, and end-to-end anastomosis of the intestine. However, the recurrence rate and mortality rate caused by surgery are as high as 4%-60%, 8.8%-27%. In addition, some patients do not have the physiological and pathological conditions for laparotomy, such as the elderly, systemic metastasis of malignant tumors, and advanced cases. Therefore, in recent years, colorectal stent surgery is a widely adopted clinical program for such patients. Currently, the only ...

Claims

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Application Information

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IPC IPC(8): A61F2/90A61M31/00A61L27/54A61L27/40
Inventor 李翼李刚胡军岩兰平李加深胡红何小文张晶
Owner POLYU RES BASE SHENZHEN
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