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Toltrazuril alkali metal salt soluble powder and preparation method thereof

A technology of toltrazuril and alkali metal salts, applied in the field of toltrazuril alkali metal salt soluble powder and preparation thereof, can solve the problems of unfavorable toltrazuril raw material medicine production, transportation and use, as well as the inconsistency of mixing and administration methods. Convenience, inaccurate dosage, etc

Active Publication Date: 2014-04-09
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, toltrazuril is insoluble in water, and it is usually administered with a premixed agent. Due to the particularity of the feeding habits of chickens, the method of administering the agent is not only inconvenient, but also difficult to mix with the feed, resulting in drug administration. Inaccurate dosage will also cause serious waste of medicine
Not only that, but the toltrazuril raw material also has the problems of poor stability and strong hygroscopicity, which makes the toltrazuril raw material prone to failure in a short period of time, which is not conducive to the production, transportation and use of toltrazuril raw material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1) Weigh 2.5% toltrazuril potassium salt, 0.1% anhydrous calcium chloride and 97.4% lactose according to the composition ratio of toltrazuril potassium salt soluble powder;

[0019] 2) Adding the taken components into a mixer and mixing evenly to obtain toltrazuril potassium salt soluble powder.

Embodiment 2

[0021] 1) Weigh 50% toltrazuril potassium salt, 3% ammonium chloride and 47% sucrose according to the composition ratio of toltrazuril potassium salt soluble powder;

[0022] 2) Adding the taken components into a mixer and mixing evenly to obtain toltrazuril potassium salt soluble powder.

[0023] Stability Test of Toltrazuril Potassium Salt Soluble Powder

[0024] According to the requirements of the "Technical Specifications for Stability Test of Veterinary Drugs", under the accelerated stability test conditions, the stability of the toltrazuril potassium salt soluble powder prepared in Example 2 was tested.

[0025] Test method: Put the soluble powder of tortrazuril potassium salt prepared in Example 2 in the SHH-250SD drug stability test box (Chongqing Yongsheng Experimental Instrument Factory), at a temperature of 40 ° C ± 2 ° C, a relative humidity of 75% ± Place it under the condition of 5% for 6 months, take samples once in 0, 1, 2, 3, and 6 months respectively, condu...

Embodiment 3

[0031] 1) Weigh 30% of toltrazuril sodium salt, 1% of hydrogenated tallow primary amine and 69% of glucose according to the composition ratio of toltrazuril sodium salt soluble powder;

[0032] 2) Adding the taken components into a mixer and mixing evenly to obtain toltrazuril sodium salt soluble powder.

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PUM

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Abstract

The invention discloses toltrazuril alkali metal salt soluble powder and a preparation method thereof. The soluble powder comprises the following components in percentage by mass: 2.5-50% of toltrazuril alkali metal salt, 0.1-3% of anti-caking agent and 47-97.4% of water soluble diluent. The preparation method of the soluble powder comprises the following steps: weighing the toltrazuril alkali metal salt, an anti-caking agent and a water soluble diluent according to the component proportion of the toltrazuril alkali metal salt soluble powder; and mixing the weighed components uniformly to obtain the toltrazuril alkali metal salt soluble powder. With the toltrazuril alkali metal salt as the main component, the soluble powder is soluble in water with high stability and low hygroscopicity, and is used for treating and preventing coccidiosis of chicken; the curative effect is remarkable, and the administration is convenient; the administration dosage can be accurately controlled according to the condition of the animal; and the coccidiosis of the animal can be quickly and accurately prevented and treated, and the waste of drug in the administration process can be avoided. The preparation method of the soluble powder is simple, and the cost is low.

Description

technical field [0001] The invention relates to a soluble powder of toltrazuril alkali metal salt and a preparation method thereof, belonging to the field of veterinary medicines. Background technique [0002] Chicken coccidiosis is a chicken parasitic disease caused by Eimeria coccidiosis. Most of them break out in young animals, and the mortality rate is as high as 30%. It is currently the most harmful parasitic disease to the chicken industry. There is no cross-immunity between the various species of Eimeria, and it is easy to break out coccidiosis caused by different species. [0003] At present, toltrazuril raw materials are mainly used to prevent and treat chicken coccidiosis infection. Toltrazuril is referred to as methyl triazone for short. Toltrazuril has a wide range of action sites on coccidia, and has a good spectral anticoccidial effect. However, toltrazuril is insoluble in water, and it is usually administered with a premixed agent. Due to the particularity o...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/53A61K47/26A61K47/10A61P33/02
Inventor 王铭宏汪敦辉
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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