A kind of nighting capsule and preparation method thereof

A technology of capsules and nighting, which is applied in capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients. High resistance to moisture absorption and shortening of process time

Active Publication Date: 2015-12-30
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation method has disadvantages: first, the extraction cycle of the ethanol extract of Ganoderma lucidum is long, and the ethanol concentration and dosage are not clear; second, the temperature soaking process conditions of floating wheat are still unclear
[0004] Disclosed in Chinese patent application CN01102093.8 is a kind of nano night ning preparation medicine and preparation method thereof, after this method first makes each flavor medicine respectively after the nano-scale granule, and then according to " Chinese Pharmacopoeia " night ning syrup original prescription ratio Made into various preparations, but there is no exact record of drug efficacy in the application, which has been withdrawn at present
[0005] Chinese Patent No. 200410041958.1 discloses a preparation method of nighting medicine and its solid preparation. In this method, the amount of water is limited when the floating wheat is soaked in temperature; Corresponding restrictions have also been made; the separate spray drying of Ganoderma lucidum alcohol extract avoids the uneven distribution of alcohol-soluble parts and water-soluble parts in the extract during the concentration process, thereby affecting the quality of the drug. It is scientific to a certain extent, but it also has shortcomings: ①The warm soaking process of floating wheat requires a large amount of water, which increases the heating time; ②When extracting Ganoderma lucidum with alcohol, the concentration of ethanol is low, and the content of alcohol extract is not high; ③The floating wheat and (Ganoderma lucidum residue and other traditional Chinese medicine extract ) There are still uncertainties in the combined concentration and spray drying; ④ There are uncertainties in the treatment of spray-dried powders in making solid preparations; ⑤ Butanol extract is low
[0006] The original dosage form of Yening is syrup, which tastes bad and is inconvenient to take, especially compared to those who are sensitive to taste, it is even more unfavorable to take; adding a large amount of sucrose as an auxiliary material affects the taking of diabetic patients; Susceptible to contamination during the process

Method used

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  • A kind of nighting capsule and preparation method thereof
  • A kind of nighting capsule and preparation method thereof
  • A kind of nighting capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Weigh 0.84kg of Albizia Julibrissin, 0.4kg of Ganoderma lucidum, 0.84kg of Shouwu vine, 0.6kg of Chinese jujube, 0.84kg of Ligustrum lucidum, 0.24kg of licorice, and 1.4kg of floating wheat.

[0034] (1) Nano-grind Ganoderma lucidum and floating wheat, and pass through a 120-mesh sieve for later use.

[0035] (2) Add 6 times the weight of the medicinal materials in water to the rest of the Chinese herbal medicines (Albizia chinensis, Shouwu vine, jujube, Ligustrum lucidum, licorice), and decoct twice at 70°C (6 times the amount of water each time), 3 times each time. hours, combine the extracts for later use, discard the dregs, filter, and concentrate the filtrate under reduced pressure at a temperature of 65°C and a vacuum of -0.084MPa to an extract with a relative density of 1.08. Spray drying under the condition of 90°C to prepare the extract powder.

[0036] (3) Mix ganoderma lucidum, floating wheat and extract powder evenly, dry granulate, sieve, put the granules ...

Embodiment 2

[0038] Weigh 1.68kg of Albizia Julibrissin, 0.8kg of Ganoderma lucidum, 1.68g of Shouwu vine, 1.2kg of jujube, 1.68kg of Ligustrum lucidum, 0.48kg of licorice, and 3.8kg of floating wheat.

[0039] (1) Nano-grind Ganoderma lucidum and floating wheat, and pass through a 120-mesh sieve for later use.

[0040] (2) Add the remaining Chinese herbal medicines (Acacia Albizia, Shouwu, Jujube, Ligustrum lucidum, Licorice) to 8 times the weight of the medicinal materials in water, decoct twice at 73°C for 3 hours each time, and combine the extracts for later use. The slag was discarded, filtered, the filtrate was concentrated under reduced pressure at a temperature of 67°C and a vacuum of -0.084MPa to an extract with a relative density of 1.08, and the extract was spray-dried under the conditions of an inlet air temperature of 150°C and an outlet air temperature of 100°C , to prepare the extract powder.

[0041] (3) Mix ganoderma lucidum, floating wheat and extract powder evenly, dry ...

Embodiment 3

[0043] Weigh 2.52kg of Albizia Julibrissin, 1.2kg of Ganoderma lucidum, 2.52g of Shouwu vine, 1.8kg of Chinese jujube, 2.52kg of Ligustrum lucidum, 0.72kg of licorice, and 6.2kg of floating wheat.

[0044](1) Nano-grind Ganoderma lucidum and floating wheat, and pass through a 120-mesh sieve for later use.

[0045] (2) The rest of the Chinese herbal medicines (Acacia barbadensis, Shouwu vine, jujube, Ligustrum lucidum, licorice) are added to 10 times the weight of the medicinal materials in water, decocted twice at 80°C for 3 hours each time, and the extracts are combined for later use. The slag was discarded, filtered, the filtrate was concentrated under reduced pressure at a temperature of 69°C and a vacuum of -0.088MPa to an extract with a relative density of 1.08, and the extract was spray-dried under the conditions of an inlet air temperature of 160°C and an outlet air temperature of 110°C , to prepare the extract powder.

[0046] (3) Mix ganoderma lucidum, floating wheat...

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Abstract

The invention discloses a Yening capsule and a preparation method thereof. The adopted method is to carry out superfine grinding on lucid ganoderma and blighted wheat, thereby avoiding single extraction of the two medicines in the traditional process, shortening the process time and better playing efficacy; dry granulation is adopted to avoid the defect that a large amount of excipients are added in the granulation process and greatly decrease the taking dosage, so as to ensure easier acceptance and convenience in taking of patients; furthermore, the powder fluidity is improved, the resistance to moisture absorption is increased, the storage is easy, bad smell can be hidden, taking is more convenient, the property is more stable, storage, carrying and transportation are easy, and meanwhile, taking requirements of diabetic patients are satisfied.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a nighting capsule and a preparation method thereof. Background technique [0002] Existing nighting preparations are generally made from the seven traditional Chinese medicines of Albizia Julibrissin, Shouwu vine, Ganoderma lucidum, jujube, licorice, privet lucidum, and floating wheat. The main function is to calm the nerves and nourish the heart, and is used for neurasthenia, headache The treatment of sleep disorders caused by factors such as dizziness, insomnia, blood deficiency and dreaminess, etc., has an exact and reliable effect. [0003] The preparation method of the nighting syrup recorded in the 2000 edition of the "Chinese Pharmacopoeia" is: after the floating wheat is boiled with water, soak twice at 80-90°C for 2 hours each time, and combine the soaking liquid; crush the ganoderma lucidum into coarse powder , soaked in an appropriate amount o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/899A61P25/20
Inventor 刘全国陈克领林文君
Owner HAINAN HULUWA PHARMA GRP CO LTD
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