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Sini decoction refined total alkaloid for preventing and treating heart diseases and application thereof

A technology of total alkaloids and Sini decoction, which is used in medical preparations containing active ingredients, cardiovascular system diseases, drug combinations, etc., to achieve the effects of low adverse reactions, good heart, and prevention of myocardial cell damage

Inactive Publication Date: 2014-04-23
孟永海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are a lot of research and reports on ingredients, pharmacological effects and clinical application of the three traditional Chinese medicines in the prescription, but there must be changes in the "quality" and "quantity" of the extracted substances in the compatibility and application of the prescriptions, and these changes are most likely to be the key substances of the efficacy

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  • Sini decoction refined total alkaloid for preventing and treating heart diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A refined total alkaloid of Sini decoction with the effect of preventing and treating heart disease, which is prepared by the following method:

[0029] (1) Take a total of 2.0kg of the original medicinal materials of Sini Decoction according to the compatibility of aconite-dried ginger-roasted licorice (3:2:3), add 10 times the weight of water to decoct twice, extract for 2 hours each time, and concentrate the filtrate to After the density is 1.18g / mL, add 95% ethanol until the ethanol concentration is 80%, and let stand for 12 hours.

[0030] (2) Add a certain amount of water to the supernatant to recover ethanol under reduced pressure and disperse it to 8L, then put it on the DM-301 macroporous adsorption resin column. Then use concentration to be 30% ethanol 5kg elution, 50% ethanol 4kg elution, 70% ethanol 2kg elution, 95% ethanol 6kg elution, after checking each elution component alkaloid, the combined concentration is 30% and 95% ethanol eluent;

[0031] (3) Ta...

Embodiment 2

[0034] A refined total alkaloid of Sini decoction with the effect of preventing and treating heart disease, which is prepared by the following method:

[0035] (1) Take the original medicinal materials of Sini Decoction according to the compatibility of aconite-dried ginger-roasted licorice (3:2:3) for a total of 10.0kg, add 8 times the weight of water to decoct 3 times, extract for 2 hours each time, and concentrate the filtrate to After the density is 1.2g / mL, add 95% ethanol until the ethanol concentration is 60%, and let stand for 24 hours.

[0036] (2) Add a certain amount of water to the supernatant to recover ethanol under reduced pressure and disperse it to 40L, then put it on the HPD-100 macroporous adsorption resin column. It is 21kg; then use concentration to be 30% ethanol 25kg elution, 50% ethanol 20kg elution, 70% ethanol 10kg elution, 95% ethanol 30kg elution, after checking each elution component alkaloid, the combined concentration is 30% and 95% ethanol elue...

Embodiment 3 4

[0039] Example 3 Experiment of the protective effect of the refined total alkaloids of Sini decoction on cardiomyocytes induced by doxorubicin.

[0040] Take ICR male mice and divide them into random groups, 10 mice / group. The normal group was intraperitoneally injected with 0.2mL normal saline; the adriamycin model group was injected intraperitoneally with adriamycin (20mg / kg); extract, concentrated to extract); Sini decoction decoction group (take the original medicinal materials of Sini decoction according to the compatibility of aconite-dried ginger-roasted licorice (3:2:3), add 8 times the weight of water to decoct 3 times , extracted for 3 hours each time, filtered to obtain the extract, and concentrated to extract); the refined alkaloid group of Sini decoction prepared in Example 1 and Example 2 of the present invention (low concentration group 10mg / kg, medium concentration group 20mg / kg and high concentration 30mg / kg group); continuous oral administration for 7 days,...

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Abstract

The invention discloses sini decoction refined total alkaloid for preventing and treating heart diseases. According to the traditional Chinese medicine theories, by means of modern separation methods and pharmacological experiment tracking, the refined total alkaloid having high content of active components is prepared through extraction, enrichment, separation and purification by using a macroporous resin and ion exchange resin combination method and the like in a preferable process; the pharmacological experiment results show that the refined total alkaloid provided by the invention has the good cardiac muscle cell protection effect and is capable of preventing myocyte necrosis and well protecting hearts; in addition, the sini decoction refined total alkaloid disclosed by the invention is low in adverse effect and good in clinical medication safety.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine, in particular to refined total alkaloids of Sini Decoction which has the effect of preventing and treating heart disease and its application, belonging to the field of medicine and pharmacy. Background technique [0002] Sini Decoction originated from Zhang Zhongjing's "Treatise on Febrile Diseases". It is a representative prescription for returning to the yang and rescuing the adversity. It is composed of aconite, dried ginger, and roasted licorice. For nearly 2,000 years since the prescription was created, physicians of all dynasties have used the traditional decoction method for clinical use, and the curative effect is remarkable. Modern pharmacological studies have shown that it has the effects of anti-shock, anti-atherosclerosis, and increasing blood flow. The royal medicine aconite mainly contains alkaloids and polysaccharides, the ministerial medicine dried ginger contains a larg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P9/00
Inventor 孟永海陈忠新张文娓方芳张春燕翟春梅牟景龙李强
Owner 孟永海