Injectable bioactive artificial bone material and preparation method and application thereof

A bioactive, artificial bone technology used in the field of medicine to prevent body fluid erosion

Inactive Publication Date: 2014-04-23
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the injectable tissue engineering scaffold material is in a fluid state before injection, and it is easy to load seed cells and compound growth factors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Mix tetracalcium phosphate and calcium hydrogen phosphate at a molar ratio of 1:2, mix them by ball milling in an anhydrous ethanol medium, and dry them at 80°C to obtain a phosphate mixture;

[0026] (2) Mix the phosphate mixture prepared in step (1) and carbodiimide evenly at a mass ratio of 10:1 to obtain a solid phase;

[0027] (3) Mix chitosan, citric acid and water according to the mass ratio of 1:4:100, and fully stir to obtain a liquid phase;

[0028] (4) Blending the solid phase prepared in step (2) and the liquid phase prepared in step (3) at a solid-to-liquid ratio of 0.8 g: 1 ml to prepare an injectable bioactive artificial bone material.

Embodiment 2

[0030] (1) Mix tetracalcium phosphate and calcium hydrogen phosphate at a molar ratio of 1:2, mix them by ball milling in an anhydrous ethanol medium, and dry them at 80°C to obtain a phosphate mixture;

[0031] (2) Mix the phosphate mixture prepared in step (1) and carbodiimide evenly at a mass ratio of 10:1 to obtain a solid phase;

[0032] (3) Mix chitosan, citric acid and water according to the mass ratio of 2:5:100, and fully stir to obtain a liquid phase;

[0033] (4) Blending the solid phase prepared in step (2) and the liquid phase prepared in step (3) at a solid-to-liquid ratio of 1 g: 1 ml to prepare an injectable bioactive artificial bone material.

Embodiment 3

[0035] (1) Mix tetracalcium phosphate and calcium hydrogen phosphate at a molar ratio of 1:2, mix them by ball milling in an anhydrous ethanol medium, and dry them at 80°C to obtain a phosphate mixture;

[0036] (2) Mix the phosphate mixture prepared in step (1) and carbodiimide evenly at a mass ratio of 10:1 to obtain a solid phase;

[0037] (3) Mix chitosan, citric acid and water according to the mass ratio of 1:5:100, and fully stir to obtain a liquid phase;

[0038] (4) Blending the solid phase prepared in step (2) and the liquid phase prepared in step (3) at a solid-to-liquid ratio of 1.2g: 1ml to prepare an injectable bioactive artificial bone material.

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Abstract

The invention discloses an injectable bioactive artificial bone material and a preparation method and application thereof, belonging to the field of medicinal technology. The injectable bioactive artificial bone material is prepared by a solid phase and a liquid phase according to the solid-liquid ratio of (0.8-1.2)g:1ml, wherein the solid phase comprises a phosphate mixture and carbodiimide, the mass ratio of the phosphate mixture to a condensing agent is 10:1, and the phosphate mixture comprises tetracalcium phosphate and calcium hydrophosphate according to the molar ratio of 1:2; the liquid phase comprises water, chitosan and citric acid, and the mass ratio of water to chitosan to citric acid is 100:(1-2):(4-5). Covalent coupling of a bioactive molecule and a chitosan derivative is realized through the carbodiimide condensing agent. The injectable bioactive artificial bone material is widely used in preparation of artificial bones.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an injectable bioactive artificial bone material, its preparation method and application. Background technique [0002] Calcium phosphate bone cement is currently the most widely used injectable bone repair material, but as a tissue engineering scaffold, the biggest defect of calcium phosphate bone cement is that it has small pores, which is not conducive to cell growth, and its curing speed is slow. After curing, the granular calcium and phosphate salts are easy to lose and shift, and the strength after curing is low. Another self-curing bone cement, PMMA, has defects such as exothermic during curing, biological inertness, poor integration with autogenous bone, and harmful residual monomers to the human body. Its clinical use has been questioned. [0003] At present, the research and development of injectable bone tissue engineering scaffold materials are mostly fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/20A61L27/54A61L27/00
Inventor 李志忠孙国栋焦延鹏
Owner JINAN UNIVERSITY
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