Radiopaque polymer and preparation method and application thereof

A technology of polymers and compounds, applied in the field of radiopaque polymers and their preparation, can solve the problems of lack of clinical conditions for treatment, fragile precipitation, high mechanical properties, etc., achieve long-term developing effects, not easy to biodegrade, and moderate curing speed Effect

Active Publication Date: 2022-07-29
苏州美创医疗科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, Chinese patent CN101513542B obtains a class of I-PVA polymers by grafting iodobenzoyl chloride or iodobenzamide to poly(vinyl alcohol) (PVA) through ester bonds. Due to the presence of ester bonds in the structure, the polymer is biodegradable, has poor stability, and has only 35-45% iodine grafted onto the polymer
Chinese patent CN102781974A describes a class of iodobenzyl chloride grafted to poly(vinyl alcohol) via an ether bond to form an iodobenzyl ether-PVA polymer. This type of polymer has improved stability and is a non-biodegradable polymer. However, with the increase in the number of iodine substitutions and iodine content in benzyl iodide, the triiodobenzyl or polyiodobenzyl substituted polymers have higher mechanical properties, and the precipitates formed in biological solvents are fragile and brittle
[0005] Currently, biostable liquid embolization systems with good clinical handling properties are still lacking for the treatment of clinical conditions

Method used

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  • Radiopaque polymer and preparation method and application thereof
  • Radiopaque polymer and preparation method and application thereof
  • Radiopaque polymer and preparation method and application thereof

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preparation example Construction

[0040] The present invention designs a kind of opaque polymer, which is obtained by the following preparation method, and the method mainly comprises the following steps:

[0041] Step 1, dissolving polyvinyl alcohol in water, adding an alkaline catalyst and epichlorohydrin, and reacting at a temperature of 50-95° C. for 5-50 min to obtain activated polyvinyl alcohol;

[0042] Step 2: Dissolving the activated polyvinyl alcohol obtained in step 1 in a polar aprotic solvent, adding an alkali compound and an iodobenzyl alcohol compound, and reacting at a temperature of 90-200° C. for 1-12 hours to obtain a radiopaque polymer.

[0043] In the present invention, the polyvinyl alcohol is activated by grafting epichlorohydrin onto the polyvinyl alcohol under the condition of a basic catalyst, and then the iodobenzyl alcohol compound is grafted onto the activated polyvinyl alcohol through an etherification reaction to obtain a Transmissive polymer. Compared with other existing graft ...

Embodiment 1

[0086] (1) Preparation of activated polyvinyl alcohol

[0087]

[0088] Add 100g of purified water and 10g of polyvinyl alcohol with a weight average molecular weight of 13000 (-OH0.227mol) into the reaction flask, heat to 90°C to completely dissolve the polyvinyl alcohol, when the solution has no precipitation and a transparent color, it is completely dissolved;

[0089] Put 22g epichlorohydrin (0.238mol) and 0.5g catalyst NaOH into the reactor, react at 75°C, slowly drop the reaction solution into a beaker containing methanol precipitant, and stir with a glass rod while adding dropwise. , the precipitated white flocculent precipitate was repeatedly filtered and washed with methanol for three times, and then dried to constant weight at 50-60° C. to obtain activated polyvinyl alcohol (ECH-PVA).

[0090] (2) Preparation of opaque polymers

[0091]

[0092] Under nitrogen flow, the activated polyvinyl alcohol obtained in step (1) was dissolved in 100 ml of anhydrous NMP. T...

Embodiment 2

[0095] (1) Add 100g purified water and 10g polyvinyl alcohol (-OH 0.227mol) with a weight average molecular weight of 13000 to the reaction bottle, heat to 90°C to completely dissolve the polyvinyl alcohol, and dissolve when the solution has no precipitation and a transparent color. completely;

[0096] Put 11g epichlorohydrin (0.119mol) and 0.5g catalyst NaOH into the reactor, react at 75°C, slowly drop the reaction solution into a beaker containing methanol precipitant, and stir with a glass rod while adding dropwise. , the precipitated white flocculent precipitate was repeatedly filtered and washed with methanol for three times, and then dried to constant weight at 50-60° C. to obtain activated polyvinyl alcohol (ECH-PVA).

[0097] (2) Under nitrogen flow, the activated polyvinyl alcohol obtained in step (1) was dissolved in 100 ml of anhydrous NMP. The reaction mixture was stirred at 130°C for 5 minutes; the temperature was then lowered to 50°C. 55 g of 2,3,5-iodobenzyl ...

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Abstract

The invention discloses an opaque polymer as well as a preparation method and application thereof. The opaque polymer provided by the invention contains a polyvinyl alcohol main chain and a developing side group grafted to the polyvinyl alcohol main chain, and the developing side group is formed by grafting an iodobenzyl alcohol compound to activated polyvinyl alcohol through an etherification reaction; the activated polyvinyl alcohol refers to that epoxy chloropropane is grafted to polyvinyl alcohol under the condition of a basic catalyst, so that chlorine atoms are introduced to the polyvinyl alcohol; the chemical structural formula of the developing side group is-OCH2CH (OH) CH2OR, R is iodobenzyl, and the polymer is soluble in a non-physiological solution and insoluble under physiological conditions, can be used as a liquid embolism material in medical treatment, and has high stability and excellent developing effect.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a non-transmissive polymer and a preparation method and application thereof. Background technique [0002] Therapeutic embolization is a minimally invasive procedure in which a material is introduced into a blood vessel to create a blockage that slows or stops blood flow. It uses different types of catheters to reach the patient's blood vessels and inject the embolic material into the blood supply blood vessels or lesions in a controlled manner, so as to occlude and interrupt the blood supply, so as to control bleeding, treat vascular lesions, treat tumors and The purpose of eliminating diseased organs. Liquid embolic agents are materials that are delivered in liquid form and then gel, solidify, or precipitate in situ. For liquid embolic systems that rely on delivery in organic solvents, these organic solvents are rapidly dissipated in the blood, leaving the embolic mate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F8/18C08F116/06A61L24/00A61L24/06
CPCC08F8/18A61L24/001A61L24/06A61L2430/36C08F116/06C08L29/04
Inventor 刘文菁汪青松李慧
Owner 苏州美创医疗科技有限公司
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