Preparation method of amino-enriched polymeric thin film

Abstract

The invention discloses a preparation method of an amino-enriched polymeric thin film. A double-terminal amino compound and a catechol compound are copolymerized by Michael addition and Schiff alkali reaction, so as to form a film with abundant amino functional groups. Regulation and control on the density of the surface amino functional group can be achieved by regulating and controlling the conditions such as reaction time, reactant concentration, oxygen concentration, the temperature and the like. A target film surface not only contains abundant amino functional groups, is high in intermolecular crosslinking degree, and good in film stability, and provides abundant reaction sites for different types of biological material surface-grafted biological molecules, but also has good biocompatibility on vascular cells.

Description

technical field [0001] The invention relates to the surface modification of medical biomaterials, in particular to the technical field of a method for preparing polymeric films with abundant amine functional groups. Background technique [0002] Surface modification of biomaterials is a technology that improves the surface properties of materials or enhances special surface properties without affecting the properties of the material itself. It plays an irreplaceable role in the fields of chemistry, biology, materials science, and applied science, engineering, and technology. effect. Existing methods for functional modification of material surfaces include self-assembled thin films, silanization, physical / chemical vapor deposition, and surface grafting. Although these methods are commonly used in research, many methods have many limitations in wide application. For example, the requirements for interface modification and chemical specificity between surfaces, complex equipme...

AI Technical Summary

Problems solved by technology

However, the secondary reactivity of the dopamine film is limited to biomolecules with sulfhydryl or amine groups, because the secondary reactivity of the dopamine film is based on the combination of the phenolic hydroxyl or quinone groups retained on the dopamine film with the biomolecules. Amino or sulfhydryl based on Michael addition or Schiff base reaction

However, there is no report on the introduction of hexamethylenediamine and dopamine copolymerization to prepare films.