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Preparation method of amino-enriched polymeric thin film
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A technology rich in amine groups and thin films, which is applied in the field of surface modification of medical biomaterials to achieve the effects of low process cost, good physical and chemical stability, and good stability
Inactive Publication Date: 2014-04-23
SOUTHWEST JIAOTONG UNIV
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Problems solved by technology
However, the secondary reactivity of the dopamine film is limited to biomolecules with sulfhydryl or amine groups, because the secondary reactivity of the dopamine film is based on the combination of the phenolic hydroxyl or quinone groups retained on the dopamine film with the biomolecules. Amino or sulfhydryl based on Michael addition or Schiff base reaction
However, there is no report on the introduction of hexamethylenediamine and dopamine copolymerization to prepare films.
Method used
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Embodiment 1
[0023] A preparation method of a rich amine-based polymeric film, the steps of which are:
[0024] A. Material preparation.
[0025] The 316L stainless steel that needs to be modified as the base material is polished, cleaned, and dried for use;
[0026] B. Film preparation.
[0027] Dissolve 1mg / ml dopamine and 20mg / ml hexamethylenediamine in alkaline Tris-base buffer, soak the base material prepared in A in the solution after the reactants are uniformly mixed and react for 48h, then fully rinse with distilled water, dry, That is, a film rich in amine groups on the surface is obtained.
Embodiment 2
[0029] A preparation method of a rich amine-based polymeric film, the steps of which are:
[0030] A. Material preparation.
[0031] Clean and dry polytetrafluoroethylene, the base material that needs to be modified, for use;
[0032] B. Film preparation.
[0033] Dissolve 2mg / ml dopamine and 15mg / ml ethylenediamine in alkaline Tris-base buffer (, soak the base material prepared in A in the solution after the reactants are uniformly mixed and react for 24h, then fully rinse with distilled water, and dry , that is, a film rich in amine groups on the surface is obtained.
Embodiment 3
[0035] A preparation method of a rich amine-based polymeric film, the steps of which are:
[0036] A. Material preparation.
[0037] Polish, clean, and dry the iron-based alloy that needs to be modified as the base material for use;
[0038] B. Film preparation.
[0039] Dissolve 1mg / ml dopamine and 20mg / ml polylysine (PLL) in alkaline Tris-base buffer, soak the base material prepared in A in the solution after the reactants are uniformly mixed and react for 12h, then wash with distilled water Fully rinse and dry to obtain a film rich in amine groups on the surface.
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Abstract
The invention discloses a preparation method of an amino-enriched polymeric thin film. A double-terminal amino compound and a catechol compound are copolymerized by Michael addition and Schiff alkali reaction, so as to form a film with abundant amino functional groups. Regulation and control on the density of the surface amino functional group can be achieved by regulating and controlling the conditions such as reaction time, reactant concentration, oxygen concentration, the temperature and the like. A target film surface not only contains abundant amino functional groups, is high in intermolecular crosslinking degree, and good in film stability, and provides abundant reaction sites for different types of biological material surface-grafted biological molecules, but also has good biocompatibility on vascular cells.
Description
technical field [0001] The invention relates to the surface modification of medical biomaterials, in particular to the technical field of a method for preparing polymeric films with abundant amine functional groups. Background technique [0002] Surface modification of biomaterials is a technology that improves the surface properties of materials or enhances special surface properties without affecting the properties of the material itself. It plays an irreplaceable role in the fields of chemistry, biology, materials science, and applied science, engineering, and technology. effect. Existing methods for functional modification of material surfaces include self-assembled thin films, silanization, physical / chemical vapor deposition, and surface grafting. Although these methods are commonly used in research, many methods have many limitations in wide application. For example, the requirements for interface modification and chemical specificity between surfaces, complex equipme...
Claims
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Application Information
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