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Sodium management for dialysis systems

A technology of dialysate and sodium ions, applied in the field of dialysis therapy, can solve the problems of high cost of adsorbent, change of sodium level, difficulty in verifying purity, etc.

Active Publication Date: 2014-04-23
BAXTER INT INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main drawbacks of sorbent systems are the high cost of the sorbent; the amount of space required to house the sorbent; and concerns about the purity of the recirculating solution, since many ions remain in the fluid after treatment and are technically difficult to verify purity
Specifically, sodium levels in sorbent-treated dialysis solutions may become a problem

Method used

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  • Sodium management for dialysis systems
  • Sodium management for dialysis systems
  • Sodium management for dialysis systems

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0088] Example 1: ZrP ion exchange column in acidic form

[0089] The ion exchange column in acidic form was prepared by filling an empty chromatographic column (GE C10 / 10 column: 19-5001 -01), and wash with 500mL0.1M hydrochloric acid solution at 5mL / min to ensure that the cation exchange column is in acidic form. The column was flushed with 500 mL of deionized ("DI") water at 5 mL / min to ensure that residual hydrochloric acid in the column was removed prior to the experiment.

[0090] The exemplary solution was used in the experiment and the flow rate was measured at 5.88 mL / min. Samples were collected at the outlet of the column every five minutes, and time zero was defined when the exemplary solution completely replaced the DI water initially in the column. All samples were analyzed by clinical chemistry methods to measure ion concentrations. result( Figure 5 ) shows that at elution volumes between 104 and 310 mL, the sodium concentration reaches a plateau at about ...

example 2

[0091] Example 2: ZrP ion exchange column in sodium form

[0092] A column in the sodium form was prepared in a similar manner by successively filling an empty column with 3.622 g of zirconium phosphate resin and 1.984 g of activated carbon (CR2050C-AW, lot number CA10-2 from Carbon Resources) and filling it with 500 mL of saturated sodium bicarbonate solution was flushed at 5 mL / min to ensure that the cation exchange column was in the sodium form. The column was flushed with 500 mL DI water at 5 mL / min to ensure that residual sodium bicarbonate in the column was removed prior to the experiment.

[0093]The exemplary solution was used in the experiment and the flow rate was measured to be 4.3 mL / min. Samples were collected at the outlet of the column every five minutes, and time zero was defined when the exemplary solution completely replaced the DI water initially in the column. All samples were analyzed by clinical chemistry methods to measure ion concentrations. result...

example 3

[0094] Example 3: Combined ZrP column in acidic and sodium form

[0095] Based on the results from the two separate columns, a volumetric flow rate ratio modification of 3:1 was made to balance the output sodium levels through the combined parallel columns. The same column was used in this experiment. The flow rate through this column in the acid form was measured to be 1.61 mL / min and the flow rate through the column in the sodium form was measured to be 4.85 mL / min. The flows from the two columns are combined into one flow through a Y-connector with mixing capability. Samples were collected every four minutes and time zero was defined when the exemplary solution completely replaced the DI water initially in the column. All cations and anions were analyzed by clinical chemistry methods and pH was measured. Figure 7 Representative of typical results showing that the sodium concentration remains relatively constant at about 140 mM at elution volumes between 101 and 230 mL...

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Abstract

Systems and methods for providing dialysis therapies are provided. In a general embodiment, the present disclosure provides an apparatus for dialysis treatment, comprising first and second fluid flow pathways in a parallel arrangement. The first fluid flow pathway contains a first cation exchange resin, wherein greater than 90% of exchange sites of the first cation exchange resin are populated with hydrogen ions. The second fluid flow pathway contains a second cation exchange resin, wherein greater than 90% of exchange sites of the second cation exchange resin are populated with sodium ions. The apparatus can be used to maintain a constant and safe level of sodium in a constantly regenerated dialysis fluid over an extended period of time.

Description

technical field [0001] The present invention relates generally to dialysis therapy. More specifically, the present invention relates to sodium management in dialysis systems such as wearable kidneys. Background technique [0002] Hemodialysis and peritoneal dialysis are two types of dialysis therapy commonly used to treat loss of kidney function. Hemodialysis treatment filters a patient's blood to remove waste products, toxins, and excess water from the patient. A patient is connected to a hemodialysis machine and the patient's blood is pumped through the machine. Catheters are inserted into the patient's veins and arteries so that blood can flow to and from the hemodialysis machine. The blood passes through the machine's dialyzer, which removes waste products, toxins, and excess water from the blood, into a fluid called dialysate, which also passes through the dialyzer. The purified blood is returned to the patient. A large amount of dialysate (eg, about 120 liters) is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/16
CPCA61M1/1696A61M1/284
Inventor 元邦·塞缪尔·丁林荣升罗英成
Owner BAXTER INT INC
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