Physalin B crystal and extraction and preparation methods as well as application of physalin B crystal in preparing anti-inflammatory medicines

A technology of Physalis bitterin and extraction method, which is applied in the direction of drug combination, antipyretics, anti-inflammatory agents, etc., can solve the problems of muscle atrophy, unclear pathogenesis of inflammation, slow wound healing, etc., and achieve high anti-inflammatory effect.

Active Publication Date: 2014-04-30
GUANGDONG FOOD & DRUG VOCATIONAL COLLEGE
View PDF3 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

④ Long-term application can cause high blood pressure and atherosclerosis; ⑤ Cause osteoporosis, muscle atrophy, and slow wound healing
⑥ long-term use of such drugs will lead to d

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Physalin B crystal and extraction and preparation methods as well as application of physalin B crystal in preparing anti-inflammatory medicines
  • Physalin B crystal and extraction and preparation methods as well as application of physalin B crystal in preparing anti-inflammatory medicines
  • Physalin B crystal and extraction and preparation methods as well as application of physalin B crystal in preparing anti-inflammatory medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Extraction and preparation of Physalisin B crystals

[0042] 1. Extraction

[0043] First, remove 8kg of bitter gourds, weeds, mud and other sundries, chop the stems of the plants, and the leaves and fruits have been dried and can be crushed with a slight tap. Soak the crushed plant materials in medical alcohol with a concentration of 85vol%. Extraction, the alcohol liquid surface is not over the plant material, to prevent the air from contacting with the plant material, leave it for a week, the extract is a dark green solution, pour out the extract. Carry out the second extraction as above, and the third extraction.

[0044] Combine the extracts, recover alcohol under reduced pressure with a rotary evaporator, concentrate to a small volume, pour the concentrate into an evaporating dish, place the evaporating dish on a water bath, and concentrate to dryness to obtain the extract extract.

[0045] 2. Refined

[0046] Grind the extract (1067g), and the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Crystal densityaaaaaaaaaa
Login to view more

Abstract

The invention discloses a physalin B crystal which belongs to a monoclinic system, wherein the space group is P2(1); the lattice parameters (i)a(/i) is equal to 12.4996 (2), (i)b(/i) is equal to 14.35620(10), (i)c(/i) is equal to 14.75190(10) and (i)beta(/i) is equal to 99.8740(10) degrees; the volume of the crystal cell is 2607.97(5)3; the crystalline density is 1.382mg/m<3>; (i)Z(/i) is equal to 4; F(000) is equal to 1152; the final departure factors (i)R1(/i) is equal to 0.0407, and (i)wR2(/i) is equal to 0.1056. The invention further discloses an extraction method of the crystal. The extraction method comprises the following steps: 1) extracting a physalis plant material to remove a solvent to obtain an extract; 2) repeatedly dissolving soluble parts of the extract by petroleum ether, standing and filtering; 3) repeatedly dissolving the extract treated by petroleum ether by ethyl acetate, standing, filtering, combining the filtrate and removing the solvent to obtain a solid; and 4) dissolving the solid, mixing a sample by silica gel, passing through a column by a dry method, carrying out gradient elution, collecting an eluant, repeatedly carrying out column chromatography, and finally, removing the solvent from the eluant. The invention further discloses an application of the physalin B crystal in preparing anti-inflammatory medicines. The crystal obtained by the invention has higher anti-inflammatory activity.

Description

technical field [0001] The invention relates to a physalis B crystal, an extraction and preparation method thereof and an application of the physalis B crystal in the preparation of anti-inflammatory drugs. Background technique [0002] Inflammatory response is one of the important defense mechanisms of the body against tissue cell damage caused by physical, chemical, immune or biological factors. It is also the basic pathological process of the occurrence and development of many diseases. Diseases (such as rheumatoid arthritis, rheumatic fever, osteoarthritis), asthma, chronic obstructive pulmonary disease, trauma, burns, endotoxic shock, Alzheimer's disease, and even heart failure all have inflammatory mediators participate. [0003] Anti-inflammatory drugs are divided into two categories: steroids (adrenocortical hormones) and non-steroidal anti-inflammatory drugs (NSAIDs). Can be divided into ① mineralocorticoids. ② glucocorticoids, etc. Glucocorticoids have extensiv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D493/22A61K31/366A61P29/00
CPCC07D493/22
Inventor 杨燕军曾庆钱沙聪威黄勇红何盛江张晓明
Owner GUANGDONG FOOD & DRUG VOCATIONAL COLLEGE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap