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Nanoparticles, and preparation method, application and preparation thereof

A nanoparticle and organic solvent technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as difficulty in administration, impact on application and research, and low bioavailability , to improve the solubility and biocompatibility, and improve the relative bioavailability in vivo

Inactive Publication Date: 2014-05-14
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the poor water solubility of α-hedera saponin, it can only be administered by intragastric administration in animal experiments, resulting in low bioavailability, and difficulty in intraperitoneal and intravenous administration, which affects its further application and research.

Method used

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  • Nanoparticles, and preparation method, application and preparation thereof
  • Nanoparticles, and preparation method, application and preparation thereof
  • Nanoparticles, and preparation method, application and preparation thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0056] The preparation of embodiment 1 nanoparticle

[0057] Accurately weigh 80mg F68 and 50mg GC, dissolve in 20mL of 0.2% acetic acid aqueous solution as the water phase; accurately weigh 20mgα-Hed and 80mg phospholipids, dissolve in 4mL ethanol / acetone (1:1) mixed solvent as the organic phase, in Under the condition of magnetic stirring at 30°C, quickly inject the organic phase into the water phase, keep stirring for 5 minutes, then dilute to 70mL with distilled water, and cut it with a high-speed shearer at 20000rpm for 5min, and then homogenize it with a high-pressure homogenizer at 1000bar. After massaging for 5 minutes, it was filtered through a 0.45 μm microporous membrane to obtain a colloidal solution of nanoparticles, that is, α-hedera-N-lactosylchitosan nanoparticles (α-Hed-GC-NP) were obtained.

Embodiment 2

[0058] The preparation of embodiment 2 nanoparticles

[0059] Accurately weigh 80mg of F68 and 50mg of GC, dissolve in 20mL of 0.2% acetic acid aqueous solution as the water phase; accurately weigh 20mg of α-Hed and 80mg of phospholipids and dissolve in 4mL of ethanol as the organic phase. Inject the phase into the water phase quickly, keep stirring for 10min, then dilute to 70mL with distilled water, and cut it with a high-speed shearer at 20000rpm for 5min, then homogenize it at 1000bar for 5min with a high-pressure homogenizer, and pass through a 0.45μm microporous filter The nanoparticle colloidal solution was obtained by membrane filtration, that is, the α-hederin-N-lactosylchitosan nanoparticle (α-Hed-GC-NP) was obtained. The preparation of embodiment 3 nanoparticles

Embodiment 3

[0059] Accurately weigh 80mg of F68 and 50mg of GC, dissolve in 20mL of 0.2% acetic acid aqueous solution as the water phase; accurately weigh 20mg of α-Hed and 80mg of phospholipids and dissolve in 4mL of ethanol as the organic phase. Inject the phase into the water phase quickly, keep stirring for 10min, then dilute to 70mL with distilled water, and cut it with a high-speed shearer at 20000rpm for 5min, then homogenize it at 1000bar for 5min with a high-pressure homogenizer, and pass through a 0.45μm microporous filter The nanoparticle colloidal solution was obtained by membrane filtration, that is, the α-hederin-N-lactosylchitosan nanoparticle (α-Hed-GC-NP) was obtained. The preparation of embodiment 3 nanoparticles

[0060] Accurately weigh 80mg of F68 and 50mg of GC, dissolve in 20mL of 0.2% acetic acid aqueous solution as the aqueous phase; accurately weigh 20mg of α-Hed and 80mg of phospholipids and dissolve in 1mL of acetone as the organic phase. Inject the phase into...

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Abstract

The invention relates to the pharmaceutic preparation field and in particular relates to nanoparticles, and a preparation method, an application and a preparation thereof. The nanoparticles comprise alpha-Hed (alpha-Hederin), GC (Glucose Corticosteroid) and phospholipid. The nanoparticles are round in appearance, even in distribution and also even in particle size distribution, the drug (alpha-Hed) is evenly dispersed in a carrier material and the release of the drug has certain pH sensitivity and controlled-release characteristic, and therefore, the active targeting effect can be developed and the in vivo bioavailability of the drug can be improved; and consequently, the nanoparticles have a good anti-liver tumor effect.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a nanoparticle and its preparation method, application and preparation. Background technique [0002] Liver cancer refers to malignant tumors that occur in the liver, and its mortality rate ranks third among malignant tumors. According to the statistics of the World Health Organization, the incidence of primary liver cancer is on the rise all over the world, and nearly 50% of the new cases appear in China. Therefore, how to prevent and treat liver cancer has become a hot spot in modern medical research. [0003] In recent years, the research on the anti-tumor active components of traditional Chinese medicine has achieved fruitful results, and a variety of chemical components with anti-tumor effects have been successfully isolated from traditional Chinese medicine. α-hedera saponin (α-Hed) is the active ingredient extracted from the traditional Chinese medicine Pulsati...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/704A61K47/36A61K47/24A61P1/16A61P35/00
Inventor 杨世林游本刚冯育林许琼明刘艳丽李笑然
Owner JIANGXI HERBFINE HI TECH
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