Glutathione sensor, preparation method thereof and application thereof in capillary electrophoresis amperometric detection

A glutathione and sensor technology, applied in the field of sensors, can solve the problems of high detection limit and low sensitivity, and achieve the effects of fast response speed, high sensitivity and wide linear range
CN103808787AInactive Publication Date: 2014-05-21SHANDONG NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG NORMAL UNIV
Publication Date
2014-05-21
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to a glutathione sensor, a preparation method thereof and application thereof in capillary electrophoresis amperometric detection. The preparation method comprises the following steps: polishing the cross section of a carbon fiber micro-disk electrode to be smooth, carrying out ultrasonic cleaning on the polished carbon fiber micro-disk electrode, and immersing the cleaned cross section of the carbon fiber micro-disk electrode into a 0.3gm / mL-0.7mg / mL of graphene oxide solution for 10-20s, and then drying in the air; reducing the graphene oxide on the carbon fiber micro-disk electrode, wherein the electro-deposition potential is at constant potential of -1.2 to -0.7V, the electricity reduction time is 150-370s, and the obtained electrode is the glutathione sensor. The sensor electrode is wide in linear range, high in sensitivity and fast in response speed, electroactive materials possible in actual samples such as dopamine, epinephrine, cysteine and the like have no interference to the determination of the glutathione.
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Description

technical field

[0001] The present invention relates to a sensor, especially a glutathione sensor, its preparation method and its application in the determination of glutathione content in glutathione eye drops by capillary electrophoresis amperometry, which belongs to electroanalytical chemical detection technology field. Background technique

[0002] Chemically modified electrodes are various modifications on conductors or semiconductor electrodes, so as to endow the electrodes with certain special properties, which can have more sensitive response signals to certain substances, and overcome the overpotential that unmodified electrodes tend to appear in the measurement It has been widely used in the field of analytical chemistry, especially in the preparation of biosensors.

[0003] Commonly used chemically modified electrodes include chemically modified carbon paste microelectrodes, metal and nonmetal nanoparticle modified microelectrodes, surface molecular film modified...

Claims

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