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A kind of Zizhi polysaccharide tablet and preparation method thereof

A polysaccharide and tablet technology, applied in the field of medicine, can solve the problems of slow disintegration rate of Zizhi polysaccharide tablets, unable to meet the needs of treatment, moisture absorption, etc., and achieve the effects of good long-term storage stability, definite therapeutic effect, and long application history.

Active Publication Date: 2014-10-08
江西泽众制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The applicant found that since Zizhi polysaccharide is easily soluble in water, hygroscopic and sticky phenomena will occur in the process of preparing Zizhi polysaccharide tablets; at the same time, when the auxiliary materials and their dosages are not selected properly, the disintegration speed of Zizhi polysaccharide tablets is relatively slow, Unable to meet clinical treatment needs

Method used

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  • A kind of Zizhi polysaccharide tablet and preparation method thereof
  • A kind of Zizhi polysaccharide tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of Zizhi polysaccharide powder:

[0032] Wash the Zizhi fruiting body and / or mycelium, drain, add water and decoct twice, decoct for 2 hours for the first time, filter the medicinal liquid with a 100-mesh filter cloth, add 5 times the amount of water to the dregs for the second The second decoction for 2 hours, the medicinal liquid was filtered with a 100-mesh filter cloth, the medicinal liquid obtained by the second decoction was combined, and concentrated under reduced pressure to a clear paste with a relative density of 1.15 (heat measurement at 50°C), and stirred into the clear paste to add 95% Ethanol until the alcohol content reaches 62%, let it stand for 24 hours, take the supernatant to recover the ethanol until there is no alcohol smell, and the precipitate after recovering the ethanol is vacuum-dried at 60°C, and the moisture content of the dry extract is controlled within 3%. Put the paste into a high-efficiency pulverizer and pulverize it into fi...

Embodiment 2

[0034] prescription:

[0035] .

[0036] Preparation:

[0037] Weigh Zizhi polysaccharide powder, starch and dextrin according to the prescription, and mix them evenly; use 30% ethanol solution to make a soft material from the mixture, and pass through a 16-mesh sieve to granulate; dry the wet granules at 60°C, so that the moisture content of the granules is 3.0%; Pass the dried granules through a 14-mesh sieve for granulation; add magnesium stearate to the granulated granules, mix well, and press into tablets.

Embodiment 3

[0039] prescription:

[0040] .

[0041] Preparation:

[0042] Weigh Zizhi polysaccharide powder, starch, dextrin and sucrose according to the prescription, and mix them evenly; use 40% ethanol solution to make a soft material from the mixture, and pass through a 18-mesh sieve to granulate; dry the wet granules at 70°C, so that the water content of the granules is 3.2 %; pass the dried granules through a 16-mesh sieve for granulation; add magnesium stearate to the granules of the granules, mix well, and press into tablets.

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Abstract

The invention provides a Zizhi polysaccharide tablet and a preparation method thereof. The Zizhi polysaccharide tablet comprises 200-300 parts by weight of Zizhi polysaccharide powder, 30-60 parts by weight of dextrin, 30-60 parts by weight of starch and 0.5-2.0 parts by weight of magnesium stearate. The present invention uses cheap dextrin, starch, etc. as the main auxiliary materials of the tablet, which realizes good tablet performance, such as better disintegration speed, small difference in tablet weight, controllable dosage, and good long-term storage stability, etc. And solve the technical problem of sticking and punching. The prepared Zizhi polysaccharide tablet can be used to treat neurasthenia, leukopenia and thrombocytopenia, ionizing radiation and occupational hematopoietic injury, and leukopenia in tumor patients after radiotherapy and chemotherapy, and has no stimulation to the human body and few adverse reactions.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a tablet of Zizhi polysaccharide and a preparation method thereof. Background technique [0002] Leukopenia refers to the absolute count of peripheral blood white blood cells continuously lower than 4.0×10 9 / L. Neutrophils are the main component of white blood cells, so neutropenia often leads to leukopenia. The disease can be divided into mild, moderate and severe leukopenia according to the degree of neutropenia. Generally, patients with mild reduction do not have special symptoms clinically, and mostly manifest as symptoms of the primary disease. Moderate and severe decreasers are prone to infection and non-specific symptoms such as fatigue, weakness, dizziness, and loss of appetite. Platelet disorders are caused by poor hemostatic clot formation and bleeding due to decreased number (thrombocytopenia) or decreased function (thrombocytopenia) of platelets. The platelet count is be...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/715A61K47/36A61P25/20A61P7/00A61P1/14
Inventor 于新江
Owner 江西泽众制药股份有限公司
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