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Medicine composition consisting of methylprednisolone aceponate and zinc oxide

A kind of technology of methylprednisolone acetonide and composition, applied in the pharmaceutical composition that zinc oxide is an active ingredient, in the field of methylprednisolone acetonide, the problems such as the change of preparation pH value can be solved

Inactive Publication Date: 2014-06-25
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] When zinc oxide and methylprednisolone acetate are made into a compound drug, zinc oxide will cause a significant change in the pH value of the preparation, thereby promoting the decomposition of methylprednisolone acetate and causing problems in product stability

Method used

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  • Medicine composition consisting of methylprednisolone aceponate and zinc oxide
  • Medicine composition consisting of methylprednisolone aceponate and zinc oxide
  • Medicine composition consisting of methylprednisolone aceponate and zinc oxide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Active Ingredients: Methylprednisolone Acetate 1g, Zinc Oxide 10g

[0023] Oil phase ingredients: white petrolatum 50g, stearyl alcohol 30g, liquid paraffin 30g, surfactant 1

[0024] Water phase ingredients: surfactant 2, glycerin 50g, propylene glycol 20g, ethylparaben 1g, citric acid (C 6 h 8 o 7 ·H 2 O) 10g, sodium citrate (Na 3 C 6 h 5 o 7 2H 2 O) Add 18g water for injection to 1000g

[0025] Accurately weighed according to the above ratio, the cream preparation process is as follows:

[0026] (1) Oil phase preparation: mix zinc oxide and oil phase ingredients heated to melt in a container, and keep the temperature at 90°C;

[0027] (2) Water phase preparation: Dissolve surfactant 2, citric acid, sodium citrate, and ethylparaben in water for injection, evenly disperse methylprednisolone acetate in glycerin and propylene glycol, mix the two, and heat , Stir evenly and keep the temperature at 90°C;

[0028] (3) Combine the phases: slowly add the oil phase...

Embodiment 2

[0040] Active Ingredients: Methylprednisolone Acetate 1g, Zinc Oxide 5g

[0041] Oil phase ingredients: white petrolatum 50g, stearyl alcohol 30g, liquid paraffin 30g, Pingpingjia A-20 35g, sodium lauryl sulfate 5g

[0042] Water phase ingredients: Pingpingjia A-20 10g, glycerin 50g, propylene glycol 20g, ethylparaben 1g, citric acid (C 6 h 8 o 7 ·H 2 O) 10g, sodium citrate (Na 3 C 6 h 5 o 7 2H 2 O) Add 18g water for injection to 1000g

Embodiment 3

[0044] Active Ingredients: Methylprednisolone Acetate 0.1g, Zinc Oxide 5g

[0045] Oil phase ingredients: 30g white petrolatum, 100g stearyl alcohol, 30g liquid paraffin, 25g Pingpingjia A-20, 5g sodium lauryl sulfate

[0046] Water phase ingredients: Pingpingjia A-20 20g, glycerin 50g, propylene glycol 50g, methylparaben 1g, citric acid (C 6 h 8 o 7 ·H 2 O) Add 7g water for injection to 1000g

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PUM

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Abstract

The invention relates to a steride cortical hormone medicine composition, and in particular relates to a medicine composition taking methylprednisolone aceponate and zinc oxide as active ingredients.

Description

technical field [0001] The invention relates to a steroid corticosteroid pharmaceutical composition, in particular to a pharmaceutical composition with methylprednisolone acetate and zinc oxide as active ingredients. Background technique [0002] Methylprednisolone aceponate (Methylprednisolone aceponate, CAS: 86401-95-8) is a kind of steroid corticosteroid, as a fourth-generation glucocorticoid, it has a good effect when used locally, and only needs to be administered once a day It can achieve the same therapeutic effect as the potent glucocorticoid betamethasone valerate administered twice a day, with less systemic absorption and strong tolerance, which overcomes the shortcoming that general external glucocorticoids cannot be administered on a large area of ​​the body. Compared with prednisolone, the introduction of the methyl group at the C6 position and the introduction of the two ester groups at the C17 and C21 positions greatly increase the lipophilicity of methylpredn...

Claims

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Application Information

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IPC IPC(8): A61K33/30A61K9/06A61K47/20A61K47/34A61P17/00A61K31/573
Inventor 曲志萍王宇
Owner TIANJIN JINYAO GRP
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