Coaxial electrostatic spinning fibrous scaffold and preparation method thereof

A technology of coaxial electrospinning and fiber support, which is applied in fiber processing, rayon manufacturing, fiber chemical characteristics, etc., to achieve the effects of simple method, prolonged release and absorption time, and easy control.

Active Publication Date: 2014-07-02
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem of limitations in the application of coaxial electrospun fiber scaffolds in the prior art, an embodiment of the present invention provides a coaxial electrospun fiber scaffold

Method used

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  • Coaxial electrostatic spinning fibrous scaffold and preparation method thereof
  • Coaxial electrostatic spinning fibrous scaffold and preparation method thereof
  • Coaxial electrostatic spinning fibrous scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] An embodiment of the present invention provides a coaxial electrospun fiber scaffold 5 , which includes: an aliphatic polyester shell layer 51 and a polyvinylpyrrolidone core layer 52 .

[0046] The embodiment of the present invention provides a coaxial electrospun fiber scaffold 5 comprising an aliphatic polyester shell layer 51 and a polyvinylpyrrolidone core layer 52 . Since polyvinylpyrrolidone is a safe and non-toxic water-soluble pharmaceutical intermediate and pharmaceutical adjuvant, it can be miscible or compounded with various substances, making the coaxial electrospun fiber scaffold 5 safe and non-toxic and has excellent biocompatibility ; Because the N-H or O-H bond of polyvinylpyrrolidone can form intermolecular associations with various drugs and / or bioactive factors, and control the release time and action intensity of drugs and / or bioactive factors through the association, Prolonging the release and absorption time of the drug and / or bioactive factor in ...

Embodiment 2

[0048] The present invention provides a coaxial electrospinning fiber scaffold 5, the coaxial electrospinning fiber scaffold 5 includes: an aliphatic polyester shell layer 51 and a polyvinylpyrrolidone core layer 52 loaded with drugs and / or bioactive factors .

[0049] By adding drugs and / or bioactive factors to the polyvinylpyrrolidone core layer 52, the prepared coaxial electrospun fiber scaffold 5 has a medicinal function, and can be used for directional treatment of patients.

[0050] Specifically, the aliphatic polyester is at least one selected from polycaprolactone, polylactic acid, polylactic acid-glycolic acid copolymer, and poly(lactic acid-hexanol) copolymer, preferably polycaprolactone.

[0051] Based on the requirements for the biodegradability, mechanical properties and processability of the shell, the shell material of the fiber scaffold in the embodiment of the present invention is selected from polycaprolactone, polylactic acid, polylactic acid-glycolic acid cop...

Embodiment 3

[0058] as attached figure 1 As shown, the embodiment of the present invention provides a method for preparing a coaxial electrospun fiber scaffold, including:

[0059] Step 101: preparing an aliphatic polyester shell solution: dissolving the aliphatic polyester in an organic solvent and stirring until completely dissolved to obtain an aliphatic polyester shell solution.

[0060] Step 102: preparing a polyvinylpyrrolidone core layer solution: dissolving the polyvinylpyrrolidone in an organic solvent and stirring until completely dissolved to obtain a polyvinylpyrrolidone core layer solution.

[0061] Step 103: In a windless environment, inject the aliphatic polyester shell solution and the polyvinylpyrrolidone core solution into the shell solution injector 1 and the core solution injector 2 respectively, and perform coaxial electrospinning to prepare a coaxial Electrospun fiber scaffolds5.

[0062] The preparation method of the coaxial electrospinning fiber scaffold 5 provide...

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Abstract

The invention discloses a coaxial electrostatic spinning fibrous scaffold and a preparation method thereof, belonging to the field of biological tissue engineering. The scaffold comprises an aliphatic polyester shell and a polyvinylpyrrolidone core, not only is safe and non-toxic and has excellent biocompatibility but also has the functions of loading and slowly releasing drugs and / or bioactive factors, and can be widely applied to the field of biological tissue engineering. The invention also provides the preparation method of the coaxial electrostatic spinning fibrous scaffold. The preparation method comprises the step of carrying out coaxial electrostatic spinning by using an aliphatic polyester shell solution and a polyvinylpyrrolidone core solution in the windless environment to prepare a nanoscale electrostatic spinning fibrous scaffold. The nanoscale electrostatic spinning fibrous scaffold is safe and non-toxic, has a relatively high specific surface area and porosity, and has a good slow release function as a carrier of the drugs and / or bioactive factors. The method is simple, is easy to control, and has relatively strong practicability.

Description

technical field [0001] The invention relates to the field of biological tissue engineering, in particular to a coaxial electrospinning fiber support and a preparation method thereof. Background technique [0002] Fibrous scaffold is a biological tissue engineering scaffold. Because it has a nanoscale structure similar to natural extracellular matrix, it can mimic the structural characteristics of extracellular matrix. It can support cell growth, guide tissue regeneration, control tissue structure and release biologically active factors. And so on. Since the material and structure of the fibrous scaffold are the main factors affecting its function, the preparation of the fibrous scaffold is very important. Nanoscale fibers prepared by coaxial electrospinning technology not only have high specific surface area and porosity, but also have a structure similar to extracellular matrix. Therefore, coaxial electrospinning technology is commonly used to prepare "shell-core" fibers. ...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/18A61L27/54A61L27/22D01F8/14D01F8/10D01F1/10D01D5/34
Inventor 敖英芳满振涛邵振兴陈海峰尹玲
Owner PEKING UNIV THIRD HOSPITAL
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