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Enteric-coated soft capsule of Omega-3 aliphatic acid and its derivative and preparation method of the enteric-coated soft capsule

A technology of enteric-coated soft capsules and enteric-coated capsules is applied in the directions of capsule delivery, drug combination, cardiovascular system diseases, etc., which can solve the problems of high cost and complicated preparation process, and achieve convenient operation, simple preparation process and complete appearance. Effect

Inactive Publication Date: 2014-07-09
LP PHARM (XIAMEN) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on the fact that oral administration of omega-3 fatty acids and their derivatives can cause gastric discomfort, and the preparation process of existing omega-3 fatty acid enteric-coated preparations is complicated and costly, the present invention provides a new and convenient omega-3 fatty acid and its derivatives Enteric-coated soft capsule and preparation method thereof

Method used

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  • Enteric-coated soft capsule of Omega-3 aliphatic acid and its derivative and preparation method of the enteric-coated soft capsule
  • Enteric-coated soft capsule of Omega-3 aliphatic acid and its derivative and preparation method of the enteric-coated soft capsule
  • Enteric-coated soft capsule of Omega-3 aliphatic acid and its derivative and preparation method of the enteric-coated soft capsule

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Effect test

Embodiment 1

[0030] The preparation of embodiment 1Omega-3 fatty acid soft capsule

[0031]

[0032] Soft capsule preparation: mix the above-mentioned raw materials and corresponding auxiliary materials as the content of the soft capsule, put them in a soft capsule forming machine, select an appropriate mold, wrap and press with gelatin film to form a soft capsule.

Embodiment 2

[0033] The preparation of embodiment 2Omega-3 fatty acid ethyl ester soft capsule

[0034]

[0035]

[0036] Soft capsule preparation: mix the above-mentioned raw materials and corresponding auxiliary materials as the content of the soft capsule, put them in a soft capsule forming machine, select an appropriate mold, wrap and press with gelatin film to form a soft capsule.

Embodiment 3

[0037] The preparation of embodiment 3 Omega-3 fatty acid enteric-coated soft capsules

[0038] Enteric coating solution prescription: Kollicoat MAE30DP methacrylic acid / ethyl acrylate (1:1) copolymer 30% aqueous dispersion.

[0039] Enteric coating: take the soft capsule of Example 1 in a coating pan, and coat it under the condition that the spray gun pressure is 25-35psi, the inlet temperature is 50-60°C, and the coating pan rotating speed is 8rpm, until the coating is finished. Clothing weight gain of 7%.

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Abstract

The invention provides an enteric-coated soft capsule of Omega-3 aliphatic acid and its derivative. The enteric-coated soft capsule is nonsoluble in the stomach but can be dissolved in the intestinal tract to release active components. After soft capsule pressing shaping, the soft capsule is coated with an enteric coating; or gelatin, an enteric material, water and a plasticizer are used as raw materials, the enteric material and the gelatin liquid are mixed and then are plasticized to form a uniform mixture (which is an enteric solution) and the uniform mixture is further cured to form an enteric capsule shell material which is an enteric soft capsule gelatin sheet, the enteric capsule shell material is free of an enteric coating and has the enteric (acid-insoluble) characteristics, and the enteric soft gelatin sheet (enteric gelatin solution) has the characteristics of hot pressing or dropping encapsulation of contents.

Description

technical field [0001] The invention relates to an Omega-3 fatty acid and its derivative soft capsule and a preparation method thereof, in particular to the preparation of an enteric-coated soft capsule. technical background [0002] Omega-3 fatty acids and their derivatives can prevent cardiovascular disease, coronary heart disease, inflammatory diseases and cancer. It is generally developed into health care products, nutritional supplements and medicines on the market. Omega-3 fatty acids and their derivatives are liquid at room temperature. The products on the market generally have a fishy smell, which affects the taste, and its main component is eicosan Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) contain multiple double bonds, which are extremely sensitive to light, heat and oxygen, and usually require low temperature, airtight and light-proof storage. limit its application. Most of the products on the market are Omega-3 fatty acids and their derivatives...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/202A61P9/00A61P9/10A61P29/00A61P35/00
Inventor 朱海健刘强苏艺杰蔡林辉解建博叶英
Owner LP PHARM (XIAMEN) CO LTD