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Application of alisol G in preparation of medicine for preventing and treating obesity

A technology for obesity and alisol, which is applied to the application field of alisol G in medicine, can solve the problems of fecal incontinence, fatty stool, medication restriction and the like, and achieves the effect of satisfying clinical application, definite curative effect and clear composition.

Active Publication Date: 2014-07-09
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are drugs for the treatment of obesity, such as Xenical, but the drug has obvious side effects in the gastrointestinal tract, and it is easy to cause fatty stool and even fecal incontinence, which leads to the limitation of drug use
[0006] Chinese patent 200510106261.2 discloses a drug for the treatment of obesity. This patent mainly discloses the weight loss effect of Forsythia adenocarpus, but there are problems such as unclear effective material basis and insignificant weight loss effect.
However, there is no published literature on the effect of alisol G on weight loss

Method used

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  • Application of alisol G in preparation of medicine for preventing and treating obesity
  • Application of alisol G in preparation of medicine for preventing and treating obesity
  • Application of alisol G in preparation of medicine for preventing and treating obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Extraction of medicinal materials:

[0021] Method 1: Take 1 kg of dried tubers of Alisma orientalis (Sam.) Juzep., a plant of the family Alismaceae, make decoction pieces, and reflux extract with 7500ml of ethyl acetate twice, each time for 0.5 hours. The extracts were combined, and the solvent was recovered under reduced pressure to obtain 40 g of dark brown extract.

[0022] Method 2: Take 3 kilograms of dry tubers of Alisma orientalis (Sam.) Juzep., crushed into coarse particles, leak with 75% ethanol, combine the seepage, recover the solvent under reduced pressure, and obtain dark brown infusion Cream 110g.

[0023] Method 3: Take 2 kg of dry tubers of Alisma orientalis (Sam.) Juzep., crush them into coarse particles, and place them in CO 2 In supercritical extractor, extraction condition: CO 2 The pressure is 24-35MPa, the extraction temperature is 41-55°C, the extraction time is 1.5h, and 65g of dark brown extract is obtained.

[0024] Method 4: Take 1 kg of ...

Embodiment 2

[0026] Preparation of Alisitol G:

[0027] Method 1: Weigh 50g of the extract from Example 1, put it on a silica gel column (500g), elute with chloroform-methanol (4:1), 500ml is one fraction, detect by HPLC, collect the target fractions, and obtain solid 2.5 g, determined by the area normalization method, the purity is greater than 60% (weight).

[0028] Method 2: Weigh 10 g of the extract from Example 1, put it on D101 macroporous adsorption resin, elute with 20% ethanol for 10 column volumes, then use 70% ethanol to elute for 5 column volumes, and collect 70% ethanol to elute The solvent was recovered under reduced pressure to obtain 2 g of yellow oil; 2 g of yellow oil was dissolved in 65% methanol, and the target compound was separated by preparative HPLC. The separation conditions are: C18 column, mobile phase is 65% methanol, flow rate is 50ml / min, detection wavelength is 208nm. 100 mg of alisol G with a purity of 95% (by weight) was obtained as white needle crystals ...

Embodiment 3

[0032] Weigh 10 g of alisol G in Example 2, add 8 g of starch, 2 g of microcrystalline cellulose, and 0.2 g of magnesium stearate, mix well, and prepare tablets, capsules or granules by methods known in the art.

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Abstract

The invention discloses an application of alisol G in preparation of medicine for preventing and treating obesity. The animal tests prove that alisol G has obvious treatment effect for an obesity model due to high-fat diet feeding. By using a modern medicine theory, the medicine for treating obesity has the advantages of definite therapeutic effect, clear component and controllable quality. The medicine has obvious weight reduction, fat reduction and obesity prevention effects, and can satisfy the requirement of clinical application.

Description

technical field [0001] The present invention relates to the application of alisol G in medicine. Background technique [0002] With the improvement of people's living standards, the incidence of obesity is also increasing. [0003] Obesity is generally divided into two categories, one is obesity caused by disease, which is obesity caused by endocrine disorders caused by diseases (encephalitis, brain tumor, arthritis or chronic diseases requiring hormones). Symptomatic obesity. This type of obese patients accounts for about 5% of the total obese people. [0004] Another type of obesity is due to the intake of calories during the diet, which greatly exceeds the calories consumed by itself. And excess fat and other nutrients are accumulated in the body to form fat cells, which leads to obesity. People who belong to this type of obesity become simple obesity, accounting for more than 90% of the total number of obese people. [0005] At present, there are drugs for the treatm...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P3/04
Inventor 侯惠民程志红
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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