Preparation method of glucose sensor based on composite material

A technology of glucose sensor and nanocomposite materials, which is applied to the analysis of materials, electrochemical variables of materials, and material analysis through electromagnetic means. It can solve the problems of complex preparation process and many influencing factors, and achieve easy preparation and wide linearity. range, excellent reproducible results

Inactive Publication Date: 2014-07-16
YANGZHOU UNIV
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Problems solved by technology

Among them, the hydrothermal method and the microemulsion method produce smaller and uniform particle sizes, but the preparation process is complicated and there are many influencing factors.

Method used

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  • Preparation method of glucose sensor based on composite material
  • Preparation method of glucose sensor based on composite material
  • Preparation method of glucose sensor based on composite material

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0029] 1. Preparation of Fe 3 o 4 Magnetic nanoparticles:

[0030] Fe3O4 nanoparticles were synthesized by Massart co-precipitation method. That is, in an alkaline environment, iron ions and ferrous ions co-precipitate to form Fe 3 o 4 . Synthesis principle:

[0031]

[0032] The whole experiment was carried out in a nitrogen atmosphere, FeCl 2 and FeCl 3 (Concentration molar ratio is 1:2) Mix well, then slowly add excess 25% concentrated ammonia water, the reaction temperature is 80°C, stir continuously for 20min, stop the reaction, separate the solid phase of the obtained product from the reactant with a magnet, and washed three times with ethanol and water to obtain Fe 3 o 4 magnetic nanoparticles.

[0033] Made of Fe 3 o 4 XRD of magnetic nanoparticles such as figure 1 Shown in curve a.

[0034] 2. Preparation of casein-modified Fe 3 o 4 Composite nanoparticles:

[0035] Take 10 mL of casein (casein) aqueous solution with a concentration of 10 mg / mL and s...

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Abstract

The invention relates to a preparation method of a glucose sensor based on a composite material, which belongs to the technical field of electrochemical analysis and detection. Core-shell Fe3O4@Au composite particles are prepared by adopting casein as a stabilizer and a reducing agent through a chemical reduction method, and the preparation method has the advantages of simplicity in preparation, easily available raw materials, good biological compatibility and favorability for fixing biological enzyme; then glucose oxidase is fixed on the surface of the core-shell Fe3O4.Au composite particles to modify an electrode so as to prepare the Fe3O4@Au glucose biological sensor. The synthesis method is simple, low in cost and pollution-free. When being used for detecting the glucose, the sensor is short in response time, wide in linear range, low in detection limit, high in sensitivity and good in selectivity. The sensor is excellent in reproducibility, good in interference resistance and good in long-term stability.

Description

technical field [0001] The invention belongs to the technical field of electrochemical analysis and detection, in particular to 3 o 4 Techniques for the preparation and application of Au nanocomposite glucose sensors. Background technique [0002] With the rapid development of society and the improvement of people's living standards, the prevalence of diabetes has also increased. According to the report of the World Health Organization, there are currently 346 million people suffering from diabetes. Real-time and reliable detection of blood sugar concentration is the key to diagnosis and control. Effective approach to diabetes. [0003] Electrochemical sensors are widely used in the electrochemical detection of living substances due to their advantages such as high sensitivity, good selectivity, simple and fast experiments, and low cost of required instruments and equipment. It is of great scientific significance and use value to develop a high-sensitivity glucose sensor ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327G01N27/26
Inventor 刘燕毛慧渊袁敏郭荣
Owner YANGZHOU UNIV
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