Application of Viper Venom in the Preparation of Antiangiogenic Drugs

An anti-angiogenesis and snake venom technology, applied in the field of traditional Chinese medicine, can solve the problems of unfavorable industrialized production and promotion, complicated preparation process, small application range, etc., and achieve the effects of being beneficial to industrialized production and popularization, simple operation, and remarkable curative effect.

Active Publication Date: 2018-11-13
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the above scheme discloses the cobra snake venom after physical modification to treat and inhibit inflammatory pain, inflammatory hyperplasia and adjuvant arthritis, the application range of the treatment is small, the preparation process is complicated, and alcohol detoxification is required, so the practicability is poor. Not conducive to industrial production and promotion

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  • Application of Viper Venom in the Preparation of Antiangiogenic Drugs
  • Application of Viper Venom in the Preparation of Antiangiogenic Drugs
  • Application of Viper Venom in the Preparation of Antiangiogenic Drugs

Examples

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Embodiment 1

[0022]Application of Viper venom in the preparation of anti-angiogenesis drugs. More specifically, Agletus venom acts as a VEGF inhibitor against angiogenesis; or Aggresis venom acts as an anti-angiogenic Ang-1 inhibitor; Inhibitors.

[0023] An anti-angiogenic drug containing Viper venom. The medicine comprises the Viper venom and a pharmaceutically acceptable carrier. In this example, the Viper venom is a freeze-dried powder formed by sublimation and drying. The freeze-dried powder is made into an injection containing 0.1-1.0 mg / kg body weight of Viper venom.

[0024] The application of an anti-angiogenic drug containing Agkistrodon venom for treating related diseases. Associated diseases include intraocular neovascularization, psoriasis, tumors, arteriosclerosis, inflammatory diseases and endometriosis, complications of diabetes. Furthermore, the inflammatory disease is preferably rheumatoid arthritis and rheumatoid arthritis. Due to intraocular neovascularization, ps...

Embodiment 2

[0049] Two, the animal experiment 1 of embodiment 2 of the present invention is as follows (taking rat rheumatoid arthritis as example):

[0050] Animal experiment 1

[0051]1.1 Animals 48 SPF-grade Lewis rats, female, 8-9 weeks old, weighing (150 10) g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., and were bred in the Experimental Animal Center of Zhejiang University of Traditional Chinese Medicine. The room temperature is 20°C, the relative humidity is 40% to 60%, the light is 12 hours a day, and food and water are freely available.

[0052] 1.2 Drugs The lyophilized powder of Viper venom was purchased from Huangshan Snake Science Research Institute; Mokebi (meloxicam tablets 7.5 mg, product batch number 284177) was a product of Shanghai Boehringer Ingelheim Pharmaceutical Co., Ltd.

[0053] 1.3 Reagents and instruments Bovine type Ⅱ collagen (CⅡ), complete Freund's adjuvant (CFA), and incomplete Freund's adjuvant (IFA) are all product...

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Abstract

Belonging to the technical field of traditional Chinese medicines, the invention especially relates to application of long-nosed pit viper venom in preparation of an anti-angiogenesis drug, and solves the technical problems of unobvious curative effect, high price and the like of anti-angiogenesis drugs. The invention provides a long-nosed pit viper venom containing anti-angiogenesis drug characterized by controllable quality, small dosage, convenient use, safety and reliability, and provides application of the long-nosed pit viper venom containing anti-angiogenesis drug in treatment of related diseases. Compared with anti-angiogenic biological agents, the long-nosed pit viper venom is cheaper and is easily available. The lyophilization method is easy to operate, and pure long-nosed pit viper venom lyophilized powder can be easily obtained and has a significant anti-angiogenic effect. Thus, the long-nosed pit viper venom can be applied in various vascular proliferation related diseases, has the advantages of wide application range, significant curative effect, strong utility, and is beneficial to industrial production and promotion.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to the application of Viper venom in the preparation of anti-angiogenesis drugs. Background technique [0002] Angiogenesis is the result of the joint action of many factors. Taking the angiogenesis of inflammatory lesions as an example, the formation of new blood vessels is divided into three steps: activation of endothelial cells by inflammatory mediators; degradation of vascular endothelial matrix by proteases; chemotaxis of endothelial cells and angiogenesis. VEGF is the abbreviation of vascular endothelial growth factor (vascular endothelial growth factor), which was also called vascular permeability factor (vascular permeability factor) in the early stage. It is a heparin-binding growth factor specific for vascular endothelial cells and can induce angiogenesis in vivo. VEGF is the main angiogenesis factor, which can stimulate the survival, mig...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/583A61P27/02A61P17/06A61P35/00A61P9/10A61P29/00A61P15/00A61P3/10
Inventor 储利胜陶方方范永升汪丽佩丁志山曲铁兵李琳
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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