Chitosan biological medical glue for promoting human epidermal growth and preparation method of biological medical glue

A biomedical technology for epidermal growth, applied in the field of medical glue, can solve the problems of difficult observation of wound healing, poor surgical efficacy, and large wound area, so as to promote the formation of fibroblasts and upper epidermal cells, reduce wound inflammation, The effect of good histocompatibility

Active Publication Date: 2014-07-23
GUANGXI XINYE BIOLOGICAL TECH
View PDF3 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Superficial abrasions on the skin surface are a common type of trauma in the clinical work of plastic surgery. They have a large trauma area, are prone to infection, and have poor surgical efficacy; the conventional dressing change course is long and the efficacy is not certain; after healing, the lesions tend to form scars, Pigment changes and other sequelae, causing great harm to the patient's body and mind
[0003] The traditional treatment of burns, scalds and cosmetic plastic wounds uses bandage therapy, which is inconvenient to operate, difficult...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] A chitosan promotes human epidermal growth biomedical glue, and every liter of chitosan promotes human epidermal growth biomedical glue includes the following raw materials:

[0075] Modified Chitosan 100g

[0076] Nano silver 4mg

[0077] Human Collagen 80g

[0078] Glycerin 10g

[0079] Epidermal Growth Factor 1×10 -4 g

[0080] Viscosity modifier 0.1g

[0081] Cross-linking agent 4g.

[0082] The modified chitosan is chitosan hydrochloride with a degree of deacetylation of 70%.

[0083] The viscosity modifier is carbomer.

[0084] The cross-linking agent is genipin.

[0085] A preparation method of chitosan promoting human epidermal growth biomedical glue, which comprises the following preparation steps:

[0086] A, each raw material is weighed according to formula quantity, standby;

[0087] B, disperse the modified chitosan of formula quantity in purified water, after stirring evenly, add the nano-silver and glycerin of formula quantity, make mixed liquor...

Embodiment 2

[0091] A chitosan promotes human epidermal growth biomedical glue, and every liter of chitosan promotes human epidermal growth biomedical glue includes the following raw materials:

[0092] Modified Chitosan 40g

[0093] Nano Silver 10000mg

[0094] Human Collagen 30g

[0095] Glycerin 300g

[0096] Epidermal Growth Factor 1×10 -2 g

[0097] Viscosity modifier 10g

[0098] Cross-linking agent 2g.

[0099] The modified chitosan is chitosan hydrochloride with a degree of deacetylation of 95%.

[0100] The viscosity regulator is a mixture of hydroxypropyl methylcellulose and gellan gum in a weight ratio of 2:1.

[0101] The cross-linking agent is genipin.

[0102] Every liter of chitosan biomedical glue for promoting human epidermal growth also includes 5-30g of plant extracts, and the plant extracts include the following raw materials in parts by weight:

[0103] Angelica 30 servings

[0104] Licorice 20 parts

[0105] Angelica dahurica 10 parts

[0106] Red hair sev...

Embodiment 3

[0116] A chitosan promotes human epidermal growth biomedical glue, and every liter of chitosan promotes human epidermal growth biomedical glue includes the following raw materials:

[0117] Modified Chitosan 50g

[0118] Nano Silver 9000mg

[0119] Human Collagen 50g

[0120] Glycerin 200g

[0121] Epidermal Growth Factor 0.05g

[0122] Viscosity modifier 100g

[0123] Cross-linking agent 2g.

[0124] The modified chitosan is carboxymethyl chitosan with a carboxylation degree of 90%.

[0125] The viscosity regulator is a mixture of hydroxypropyl methylcellulose, exopolysaccharide gum and pullulan in a weight ratio of 1:1:1.

[0126] The cross-linking agent is genipin.

[0127] Every liter of chitosan biomedical glue for promoting human epidermal growth also includes 5-30g of plant extracts, and the plant extracts include the following raw materials in parts by weight:

[0128] Angelica 45 servings

[0129] Licorice 30 parts

[0130] Angelica dahurica 25 parts

[013...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Growth factoraaaaaaaaaa
Growth factoraaaaaaaaaa
Growth factoraaaaaaaaaa
Login to view more

Abstract

The invention relates to the technical field of medical glue and in particular relates to chitosan biological medical glue for promoting human epidermal growth and a preparation method of the biological medical glue. The chitosan biological medical glue comprises the following raw materials in parts by weight: 10-100g of modified chitosan, 4-20000mg of nano-silver, 1-80g of human-like collagen, 10-400g of glycerol, 0.0001-0.1g of epidermal growth factor, 0.1-200g of viscosity regulator, 0.5-4g of cross-linking agent and the balance of purified water. Main and auxiliary materials take a synergistic effect to form a drug delivering system with a slow release function, thereby improving the availability of active substances; the chitosan biological medical glue is attached close to the uneven wound surface, but the chitosan biological medical glue does not stick to the uneven wound surface. The chitosan biological medical glue is excellent in biocompatibility, strong in antisepsis and anti-inflammation, free of local stimulation and systemic adverse reaction, colorless and transparent, conducive to wound observation, capable of quickly promoting the repair of the wound surface, suppressing and reducing the generation of scar and widely applicable to the treatment of infected wound, operative incisions, all burns, scalds and wounds.

Description

technical field [0001] The invention relates to the technical field of medical glue, in particular to a chitosan biomedical glue for promoting human epidermal growth and a preparation method thereof. Background technique [0002] Superficial abrasion on the skin surface is a common type of trauma in plastic surgery clinical work. It has a large trauma area, is prone to infection, and has poor surgical curative effect; and the conventional dressing change course is long, and the curative effect is not sure; Pigment changes and other sequelae are very harmful to the patient's body and mind. [0003] The traditional treatment of burns and scalds and cosmetic plastic wounds uses bandage therapy, which is inconvenient to operate and difficult to observe the wound healing, poor in infection control, and often causes secondary mechanical damage, which not only brings pain to patients, but also causes wound damage. Potential infection, affecting wound healing. Although there are c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L15/32A61L15/28A61L15/20A61L15/44A61L15/42
Inventor 梁奕福
Owner GUANGXI XINYE BIOLOGICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap