O-fumarate-N-trimethyl chitosan quaternary ammonium salt as well as preparation method and application thereof
A technology of trimethyl chitosan and fumarate, applied in the directions of applications, botanical equipment and methods, chemicals for biological control, etc., can solve problems such as limiting antibacterial applications, and achieve enhanced antibacterial activity and hydrophilicity. performance, expand the scope of application, good antibacterial effect
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Embodiment 1
[0030] A kind of O-fumarate-N-trimethyl chitosan quaternary ammonium salt, preparation method is as follows:
[0031] (1) Dissolve 4g of chitosan in a mixture of 200mL deionized water and 15mL formic acid, stir and heat up to 70°C, add 10mL of formaldehyde solution, mix well and transfer to a microwave normal pressure reactor, adjust the microwave Power to 400W, temperature 30°C, react for 240min; use 15% NaOH solution to adjust pH to alkaline, filter with suction, wash with water until neutral, dry and add to 50mL N-methyl-2-pyrrolidone (NMP), Add 20mL methyl iodide, react at 40°C for 120h; add twice the volume of V (ether) / V (ethanol) = 1:1 mixed solvent for precipitation, use deionized water to dialyze and freeze-dry to obtain N-trimethyl chitosan sugar.
[0032] The substitution degree of N-trimethyl chitosan quaternary ammonium salt is 66% through photoelectron spectroscopy quantitative analysis (XPS) for C and N element analysis.
[0033] (2) Disperse 1.16g of fumaric ...
Embodiment 2
[0036] A kind of O-fumarate-N-trimethyl chitosan quaternary ammonium salt, preparation method is as follows:
[0037] (1) Dissolve 4g of chitosan in a mixture of 200mL deionized water and 15mL formic acid, stir and heat up to 70°C, add 10mL of formaldehyde solution, mix well and transfer to a microwave normal pressure reactor, adjust the microwave power React at a temperature of 500W and 40°C for 180min; adjust the pH to alkaline with 15% NaOH solution, filter with suction, wash with water until neutral, add to 50mL of N-methyl-2-pyrrolidone after drying, add 40mL of methyl iodide , react at 40° C. for 120 h; add twice the volume of V (ether) / V (ethanol) = 1:1 mixed solvent for precipitation, use deionized water to dialyze and freeze-dry to obtain N-trimethyl chitosan.
[0038] The substitution degree of N-trimethyl chitosan quaternary ammonium salt is 69% through photoelectron spectroscopy quantitative analysis (XPS) for C and N element analysis.
[0039] (2) Disperse 2.32g ...
Embodiment 3
[0042] A kind of O-fumarate-N-trimethyl chitosan quaternary ammonium salt, preparation method is as follows:
[0043] (1) Dissolve 4g of chitosan in a mixture of 200mL deionized water and 15mL formic acid, stir and heat up to 70°C, add 10mL of formaldehyde solution, mix well and transfer to a microwave normal pressure reactor, adjust the microwave power React at a temperature of 600W at 50°C for 120min; adjust the pH to alkaline with 15% NaOH solution, filter with suction, wash with water until neutral, add to 50mL of N-methyl-2-pyrrolidone after drying, add 60mL of methyl iodide , react at 40° C. for 120 h; add twice the volume of V (ether) / V (ethanol) = 1:1 mixed solvent for precipitation, use deionized water to dialyze and freeze-dry to obtain N-trimethyl chitosan.
[0044] The substitution degree of N-trimethyl chitosan quaternary ammonium salt is 73% through photoelectron spectroscopy quantitative analysis (XPS) for C and N element analysis.
[0045] (2) Take 3.48g of fu...
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