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Concentration determining method of arecoline hydrobromide in animal blood plasma

A technology for the determination of arecoline hydrobromide, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of low sensitivity, weak ultraviolet absorption, etc., and achieve short analysis time, low detection limit, and accurate content determination results Effect

Inactive Publication Date: 2014-07-23
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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Problems solved by technology

Since the maximum ultraviolet absorption wavelength of arecoline hydrobromide is 215nm, which belongs to the terminal absorption, the ultraviolet absorption is very weak, the sensitivity of high performance cation exchange chromatography and high performance liquid chromatography-ultraviolet detection method is not high, and there is currently no arecoline hydrobromide in animal plasma Report on detection method

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  • Concentration determining method of arecoline hydrobromide in animal blood plasma

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Abstract

The invention relates to a concentration determining method of arecoline hydrobromide in animal blood plasma. The method applies high performance liquid chromatography-tandem mass spectrum technology for concentration determination of the arecoline hydrobromide in the animal blood plasma. Beta-pinene is adopted as an internal standard substance, and the concentration of the arecoline hydrobromide in the animal blood plasma can be accurately determined. The high performance liquid chromatography-tandem mass spectrum process which is rapid, accurate and sensitive is adopted for the concentration determination of the arecoline hydrobromide in the animal blood plasma. The method is high in specificity and good in separation effect. Linearity, stability, reproducibility, and recovery tests of the method satisfy good technical requirements. The method lays methodology foundations for research of pharmacokinetics and bioequivalence of the medicine inside animals.

Description

[0001] technical field [0002] The invention belongs to the field of drug analysis and relates to a method for quantitatively measuring the content of arecoline hydrobromide in animal plasma. [0003] Background technique [0002] Arecoline is one of the active ingredients in the traditional Chinese medicine betel nut. It is mainly used in veterinary clinics to treat tapeworms, sluggish bovine stomach, and equine animals such as gastric dilatation, large intestine obstruction, and intestinal paralysis. In addition, the synergistic effect of arecoline on molluscicide can significantly reduce the dosage of chemical molluscicide, thereby reducing the pollution to the environment. Because arecoline has obvious side effects when applied to animals, its use on important economical animals and pets is limited. Arecoline and its hydrobromide have a good effect of promoting gastrointestinal motility and deworming effect. Arecoline hydrobromide has the effect of repelling various ...

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Application Information

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IPC IPC(8): G01N30/88
Inventor 李冰张继瑜周绪正牛建荣魏小娟李金善李剑勇杨亚军刘希望
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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