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Preparation method of high molecular polymer micro-fluidic chip

A high molecular polymer, microfluidic chip technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc. problems, to achieve the effect of being conducive to mass production, realizing functional diversification, and reducing production costs

Active Publication Date: 2014-08-06
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still certain defects, such as the elasticity and thermal expansion of materials in processing, which make it difficult to obtain high accuracy, and also limit the use of soft lithography in multi-level micromachining, because the elastic mold is too soft to obtain Large aspect ratio, too large or too small aspect ratio will lead to deformation and distortion of the microstructure
[0008] In summary, the hot pressing method, molding method, injection molding method, and soft etching method mainly depend on the properties of the mold, and the disadvantages of the mold such as short service life or high price greatly limit the promotion of these technologies, while laser ablation The production efficiency of the method is low, the price is expensive, and it is difficult to mass-produce polymer microfluidic polymer chips

Method used

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  • Preparation method of high molecular polymer micro-fluidic chip
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  • Preparation method of high molecular polymer micro-fluidic chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Such as figure 1 As shown, the classic cross-shaped chip electrophoresis chip (upper) and the cross-shaped chip with added separation channels (lower), the channel width is 100 microns, and the depth is 80 microns.

[0045] Its preparation process steps are:

[0046] 1) Use numerical control software to design the channel of the microfluidic chip, obtain the corresponding engraving path, and write the engraving code for engraving;

[0047] 2) Import the engraving code into the software that controls the engraving machine, and engrave the polymer material to be produced;

[0048] 3) After engraving, according to different requirements, the chip is sealed to obtain a functional microfluidic chip.

[0049] In the step 2), when engraving the polymer material, the size of the engraving knife is 100 μm, fix the polymer material to be produced on the CNC engraving machine platform, select the appropriate initial engraving coordinates, set The rotation speed is 5000r / min, the...

Embodiment 2

[0052] Such as image 3 As shown, the chip of the microreactor, the chip includes two sample inlets, one product outlet, the channel width is 100 microns, the depth is 80 microns, the effective reaction distance is 54 cm, and the chip size is only 1.8 cm × 7 cm.

[0053] The manufacturing process is basically the same as that of Example 1, except that: in the step 2), when engraving the polymer material, the size of the engraving knife is 100 μm, select the appropriate initial engraving coordinates, and set the rotation speed to 7000r / min, the speed is 50mm / min, the coolant is a mixture of ethanol and ethylene glycol (volume ratio 1:1), and the cycle starts.

Embodiment 3

[0055] Such as Figure 4 As shown, the schematic diagrams of several types of chips used to characterize the effect of solution mixing, to prove that the chips made by the engraving machine have no obstacles to the mixing of solutions, and the channel width is designed to be 200 μm and the depth is 80 μm.

[0056] The production process is basically the same as that of Example 1, except that in the step 2), when engraving the polymer material, the size of the engraving knife is 200 μm, and the polymer material to be produced is fixed on the engraving On the machine platform, select the appropriate initial engraving coordinates, set the rotation speed to 5000r / min, the speed to 50mm / min, add a mixture of ethanol and ethylene glycol (volume ratio 1:1) as the cooling liquid, and the cycle starts.

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Abstract

The invention discloses a preparation method of a high molecular polymer micro-fluidic chip, which is characterized in that a CNC engraving machine is utilized for direct machining of micro-fluidic equipment. In the application, the micro-fluidic chip is prepared by using the method of a numerical control machine tool engraving machine engraving polymer materials, so that the production cost of the high molecular polymer micro-fluidic chip is greatly reduced when compared with the method in the prior art, the depth of a micro channel of the chip can be flexibly adjusted, and the method is simple, easy to use, and beneficial to mass production of the chip.

Description

technical field [0001] The invention relates to a microfluidic chip fabrication technology, which is mainly used for the fabrication of high molecular polymer microfluidic chips. Background technique [0002] The manufacturing technologies of polymer microfluidic chips mainly include hot pressing method, molding method, injection molding method, laser ablation method, LIGA technology, soft etching method, etc. [0003] The hot pressing method is a widely used chip fabrication technology for rapidly replicating electrophoretic microchannels. In the hot pressing method, the properties of the mold, such as surface roughness, hardness, and direct friction coefficient with the substrate material, directly determine the quality of the obtained microchannels. [0004] The main steps of the molding method are, firstly, adopt photolithography and etching to manufacture the positive mold of microchannel concavity, and then pour liquid high molecular polymer on the positive mold, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 蒲巧生杨升宏吴晶
Owner LANZHOU UNIVERSITY
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