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Medicine for local anaesthesia and preparation method of medicine

A technology of local anesthesia and drugs, applied in anesthetics, drug combinations, pharmaceutical formulas, etc., to achieve good pain and hemostatic effects, no toxic and side effects, and the effect of eliminating fear

Inactive Publication Date: 2014-08-20
王永
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These fears and reactions occur from time to time, which bring a lot of trouble to the doctor's work and make the patient feel pain. Moreover, the existing western medicine anesthesia still has anesthesia risk

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0058] Wherein, when the dosage form of the drug is a tincture, the preparation method includes the following steps:

[0059] In the first step, the raw medicinal materials are mixed according to the proportions, and are pulverized into a mixture of micron-sized particles with a volume average particle diameter of 0.1-10 μm and nano-sized particles with a volume average particle diameter of less than 0.1 μm in an ultrafine pulverizer. Powder, the powder yield of the mixed powder is at least 90%;

[0060] In the second step, the mixed powder obtained in the first step is added with 4 to 8 times the mass of the mixed powder with ethanol with an alcohol concentration of 85%-95%, stirred and dissolved to obtain an ethanol solution, and the ethanol solution is Let stand for 30-60 hours under the condition of 4℃~6℃, use the percolation method to slowly percolate at the speed of 1~2ml per minute, collect the percolate, concentrate and dry, and put it in the superfine grinder. Medium pulv...

Embodiment 1

[0069] Example 1 Tincture

[0070] Take Angelica sinensis 16g, cinnamon 12g, Chinese pepper 19g, ginger 19g, Nepeta 9g, parsnip 14g, clove 12g, tangerine peel 17g, Radix aconiti 12g, mimosa 11g, Gansong 12g, persimmon stalk 11 g, mint 10 g, Bupleurum g, scopole leaves 4 g, gentian 13 g, coptis 19 g, horse money seed 3 g, patella 11 g, purslane 13 g, eucalyptus 12 g, white flower Oldenlandia diffusa 10 g, Habitat 9 g, Artemisia annua 11 g, Digu skin 9 g, Panax notoginseng 10 g, Madder 10 g, Loropetalum 14 g, Wulingzhi 16 g and Corydalis 15 g;

[0071] The preparation method includes the following steps:

[0072] In the first step, the raw medicinal materials are mixed according to the proportions, and put into an ultrafine pulverizer to pulverize into a mixed powder composed of micron particles with a volume average particle diameter of 5 μm and nano particles with a volume average particle diameter of less than 0.1 μm , The powder yield rate of the mixed powder is at least 90%;

[0...

Embodiment 2

[0076] Example 2 Smear

[0077] Take Angelica sinensis 17g, cinnamon 14g, Chinese pepper 20g, ginger 18g, Nepeta 8g, parsnip 15g, clove 13g, tangerine peel 18g, Radix aconiti 14g, mimosa 13g, Gansong 8g, persimmon stalk 14 g, peppermint 8 g, Bupleurum 15 g, scopole leaves 2 g, gentian 14 g, coptis 18 g, horse money seed 2 g, patella 8 g, purslane 16 g, and eucalyptus 11 g, Oldenlandia diffusa 8 g, Habitat 8 g, Artemisia annua 9 g, Digu skin 8 g, Panax notoginseng 9 g, Madder 12 g, Loropetalum 15 g, Wulingzhi 15 g, and Corydalis 18 g.

[0078] The preparation method includes the following steps:

[0079] Step 1: First crush the raw materials into coarse powder, then further crush, pass a 200-mesh sieve, so that the amount of fine powder that can pass through the 200-mesh sieve reaches at least 60%, and collect the fine powder that passes through the 200-mesh sieve to obtain fine powder a ;

[0080] Step 2: Put the coarse powder that cannot pass the 200-mesh sieve into the multifuncti...

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Abstract

The invention discloses a medicine for local anaesthesia and a preparation method of the medicine. The medicine comprises the following raw material medicines: Chinese angelica, cinnamon, pepper, fresh ginger, Schizonepeta, divaricate saposhnikovia root, clove, dried tangerine or orange peel, cyperus rotundus, sensitive plant, rhizoma nardostachyos, persimmon calyx, mint, radix bupleuri, henbane leaf, radix gentianae, coptis chinensis, semen strychni, patrinia, purslane, humifuse euphorbia herb, oldenlandia diffusa, root of rehmannia, sweet wormwood, cortex lycii radicis, pseudo-ginseng, rubia cordifolia, Loropetalum chinense, trogopterus dung and corydalis tuber. The medicine has the beneficial effects that the medicine has the advantages of wide clinical application safety range, zero toxic or side effect and good pain and blood stopping effects by utilizing the theory of traditional Chinese medicine, injection is not needed during use, only the medicine is needed to be dripped or smeared to an affected part needed to be operated for several times, and when the local tissue is found not to have a sense of pain, the operation can be carried out. The feared state of mind of a patient can be effectively eliminated, the feeling of the patient can be rapidly restored after the operation, and postoperative adverse reactions are reduced.

Description

[0001] Technical field [0002] The present invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for local anesthesia and a preparation method thereof. [0003] Background technique [0004] In clinical operations, anesthesia is a variety of methods used to eliminate pain, ensure patient safety, and create good surgical conditions during surgery or diagnostic examination operations. The patient feels pain during surgery or diagnostic examination and needs to be temporarily unconscious with anesthetics or other means. Surgery or examination operations can also cause mental stress or reflex adverse reactions in patients. At present, hospitals often use injections such as procaine for local anesthesia. For example, in dentistry, there are many patients whose primary teeth are replaced with teeth, wisdom teeth, and diseased teeth need to be removed. , Adverse reactions caused by fear of injections such as paleness, palpitation, chest ti...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P23/02A61K35/24
Inventor 王永
Owner 王永
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