Night type traditional Chinese medicine cough-relieving buccal tablet and preparation method thereof

Abstract

The invention relates to a night type traditional Chinese medicine cough-relieving buccal tablet and a preparation method thereof. The night type traditional Chinese medicine cough-relieving buccal tablet is prepared by extracting volatile oil from mint whole plant, cacumen biotae and salvia plebeian according to a proportion of 1:1:2. The cough-relieving buccal tablet is suitable for night cough. The preparation method comprises the steps of feeding materials; extracting the volatile oil; weighing; taking beta-cyclodextrin with an amount of 8-10 times that of the volatile oil; stirring into paste with pure water with an amount of 2-3 times that of beta-cyclodextrin; adding the volatile oil; stirring for 2-3 h at a constant temperature ranging from 45 DEG C to 50 DEG C; drying the paste for 3-4 h in vacuum; smashing and screening with a 80-100 mesh sieve; preparing materials according to a ratio of inclusion complex to glucose to mannitol to citric acid to starch to talcum powder being 60:20:3:2:8:3; mixing glucose, mannitol and citric acid; adding 15%-20% (g/g) of starch paste; granulating in one step; shaping particles to 14 meshes; adding the talcum powder; mixing uniformly; tabletting; and detecting according to pharmacopeia standards, the content being over 7.5%.

Description

technical field [0001] The invention relates to a cough-relieving pharmaceutical composition, in particular to a cough-relieving buccal tablet suitable for nighttime use made from Chinese herbal medicines and a preparation technology thereof. Background technique [0002] Cough is a common complaint in respiratory medicine. According to the course of the disease, cough is usually divided into acute cough (<3 weeks), subacute cough (3-8 weeks) and chronic cough (>8 weeks) [1] . Among them, chronic cough is also called unexplained cough, cough is the only symptom or the main symptom, and the chest X-ray shows no obvious abnormalities. The main causes are postnasal drip syndrome (PNDs), cough variant asthma (CVA), gastroesophageal reflux (GER), allergic cough (AC) and eosinophilic bronchitis (EB), etc. , of which CVA-type nocturnal cough accounts for more than 80%, and other types of nocturnal cough account for 25-30% [2] . Nocturnal cough occurs at a special time, wh...

AI Technical Summary

Problems solved by technology

The traditional Chinese medicine mint, arborvitae leaves, and lychee grass involved in the present invention are all traditional Chinese medicines for treating sore throat, anti-inflammatory and cough-relieving drugs. They are used as a single prescription in the folk, and they are both used as medicine and food. They have obvious effects in treating cough, but they have disadvantages such as inconvenient operation and lack of synergy in curative effect.

Clinically, the traditional cough-relieving tablets and capsules can exert their curative effect 1 hour after oral administration. Oral liquids and syrups stay in the mouth for a short time, which can temporarily relieve cough and last for a short time.

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