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Method for preparing guaiacyl glycerol-(8-O-4')-guaiacyl glycerol

A wood-based glycerol, 8-O-4 technology, used in ether preparation, ether separation/purification, organic chemistry, etc. The effect of continuous development

Active Publication Date: 2014-08-27
SOUTH CHINA BOTANICAL GARDEN CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that lychee core and lychee shell are rich in flavonoids, which have biological activities such as anti-oxidation, anti-cancer, and hypoglycemic. However, the current research on the active ingredients of lychee leaves is very limited, and the composition of related active substances still needs to be studied

Method used

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  • Method for preparing guaiacyl glycerol-(8-O-4')-guaiacyl glycerol
  • Method for preparing guaiacyl glycerol-(8-O-4')-guaiacyl glycerol

Examples

Experimental program
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Effect test

Embodiment 1

[0014] Example 1: Preparation, isolation and structural identification of guaiacylglycerol-(8-O-4')-guaiacylglycerol.

[0015] One, the preparation and separation of guaiacylglycerol-(8-O-4')-guaiacylglycerol

[0016] 1) Material selection: choose fresh lychee leaves, wash with water;

[0017] 2) drying and pulverizing: drying or drying the lychee leaves, using a pulverizer to pulverize them into powder, and passing through a 20-mesh sieve to obtain the lychee leaf powder;

[0018] 3) Leaching: Add 5 times the volume of litchi leaf powder (ie 5 mL / g litchi leaf powder) to methanol aqueous solution with a volume fraction of 40%, extract at 80° C. for 4 hours, filter, and collect the filtrate;

[0019] 4) Organic solvent classification: Concentrate the above filtrate at 40°C to remove methanol, add 1 times its volume of water, and extract with equal volumes of petroleum ether and ethyl acetate for 3 times; select the ethyl acetate phase extract to concentrate Extraction was ob...

Embodiment 2

[0029] 1) Material selection: choose fresh lychee leaves, wash with water;

[0030] 2) Drying and pulverizing: drying or drying the lychee leaves, using a pulverizer to pulverize them into powder, and passing through a 120-mesh sieve to obtain the lychee leaf powder;

[0031] 3) Leaching: adding 20 times the volume of litchi leaf powder (ie 20 mL / g litchi leaf powder) to a 90% methanol solution, extracting at room temperature for 35 hours, filtering, and collecting the filtrate;

[0032] 4) Organic solvent classification: Concentrate the above-mentioned filtrate at 60°C to remove methanol, add 3 times the volume of water, and extract 12 times with equal volumes of petroleum ether and ethyl acetate; select the ethyl acetate phase extract to concentrate The extract was obtained for subsequent purification.

[0033] Subsequent purification steps were the same as in Example 1, whereby the compound was obtained and identified as guaiacylglycerol-(8-O-4')-guaiacolglycerol.

[0034...

Embodiment 3

[0036] 1) Material selection: choose fresh lychee leaves, wash with water;

[0037] 2) drying and crushing: dry or dry the lychee leaves, use a pulverizer to pulverize them into powder, and pass through a 60-mesh sieve to obtain the lychee leaf powder;

[0038] 3) Leaching: adding 10 times the volume of litchi leaf powder (ie 10 mL / g litchi leaf powder) to a 40% aqueous ethanol solution, extracting at 50°C for 20 hours, filtering, and collecting the filtrate;

[0039] 4) Organic solvent classification: Concentrate the above-mentioned filtrate at 60°C to remove ethanol, add 2 times the volume of water, and extract 6 times with equal volumes of petroleum ether and ethyl acetate; select the ethyl acetate phase extract to concentrate The extract was obtained for subsequent purification.

[0040] Subsequent purification steps were the same as in Example 1, and the compound was obtained and identified as guaiacylglycerol-(8-O-4')-guaiacylglycerol.

[0041] The yield of guaiacylgly...

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Abstract

The invention discloses a method for preparing guaiacyl glycerol-(8-O-4')-guaiacyl glycerol. The structural formula of guaiacyl glycerol-(8-O-4')-guaiacyl glycerol is as shown in formula (I). According to the invention, a lot of guaiacyl glycerol-(8-O-4')-guaiacyl glycerol is prepared and separated from lichee leaves, and the yield is 10-56 mg / kg (the purity is 85-95%). The method of the invention has important significance on promoting lichee deep processing and utilization, increasing the added value lichee products, and promoting the sustainable development of the industry.

Description

technical field [0001] The invention belongs to the field of natural products, and in particular relates to a method for preparing and separating guaiacylglycerol-(8-O-4')-guaiacylglycerol from litchi leaves. Background of the invention [0002] Litchi belongs to Sapindaceae, known as "Lingnan Fruit King", and is one of the four famous fruits in Guangdong. Litchi is sweet and delicious, with high nutritional value and health care function. It is a traditional health food and is deeply loved by consumers. my country is the first country in the world to cultivate lychees, with a long history; it is also the country with the largest production of lychees in the world, with various varieties. Litchi leaves are branches and leaves of litchi trees, which can be harvested throughout the year and are rich in resources. Studies have found that lychee core and lychee shell are rich in flavonoids, which have biological activities such as anti-oxidation, anti-cancer, and hypoglycemic....

Claims

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Application Information

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IPC IPC(8): C07C43/23C07C41/34
CPCC07C41/34C07C43/23
Inventor 杨宝蒋跃明温玲蓉
Owner SOUTH CHINA BOTANICAL GARDEN CHINESE ACADEMY OF SCI
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