Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition containing ezetimibe and atorvastatin calcium and preparation method of composition

A technology of atorvastatin calcium and ezetimibe, applied in the field of medicine, can solve the problems of high production cost, complicated process and high technical requirements of employees, and achieve the effects of reducing sensitivity, simple process operation and easy process operation.

Inactive Publication Date: 2014-09-03
AVENTIS PHARMA HAINAN
View PDF5 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In order to ensure stable quality, in the existing patents, the manufacturer mostly uses the double-layer tablet method to prepare it, but the process is complicated, requiring special production equipment, high technical requirements for employees, and high production costs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Tablet prescription:

[0030] Ezetimibe 10 g Atorvastatin Calcium Meglumine Mixed Powder 10 g anhydrous lactose 120 g sodium lauryl sulfate 2 g lactose monohydrate 55 g microcrystalline cellulose 30 g Croscarmellose Sodium 12 g povidone 4 g sodium bicarbonate 6 g hypromellose 5 g Magnesium stearate 2 g

[0031] Preparation Process:

[0032] (1) Micronize atorvastatin calcium and meglumine at a ratio of 5:1, and control the particle size at 60-100 μm; pass ezetimibe through a 80-100 mesh sieve, and set aside; lactose monohydrate, micro Crystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, anhydrous lactose, hypromellose, and sodium bicarbonate were passed through a 60-mesh sieve, and set aside;

[0033] (2) Add water to the prescription amount of povidone to make a 10% mass ratio adhesive, then add 10g ezetimibe, 55g lactose monohydrate, 2g sodium lauryl sulfate, 5g croscarmellose ...

Embodiment 2

[0037] Tablet prescription:

[0038] Ezetimibe 10 g Atorvastatin Calcium Meglumine Mixed Powder 20 g anhydrous lactose 130 g sodium lauryl sulfate 1 g lactose monohydrate 45 g microcrystalline cellulose 20 g Croscarmellose Sodium 12 g povidone 5 g sodium bicarbonate 9 g hypromellose 2 g Magnesium stearate 1 g

[0039] Preparation Process:

[0040] (1) Micronize atorvastatin calcium and meglumine at a ratio of 6:1, and control the particle size at 50-80 μm; pass ezetimibe through a 80-100 mesh sieve for use; Crystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, anhydrous lactose, hypromellose, and sodium bicarbonate were sieved separately, and set aside;

[0041] (2) Add water to the prescribed amount of povidone to make an 8% mass ratio adhesive, then add 10g ezetimibe, 45g lactose monohydrate, 1g sodium lauryl sulfate, 5g croscarmellose sodium Mix at a speed of 300 rpm, first stir for ...

Embodiment 3

[0045] Tablet prescription:

[0046] Ezetimibe 10 g Atorvastatin Calcium Meglumine Mixed Powder 40 g anhydrous lactose 150 g sodium lauryl sulfate 3 g lactose monohydrate 60 g microcrystalline cellulose 20 g Croscarmellose Sodium 12 g povidone 6 g sodium bicarbonate 12 g hypromellose 6 g Magnesium stearate 1 g

[0047] Preparation Process:

[0048] (1) Micronize atorvastatin calcium and meglumine at a ratio of 4:1, and control the particle size at 10-50 μm; pass ezetimibe through a 80-100 mesh sieve, and set aside; lactose monohydrate, micro Crystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, anhydrous lactose, hypromellose, and sodium bicarbonate were sieved separately, and set aside;

[0049] (2) Add water to the prescribed amount of povidone to make a 15% mass ratio adhesive, then add 10g ezetimibe, 60g lactose monohydrate, 3g sodium lauryl sulfate, 5g croscarmellose sodium Mixing ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a tablet composition containing ezetimibe and atorvastatin calcium and a preparation method of the composition. According to the method, the stability of atorvastatin calcium in a pharmaceutical composition can be effectively improved, and the in-vivo bioavailability of the medicine is improved. Moreover, the method has the advantages that the process is simple and feasible to operate, the requirement on preparation equipment is low, and the production cost is reduced. The solid oral preparation is used for treating or preventing cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a tablet for treating dyslipidemia, in particular to its prescription composition and preparation process, and belongs to the technical field of medicine. Background technique [0002] Coronary heart disease (CHD) is an important cause of disability and death in developed and developing countries, and it is also the main cause of late heart failure. Dyslipidemia has been recognized as a risk factor for cardiovascular disease and is one of the main risk factors for coronary heart disease. Low density lipoprotein cholesterol (LDL-C) is the most important pathogenic factor of CHD, and its plasma concentration Elevation was positively correlated with the risk of coronary heart disease. For high-risk groups with CHD and its equivalent risk diseases (diabetes), the optimal lipid-lowering target should be LDL-C ≤ 2.6mmol L-1, and for extremely high-risk groups (such as CHD complicated with diabetes, acute coronary syndrome) should be...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/40A61K9/36A61P3/06A61K31/397
Inventor 姚丽华郭夏
Owner AVENTIS PHARMA HAINAN
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com