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A kind of composite artificial ligament and its preparation method

A technology of artificial ligaments and tows, applied in ligaments, medical science, muscles, etc., can solve the problems of artificial ligaments elongation, poor biocompatibility, easy fatigue and fracture, and achieve the effect of promoting growth

Active Publication Date: 2016-03-30
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such materials are often accompanied by some defects: the material is not degradable and absorbable, and the wear debris of the artificial ligament can cause iatrogenic joint disease; the biocompatibility is not good, the cells and tissues on the surface of the ligament cannot grow normally, and it is easy to cause foreign body rejection; The artificial material has high hardness, no periodic relaxation, and is prone to fatigue and fracture; with the creep of the active ligament in the joint, the artificial ligament will be permanently elongated, resulting in instability of the knee joint
In addition, although some artificial ligaments have mesh, surrounding cells and tissues can grow into them, but before the artificial ligament breaks, the tissue that grows into the mesh of the artificial ligament will never be stimulated by normal stress and will not become a normal ligament at all. Tissue, once the artificial ligament is broken, it will be found that the tissue growing into the mesh is too soft and too elastic to maintain the function of the anterior cruciate ligament
These defects lead to the problem that the artificial ligament cannot be used for a long time
At present, artificial ligaments provided by the invention of artificial ligaments are mostly band-shaped or tubular. Although these two structures are simple in structure, their mechanical properties and degradation properties are often difficult to meet the requirements of ligaments.

Method used

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  • A kind of composite artificial ligament and its preparation method
  • A kind of composite artificial ligament and its preparation method
  • A kind of composite artificial ligament and its preparation method

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preparation example Construction

[0036] In the preparation method of the present invention, several components are sequentially spun or bundled, compounded into threads, woven into nets, rolled into rods and reinforced with non-woven needle punching technology, so that even in the degradation process , the structure of the product still maintains a mesh shape, and the mesh holes gradually become larger, which is more suitable for the attachment of surrounding tissues and the repair and growth of ligament tissues.

[0037] The semi-degradable composite artificial ligament of the present invention is composed of three components with different degradation properties, component one, component two and component three, through spinning or spinning, compounding into wires, weaving into nets, rolling the nets into rods and using Reinforced by spinning needle punching technology. Composite artificial ligament of the present invention, its preparation method is specifically as follows:

[0038] a. Spinning: spinning ...

Embodiment 1

[0048] Collagen and poly(ε-caprolactone) are selected as two raw materials, which are spun into silk or bundles by the preparation method of surgical suture, and polyethylene terephthalate is spun by melt spinning method. Filamentous or fascicled, where the diameter of a single filament is 1-50 μm, and the number of filaments contained in a single bundle is 1-20.

[0049] The three component tows are prepared according to the number ratio of 1:1:1, and the three-component tow is used as the inner core, and the first and second component tows are intertwined on the inner core, and passed through the web forming machine Weave the thread into a mesh structure with a mesh diameter ranging from 150 to 300 μm, and finally roll the mesh structure into a rod-shaped structure with a diameter of 6 mm, and use non-woven needle punching technology to make the threads in the rod-shaped structure entangled and entangled to form a mesh. Staggered structure.

[0050] The initial tensile stre...

Embodiment 2

[0052] Two raw materials, polyglycolic acid and poly-β-hydroxybutyrate, are selected to be spun into filaments or bundles by the preparation method of surgical sutures, and ultra-high molecular weight polyethylene is selected to be spun into filaments or bundles by melt spinning. In the form of a bundle, the diameter of the single filament is 1-50 μm, and the number of filaments contained in a single bundle is 1-20.

[0053] The three component tows are prepared according to the number ratio of 1:1:2, and the three-component tow is used as the inner core, and the first and second component tows are intertwined on the inner core, and passed through the web forming machine Weave the thread into a mesh structure with a mesh diameter of 150-300 μm, and finally roll the mesh structure into a rod-shaped structure with a diameter of 10 mm, and use non-woven needle punching technology to make the threads in the rod-shaped structure entangled and entangled to form a mesh. Staggered str...

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Abstract

The invention relates to a composite artificial ligament and a preparation method thereof. The composite artificial ligament has a rod-shaped structure, and the rod-shaped structure is rolled from a braided net; the braided net is a net-like structure woven from wires, and the rod-shaped The wires in the structure are entangled and entangled with each other to form a mesh interlaced structure; the wires are wound from several kinds of tows with different degradation properties, and the several kinds of tows with different degradation properties are degraded by different The performance components are respectively formed by spinning or spinning, so that the composite artificial ligament has gradient degradation performance. The composite artificial ligament of the present invention has good mechanical properties, can promote the attachment of surrounding tissues and the repair and normal growth of ligament tissue, and at the same time, some components in the body can be gradually biodegraded, and the degradation does not cause a significant decrease in the mechanical properties of the ligament.

Description

technical field [0001] The invention relates to the technical field of implantable medical devices, in particular to a composite artificial ligament and a preparation method thereof. Background technique [0002] Due to the special biological environment in the knee joint and the limitation of the blood supply of the cruciate ligament, the body of the cruciate ligament has no natural healing ability after rupture, so ligament reconstruction is required. Restorative materials include autografts, allografts, and artificial ligaments. Autologous transplantation has problems such as insufficient donor site and donor site complications, and allogeneic transplantation has the risk of delayed ligamentization, immune rejection, and even the risk of disease transmission. In contrast, artificial ligaments have the advantages of simple operation, reliable and controllable material sources, no damage to autologous tissue, and good postoperative stability, and are more widely used in li...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/24A61L27/22A61L27/20A61L27/18A61L27/16A61F2/08
Inventor 谭荣伟许孟强魏欣苗
Owner SHENZHEN LANDO BIOMATERIALS