Surface-modified radiofrequency ablation needle and its application

A technology of radiofrequency ablation and surface modification, applied in the field of tumor treatment, can solve the problems of poor surface smoothness of radiofrequency needles, poor material, poor elasticity and toughness, and affect medical safety, and achieve low friction, high hardness, and good blood compatibility sexual effect

Inactive Publication Date: 2016-02-24
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Traditional radio frequency needles have the following deficiencies: poor material, elasticity, and toughness, poor surface smoothness of radio frequency needles, and high frictional resistance; rough surface and complications such as pneumothorax and hemopneumothorax during treatment, which are serious Affect medical safety, etc.

Method used

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  • Surface-modified radiofrequency ablation needle and its application
  • Surface-modified radiofrequency ablation needle and its application
  • Surface-modified radiofrequency ablation needle and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Conductive layer: The needle tip of the radiofrequency ablation needle is modified with nanometer materials by ion implantation modification.

[0033] The needle tip of the radiofrequency ablation needle (16.65 cm in length, 18 G in diameter, 12.45 cm in length of the needle shaft, and 3 cm in length of the needle tip) was placed in the hollow space of a double-bend magnetic filter cathodic arc composite magnetron sputtering coating device (purchased from Ningbo Institute of Materials, Chinese Academy of Sciences). In the chamber, vacuumize, and then pass the acetylene gas with a flow rate of 20 sccm into the hollow chamber where the needle tip of the radio frequency ablation needle is placed through the ion source, and the ion source current is 0.10A, and then use titanium as the sputtering target material to inject into the sputtering target Introduce argon gas, the flow rate of argon gas is 40sccm, the argon gas sputtering current is 2A, the bias voltage is -100V,...

Embodiment 2

[0037] Change the argon flow in the Ti / DLC porous film formation process in step (1) of Example 1 to 20, 50, and 100ml / min respectively, and other operations are the same as in Example 1 to obtain a Ti with a thickness of 4 to 5 μm and a surface pore size of 600 to 800 nm. / DLC porous film layer, detecting the changes in the tetrahedral amorphous carbon film structure and friction properties of the Ti / DLC porous film prepared under different Ar flow conditions ( figure 2 ), the change of membrane stress ( image 3 ), and the change in the average coefficient of friction ( Figure 4 ).

[0038] (1) Tetrahedral amorphous carbon film structure and friction properties

[0039] The roughness and thickness of the film were characterized by a surface profiler (KLaTencorAlpha-StepIQ, ScientechCo., USA). The friction performance decreased gradually from 9.5nm / min at 20ml / minAr flow rate to 8.2nm / min at 100ml / minAr flow rate, and as the Ar flow rate increased, the surface roughness ...

Embodiment 3

[0047] Embodiment 3 antibacterial properties

[0048] 1. Materials

[0049] Strains: Staphyloccocus aureus (Staphyloccocusaureus), Candida albicans (C.albicans), Escherichia coli (Escherichiacoli) were purchased from Beijing National Institute for the Control of Pharmaceutical and Biological Products (National Institute for the Control of Pharmaceutical and Biological Products, NICPBP).

[0050] Conductive nanometer surface modification material Ti / Ti-DLC porous membrane: prepare a Ti / Ti-DLC porous membrane with a thickness of 4 to 5 μm and a surface pore diameter of 600 to 800 nm according to the method of the conductive layer in step (1) of Example 1, and mix Ti / Ti-DLC porous membrane is sprayed on the surface of stainless steel cylinder (1.5*2*2cm size, Figure 7 shown in B).

[0051] Non-conductive nano-surface modification material Ti / DLC composite layer: according to the method for the non-conductive layer in the embodiment 1 step (2), prepare the non-conductive nano-...

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Abstract

The invention discloses a surface modified radio frequency ablation needle and application thereof to preparation of radiofrequency ablation therapy instrument for treating tumor. A Ti / Ti DLC porous film with thickness of 4-5 m and surface pore size of 600-800 nm is formed on the surface of the needle tip of the radiofrequency ablation needle, and a Ti / DLC composite layer with thickness of 4-5 m and surface pore size of 600-800nm is formed on the needle rod end. The invention utilizes the characteristics of low friction, high hardness and good blood compatibility of the carbon film to modify the radiofrequency ablation needle surface; and through study on antibacterial property and tissue compatibility of the nano surface modified material, a nano material capable of significantly reducing the surface resistance of the radiofrequency ablation needle and reducing the adhesion and infection of the needle tip with surrounding tissues is selected, thereby greatly reducing the incidence rate of complications such as pneumothorax and haemopneumothorax, improving the overall performance of the radio frequency needle, and improving clinical curative effect.

Description

(1) Technical field [0001] The invention relates to a nano-material surface coating modified radiofrequency ablation treatment needle. The metal-doped DLC conductive coating is deposited on the needle tip, and the DLC insulating coating is deposited on the needle shaft, and the antibacterial properties, friction coefficient and tissue phase of the nano-material are studied. Capacitive application, so that it can be applied to tumor therapy. (2) Background technology [0002] Lung cancer has become the malignant tumor with the highest morbidity and mortality in my country. Lung cancer patients are old and often combined with severe diseases such as emphysema. About 20-30% of patients cannot tolerate surgery, chemotherapy, and radiotherapy, and a large number of cases give up treatment after radiotherapy and chemotherapy fail, and another 20% of malignant tumors will occur in the lungs. Metastasis, these require local minimally invasive treatment. Radiofrequency ablation (Ra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C14/35C23C14/46A61B18/12
Inventor 方勇王章桂韩卫东潘宏铭
Owner ZHEJIANG UNIV
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