A kind of wall-breaking preparation of breviscapine

A preparation technology of Erigeron breviscapus, which is applied in the field of wall-broken preparations of Erigeron breviscapus, can solve the problems of loss of active ingredients, poor thermal stability, easy moisture absorption, etc., achieve good disintegration and stability, and improve the utilization rate of active ingredients , The effect of simple granulation process

Active Publication Date: 2018-08-21
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its main components include phytosterols, gums (including galactose), glycoside resins, glycoside tannins, volatile oils (limonene, etc.), pyrocatechol, amino acid , sugar, etc., relatively sensitive to temperature, poor thermal stability
Therefore, if the traditional decocting method is used, on the one hand, it is easy to destroy its heat-sensitive components, and on the other hand, the decoction of the active ingredients is not complete, resulting in the loss of the active ingredients.
The preparation of scutellaria scutellaria into superfine powder of scutellaria breviscens helps to improve the utilization rate of active ingredients, but at the same time, due to the increase of the specific surface area of ​​the powder, it has the disadvantages of easy moisture absorption, oxidation, deterioration, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]Take the medicinal material of Erigeron lanceolata, coarsely pulverize it into a coarse powder of about 100 meshes, and then ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 41 μm, add ethanol-water solution (the mass fraction of ethanol is 20%) ) soft material by wet method, the ratio of solution to superfine powder is 0.5:1 (by weight), after mixing, pre-installed 20-mesh sieve, the extrusion speed is 50r / min, and the extrusion force is 1MPa to make wet granules. The wet granules were transferred to a hot air circulation oven, the drying temperature was set at 80°C, and dried for 2.5 hours until dry.

[0039]

[0040] Note: The full score is 10.

Embodiment 2

[0042] Take the medicinal material of Erigeron lanceolata, coarsely pulverize it into a coarse powder of about 100 meshes, and then ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 41 μm, and add ethanol-water solution (the mass fraction of ethanol is 30% ) soft material by wet method, the ratio of solution to superfine powder is 0.6:1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 55r / min, and the extrusion force is 0.8MPa to make wet granules , the wet granules were placed in a vacuum microwave drying oven, the drying temperature was set at 45°C, and dried for 0.75h until dry.

[0043]

[0044] Note: The full score is 10.

Embodiment 3

[0046] Take the medicinal material of Erigeron lanceolata, coarsely pulverize it into a coarse powder of about 100 meshes, and then ultrafinely pulverize it into a powder with a particle size of 90% or less than 41 μm in the ultrafine powder, add ethanol-water solution (the mass fraction of ethanol is 40% ) soft material by wet method, the ratio of solution to superfine powder is 0.7:1 (by weight), after mixing, pre-installed with a 30-mesh sieve, the extrusion speed is 80r / min, and the extrusion force is 0.3MPa to make wet granules , the wet granules were placed in a hot air circulation oven, the drying temperature was set at 80°C, and dried for 2.5 hours until dry.

[0047]

[0048] Note: The full score is 10.

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Abstract

The invention relates to the technical field of Chinese herbal preparations, specifically to a wall-broken Erigeron breviscapus preparation. A preparation method for the wall-broken Erigeron breviscapus preparation comprises the following steps: crushing Erigeron breviscapus into wall-broken powder; then carrying out ethanol-water wet granulation by controlling the mass of an ethanol solution and the wall-broken powder; carrying out extrusion forming at a certain rotating speed; and then carrying out drying. The preparation method has a high granulation rate; and the prepared wall-broken Erigeron breviscapus preparation has high bioavailability, good stability and good disintegration performance.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a wall-broken preparation of scutellaria breviscapine. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality increases the efficacy. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/10A61K36/28A61K9/16A61J3/00
Inventor 成金乐陈勇军徐吉银陈金梅梁学良
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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