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Wall-broken Dangshen preparation

A technology of Codonopsis pilosula and preparations, which is applied in the field of Codonopsis pilosula-broken preparations, which can solve the problems of easy loss of drug efficacy, low stability, easy moisture absorption and oxidation of broken-wall powders, and achieve moisture absorption that is not easy, good stability, and easy moisture absorption Effect

Active Publication Date: 2014-09-24
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defects in the prior art that the broken wall powder is easy to absorb moisture and be oxidized, the stability is not high, and the drug effect is easily lost, and a kind of Codonopsis pilosula broken wall preparation is provided

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take the medicinal material of Codonopsis pilosula, coarsely pulverize it into a coarse powder of about 100 meshes, and ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 38 μm, and add ethanol-water solution (the mass fraction of ethanol is 60% ) soft material by wet method, the ratio of solution to superfine powder is 0.3:1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 50r / min, and the extrusion force is 1MPa to make wet granules , the wet granules were placed in a hot air circulation oven, the drying temperature was set at 75°C, and dried for 3.5 hours until dry.

[0028]

[0029] Note: The full score is 10.

Embodiment 2

[0031] Take the medicinal material of Codonopsis pilosula, coarsely pulverize it into a coarse powder of about 100 meshes, and ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 38 μm, and add ethanol-water solution (the mass fraction of ethanol is 60% ) soft material by wet method, the ratio of solution to superfine powder is 0.5:1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 50r / min, and the extrusion force is 1MPa to make wet granules , the wet granules were transposed into a vacuum microwave drying oven, the drying temperature was set at 45°C, and dried for 0.75h until dry.

[0032]

[0033] Note: The full score is 10.

Embodiment 3

[0035] Take the medicinal material of Codonopsis pilosula, coarsely crush it into a coarse powder of about 100 mesh, and then ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 38 μm, add ethanol-water solution (the mass fraction of ethanol is 95%) ) soft material by wet method, the ratio of solution to ultra-fine powder is 0.6:1 (by weight), after mixing, pre-installed 30 mesh sieve, the extrusion speed is 80r / min, and the extrusion force is 0.3MPa to make wet Granules, wet granules are transferred to a hot air circulation oven, set the drying temperature to 60°C, and dried for 3.5 hours until dry, and after the granules are sized and sieved, the Codonopsis pilosula wall-broken preparation is obtained.

[0036]

[0037] Note: The full score is 10.

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Abstract

The invention relates to the technical field of Chinese herbal preparations, specifically to a wall-broken Dangshen preparation. The wall-broken Dangshen preparation is prepared by crushing Dangshen into wall-broken powder, then carrying out ethanol-water wet granulation, carrying out extrusion forming at a certain rotating speed and then carrying out drying. The prepared wall-broken Dangshen preparation has high bioavailability, good stability and good disintegration performance.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a wall-breaking preparation of Codonopsis pilosula. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality increases the e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/344A61K47/10A61K9/16A61J3/00
Inventor 成金乐陈勇军苏观凤彭丽华陈金梅
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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