Benzimidazole zinc complex and preparation method thereof

A technology of zinc benzimidazole and benzimidazole, which is applied in the field of metal complex antitumor drugs, can solve the problems of being difficult to meet the clinical needs of the treatment of esophageal cancer, prone to drug resistance, and many adverse reactions, and achieves the inhibition of esophageal cancer cells. Growth, good esophageal cancer cell growth inhibitory activity, easy post-treatment effect
CN104059092AInactive Publication Date: 2014-09-24ZHANJIANG NORMAL UNIV
2 Cites 10 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHANJIANG NORMAL UNIV
Publication Date
2014-09-24
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a benzimidazole zinc complex and a preparation method thereof. A chemical name of the benzimidazole zinc complex is dichloro-2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole zinc complex. The preparation method includes following steps: mixing 2-(carboxymethyl)benzoic acid with o-phenylenediamine, placing the mixture in phosphoric acid, performing a heating process at 180 DEG C for 3 hours to obtain a purple-green reactant, cooling the reactant to room temperature, adding distilled water, performing a neutralization reaction to obtain a yellow-green solid, performing a washing process through distilled water for three times, carrying out a filtering process, carrying out a recrystallization process through alcohol to obtain a yellow-green solid 2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole, namely a ligand, dissolving ZnCl2 and the ligand 2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole in a proper amount of a DMF solvent to obtain a mixture, stirring the mixture uniformly at room temperature, performing a volatilization process for seven days to obtain a slight yellow-green block-shaped complex monocrystal. The complex employs biological non-toxic element zinc as a metal ion, can be used for preparing antitumor drugs, can inhibit generation of esophagus cancer cells, and is free from remaining in human body and causing poisoning in human body due to metal accumulation. The complex is simple in the preparation method, is high in yield, is low in cost and is suitable for an industrial production.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a complex and a preparation method thereof, in particular to a benzimidazole zinc complex with antitumor effect and a preparation method thereof, belonging to the technical field of metal complex antitumor drugs. Background technique

[0002] Esophageal cancer is a malignant tumor occurring in the esophageal epithelium, which seriously threatens human health. Esophageal cancer is the fourth most deadly tumor in my country, accounting for 5.5% of the death toll (Chen Wanqing, Zhang Siwei, Zheng Rongshou et al. China Oncology, 2011, 03: 162-9). Since most patients in the early stage have no obvious symptoms, more than 95% of the first clinically diagnosed esophageal cancer patients are in the middle and advanced stages. At present, chemotherapy is the main and most effective method for the treatment of advanced esophageal cancer.

[0003] At the end of the 20th century, research on inorganic drugs has become a worldwide hotspot...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More