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Patch

一种贴剂、增粘剂的技术，应用在药物组合、油/脂肪/蜡非有效成分、神经系统疾病等方向，能够解决皮肤刺激性等问题，达到皮肤刺激性低、充分皮肤粘合性的效果

Active Publication Date: 2014-10-22
KM TRANSDERM LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] As a patch containing rivastigmine, there is disclosed a percutaneous absorption type preparation (Patent Document 1), which contains rivastigmine and an antioxidant in a matrix composed of polyacrylate or polymethacrylate; or Transdermal preparation (Patent Document 2) comprising a backing layer (carrier) containing polyacrylate, polymethacrylate, polyisobutylene, polybutylene, styrene-isoprene-styrene block The storage layer of rivastigmine such as a copolymer, and the adhesive layer containing a silicone polymer and a tackifier, but it is difficult to sufficiently solve the above-mentioned problem of skin irritation of a patch containing rivastigmine

Method used

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Examples

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Embodiment 1～10

[0135] [Example 1-10] Preparation of patch containing rivastigmine

[0136]Each component constituting the adhesive layer was weighed according to the recipe shown in Table 1. First, a styrene-isoprene-styrene block copolymer (SIS) / styrene-isoprene block copolymer (SI) mixture ("KRAYTON D1119" manufactured by KRAYTON Corporation (weight average molecular weight: 207500 ), "JSR SIS5505" and "JSR SIS5229" manufactured by JSR Corporation) were dissolved in 230 parts by weight of toluene with respect to 100 parts by weight of the mixture. Liquid paraffin ("KAYDOL", "Hydrobrite 550PO", "Hydrobrite HV" manufactured by Sonneborn) rivastigmine was added to the above solution, mixed and stirred to prepare a coating solution for forming an adhesive layer.

[0137] In addition, the above-mentioned coating solution was coated on a silicone-treated polyethylene terephthalate (PET) film to prepare (release liner), and the rivastigmine content in the dried adhesive layer was adjusted to 1....

Embodiment 11

[0212] [Example 11] Preparation of patch containing rivastigmine

[0213] According to the prescription shown in Table 8, each composition that constitutes the drug storage layer was weighed. First, a styrene-isoprene-styrene block copolymer (SIS) / styrene-isoprene block copolymer (SI) mixture ("KRAYTON D1119" manufactured by KRAYTON Corporation (weight average molecular weight: 207500 )) was dissolved in 230 parts by weight of toluene with respect to 100 parts by weight of the mixture. Liquid paraffin ("Hydrobrite HV" manufactured by Sonneborn Co., Ltd.) and rivastigmine were added to the above solution and mixed with stirring to prepare a coating solution for forming a drug storage layer.

[0214] Prepared by coating the above-mentioned coating solution on a silicone-treated polyethylene terephthalate (PET) film (release liner), so that the rivastigmine content in the dried drug storage layer was 1.8 mg / cm 2 . After drying in an oven at 80° C. for 1 hour, a PET film (car...

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Abstract

Provided is a patch which is formed with an adhesive layer that retains a medicine on a support, wherein the adhesive layer contains a thermoplastic elastomer, a non-volatile hydrocarbon oil in an amount of over 50 parts by weight and 800 parts by weight or less with respect to 100 parts by weight of the elastomer, and rivastigmine or a salt thereof, and may further contain a tackifier in an amount of 10 parts by weight or less of the adhesive layer.

Description

technical field [0001] The invention relates to a patch containing rivastigmine. More specifically, it relates to a patch having high skin permeability of rivastigmine, good transdermal absorbability, and low skin irritation. Background technique [0002] The characteristic of Alzheimer's dementia is that, in the cerebral cortex, due to the deposition of extracellular β-amyloid protein, it causes the death of nerve cells and the formation of neurofibrillary tangles and senile plaques, resulting in atrophy of the cerebral cortex, brain glucose Decreased utilization, decreased perfusion in the parietal, temporal cortex, prefrontal cortex, etc. cause progressive cognitive decline. Dementia patients are over 65 years old, generally about 5% of the population, and usually 40% of them are Alzheimer's type, and the number of patients with diseases that cause the disappearance and modification of nerve cells can be said to be in the future. increasingly serious disease in a modern...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/27A61K9/70A61K47/06A61K47/32A61K47/44A61P25/28A61P43/00
CPCA61K9/7023A61K47/44A61K47/06A61K31/27A61K47/32A61K9/7053A61K31/325A61P25/28A61P43/00A61K9/7038
Inventor 荻野弘幸后藤正兴滨田充代赤泽满儿行本定生
Owner KM TRANSDERM LTD
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