Rhodiola rosea extract, extraction method as well as application and product thereof in treatment/prevention of eye disease

An extraction method and extraction technology, applied to the extraction of active ingredients of natural plants and its application fields, can solve the problems of small adverse reactions, few complications, and low patient compliance

Inactive Publication Date: 2014-10-29
毕宏生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. Environmental factors: Long-term close-distance work, insufficient lighting in the working or reading environment, unstable gaze targets, VDT working environment, etc. can lead to adjustment tension and visual fatigue
[0019] In the field of treating visual fatigue, there are also some traditional Chinese medicine treatment methods, but they are all in the form of oral liquid, although they have certain curative effect, small adverse reactions and few complications.
However, there are still many defects such as low patient compliance, long treatment cycle, slow effect, large dosage, etc., especially among young people, and its popularization and application is low.
[0020] So far, the use of natural plant active ingredients to prepare specific eye patch formulations that can treat and / or improve eye diseases, and the extraction methods of specific active ingredients have not been reported.

Method used

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  • Rhodiola rosea extract, extraction method as well as application and product thereof in treatment/prevention of eye disease
  • Rhodiola rosea extract, extraction method as well as application and product thereof in treatment/prevention of eye disease
  • Rhodiola rosea extract, extraction method as well as application and product thereof in treatment/prevention of eye disease

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0086] Preparation Example 1: Preparation of Acidic Silica Gel

[0087] The neutral silica gel with a particle size of 200-300 mesh was placed in a muffle furnace at 650°C for 7 hours under vacuum, and then naturally cooled to room temperature to obtain activated neutral silica gel;

[0088] Concentrated sulfuric acid with a mass concentration of 98% was dropped into the above-mentioned activated neutral silica gel, the mass ratio of the activated neutral silica gel to concentrated sulfuric acid was 10:3, and then fully oscillated evenly to obtain acidic silica gel.

preparation example 2

[0089] Preparation Example 2: Preparation of Alkaline Silica Gel

[0090] The neutral silica gel with a particle size of 200-300 mesh was placed in a muffle furnace at 650°C for 7 hours under vacuum, and then naturally cooled to room temperature to obtain activated neutral silica gel;

[0091] Add the NaOH aqueous solution with a molar concentration of 2mol / L dropwise into the above-mentioned activated neutral silica gel, wherein the mass ratio of the activated neutral silica gel to the NaOH aqueous solution is 10:2, fully oscillate evenly, and then dry at 60°C for 90 minutes, Thus obtaining basic silica gel.

Embodiment 1

[0093] (1) Raw material processing to obtain raw material powder

[0094] Rhodiola rosea rhizomes were weighed, dried to constant weight, then pulverized, ground, and passed through a 50-mesh sieve to obtain raw material powder.

[0095] (2) The expansion system is extracted to obtain the initial extract extract

[0096] Add the raw material powder obtained in step (1) into isopropanol, then add carbon dioxide, seal and pressurize to 2Mpa to form an expansion solvent system, stir and extract at 50°C for 2 hours, release the pressure to normal pressure, and filter while hot, Concentrate the filtrate under reduced pressure to obtain the primary extract extract;

[0097] Wherein, the ratio of the raw material powder in gram (g) to the isopropanol in milliliter (ml) is 1:8; The ratio of carbon dioxide is 1:6.

[0098] (3) Liquid-liquid extraction of inorganic solution and organic solvent to obtain refined extract

[0099] The first extract extract of step (2) gained is 30% Na ...

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PUM

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Abstract

The invention relates to a rhodiola rosea extract, an extraction method thereof, application thereof to treatment / prevention of an eye disease and a product containing the extract. The extraction method comprises the following steps: (1) treating raw materials to obtain raw material powder; (2) extracting an expansion system to obtain a crude extract; (3) performing liquid-liquid extraction by using an inorganic solution and an organic solvent to obtain a refined extract; (4) performing column chromatography separation to obtain the rhodiola rosea extract. The extract has a good effect of treating / preventing eye diseases such as asthenopia, xerophthalmia and eye nerve pains and can be prepared into an eye pad form so that the extract is convenient to use, safe and nontoxic and has good application prospects and industrial potentiality in the clinic field.

Description

technical field [0001] The present invention relates to an active ingredient, an extraction method and its use and corresponding products of a precious Chinese medicinal material, more particularly to a Rhodiola rosea extract, its extraction method and its use in alleviating visual fatigue and its products, belonging to natural Plant active ingredient extraction and its application fields. Background technique [0002] In today's fast-paced modern life, eye disease is a common disease in the field of ophthalmology, and it is also a syndrome caused by the interweaving of eye or systemic organic factors and mental and psychological factors, such as eye pain , burning sensation, soreness, foreign body sensation, photophobia, tearing, blurred vision, dry eyes and double vision, and even headache, vomiting, nausea and other systemic symptoms, seriously affecting the quality of life of patients. [0003] With the development of society and changes in the social environment, the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61K9/70A61P27/02A61P25/00
Inventor 毕宏生宋继科郭俊国吴建峰解孝锋
Owner 毕宏生
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