Blood perfusion device for experimental animal

Abstract

The invention discloses a blood perfusion device for an experimental animal. The device comprises an artery indwelling needle, a three-way valve, a constant flow pump, a perfusion device, an evacuation air pipe, an infusion heater and a venous indwelling needle. The artery indwelling needle, the three-way valve, the constant flow pump, the perfusion device, the evacuation air pipe, the infusion heater and the venous indwelling needle are sequentially connected through catheters. A rabbit is adopted as the experimental animal, a vascular access is built through an ear central artery and an ear edge vein by local anaesthesia, the blood perfusion operation is simplified, the pain of the experimental animal is reduced, and the influence on the experiment result is reduced. The indwelling needles are soft, the inner wall of the blood vessel cannot be hurt, the indwelling needles can remain for a long time, and frequent blood perfusion is facilitated. The artery end is connected with the three-way valve to facilitate blood sampling and injection of anticoagulant and other drugs. The inner volume of the perfusion device is 20 ml, the reduction of the blood volume of the rabbit in the blood perfusion process does not obviously influence the basic vital signs, blood in the system is input back to the body of the animal through the constant flow pump after the perfusion is finished, and blood losses are reduced. The infusion heater is arranged at the vein end, compensates the loss of the temperature of the extracorporeal circulation blood, and keeps the temperature of the experimental animal constant.

Description

technical field [0001] The invention belongs to the field of medical equipment and relates to a blood perfusion device for experimental animals. Background technique [0002] Hemoperfusion (HP) is one of the commonly used blood purification methods in clinical practice. It draws the patient's blood from the body through puncture and other methods for extracorporeal circulation, and uses the adsorption of the adsorbent in the extracorporeal circulation perfusion device to remove exogenous blood. and blood purification treatment of endogenous toxins. Hemoperfusion for poisoning treatment generally uses activated charcoal or resin as the adsorbent material. Activated carbon is composed of criss-cross voids, and a large number of micropores constitute a huge specific surface area. The solute reaches the surface of activated carbon particles through the liquid phase, and then is adsorbed in the voids. This adsorption is non-specific and has a certain Adsorption. The resin main...

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Problems solved by technology

Due to the complex genetics and microbial background of hybrid dogs; and the high cost of experimental Beagle dogs and harsh breeding conditions, it is not convenient to use dogs as experimental animals to carry out experiments

There are also hemoperfusion experiments using rabbits as experimental animals. After general anesthesia, hemoperfusion is performed through carotid artery / venous cannulation. Surgery is required to separate the large blood vessels in the neck. The trauma is relatively large, the postoperative survival time is short, and the experimental operation is complicated.

General anesthesia drugs may also interfere with poison metabolism and hemoperfusion effect, affecting the objective evaluation of hemoperfusion effect

In addition, surgical wounds are prone to infection and bleeding, which increases the pain and accidental death of animals, increases the amount of animals used, and is also contrary to animal ethics and the "3R" principle

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