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Oral pharmaceutical composition for treating soft tissue injury and pharmaceutical purposes of oral pharmaceutical composition

A soft tissue injury and composition technology, which is applied in the field of Chinese herbal medicine extraction to achieve the effects of improving tissue blood supply, accelerating repair, and having obvious curative effects

Inactive Publication Date: 2014-11-05
西安唐王方兴制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report that water elm fruit or its extract has the effect of treating soft tissue injury

Method used

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  • Oral pharmaceutical composition for treating soft tissue injury and pharmaceutical purposes of oral pharmaceutical composition
  • Oral pharmaceutical composition for treating soft tissue injury and pharmaceutical purposes of oral pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of embodiment 1 water elm fruit n-butanol extract part

[0018] (1) Take 1050g of Shuiyuguo decoction pieces, add 10 times the amount of water, decoct 3 times, decoct for 1.5 hours for the first time, 1 hour for the second and third times, combine the decoction for 3 times, filter, and filtrate After being concentrated into a thick paste, it is dried below 80°C to form the water extract of the dry extract;

[0019] (2) Add 8 times the amount (v / w) of water-saturated n-butanol to the water extract part of the dry extract obtained in step (1), and continuously extract 2 times from the dry extract of the water extract with the reflux extraction method, Combine the extracts and filter to obtain the n-butanol extract, then recover the solvent under reduced pressure, dry it below 80°C to form a dry extract, grind it into fine powder, and pass through a 100-mesh sieve to obtain the n-butanol extract.

Embodiment 2

[0020] The preparation of embodiment 2 tablet

[0021]

[0022] Preparation process: Weigh 50g of the dry powder of the n-butanol extract of Shuiyu fruit prepared in Example 1, and 80g of starch, 50g of lactose and 15g of crospovidone in the prescription amount are respectively passed through a 100-mesh sieve, mixed evenly, and an appropriate amount of starch is added Make soft material after pulping, pass through a 20-mesh sieve to make wet granules, dry the wet granules fully at 55°C to obtain dry granules; mix the obtained dry granules with magnesium stearate, press 1000 tablets, and then coat with sugar.

Embodiment 3

[0023] Example 3 Observation of curative effect of water elm fruit extract on patients with acute blunt soft tissue injury

[0024] Forty-five patients with acute blunt soft tissue injury with onset within 3 days were divided into experimental group and control group according to the principle of random grouping, 23 cases in the experimental group, 14 males and 9 females, aged 18-62 years; 22 cases in the control group , 13 males and 9 females, aged l9-65 years old. Before treatment, the two groups were compared in terms of ecchymosis area, pain, tenderness, swelling, and dysfunction. After statistical processing, the difference was not statistically significant, and they were comparable.

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Abstract

The invention discloses an oral pharmaceutical composition for treating soft tissue injury and pharmaceutical purposes of the oral pharmaceutical composition. The composition is prepared from an active ingredient and pharmaceutically acceptable auxiliary materials, wherein the active ingredient is densehead mountainash fruit n-butyl alcohol extract. The contained active ingredient, namely the densehead mountainash fruit n-butyl alcohol extract, has the effect of improving hemodynamic indexes of blood stasis animals, blood circulation can be promoted, and tissue blood supply is improved, so that repair of injured tissues is accelerated, and the oral pharmaceutical composition is suitable to be developed into an oral medicine for treating acute closed soft tissue injury.

Description

technical field [0001] The invention belongs to the technical field of extraction of traditional Chinese medicinal materials, and relates to an oral pharmaceutical composition for treating soft tissue damage and its pharmaceutical application. Background technique [0002] After soft tissue injury, local capillaries rupture, blood circulation is destroyed, vascular permeability increases, and water, electrolytes, and plasma proteins infiltrate into the interstitial space. At the same time, neutrophils and monocytes escape from blood vessels and enter the interstitial space. The injured part has clinical manifestations such as pain, swelling, and cyanosis. After the intravascular fluid seeps into the interstitial space, it causes blood rheological changes such as high viscosity, high coagulation, and high concentration. Inflammation causes ischemia and hypoxia of tissue cells, aggravates the degeneration and necrosis of tissue cells, and aggravates blood stasis. [0003] So...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P19/04A61P29/00
Inventor 王玉梅
Owner 西安唐王方兴制药有限公司
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