α, β unsaturated ketone compound containing benzo five-membered unsaturated heterocyclic structure and its preparation method and application

Abstract

The invention provides alpha, beta unsaturated ketone compounds containing benzo five-membered unsaturated heterocycle structures as well as a preparation method and an application and use of the compounds. The alpha, beta unsaturated ketone compounds containing the benzo five-membered unsaturated heterocycle structures have the structure of a formula (I). In addition, the invention further provides a method for preparing the compounds and a pharmaceutical composition containing the components as active components. In vitro activity tests show that the compounds provided by the invention show a remarkable inhibiting effect on tumor cells. Therefore, the invention lays a foundation for lucubrating and developing anti-tumor medicines in the future and meanwhile further provides a new technical means for treating tumor diseases.

Description

technical field [0001] The invention relates to a class of α, β unsaturated ketone compounds containing a benzo five-membered unsaturated heterocyclic structure or pharmaceutically acceptable salts thereof, and discloses that the α, β unsaturated ketones containing a benzo five-membered unsaturated heterocyclic structure The preparation method of a saturated ketone compound or a pharmaceutically acceptable salt thereof, and the present invention also relates to the application of the α, β unsaturated ketone compound or a pharmaceutically acceptable salt thereof containing a benzo five-membered unsaturated heterocyclic structure in antitumor and A pharmaceutical composition containing the compound as an active ingredient. Background technique [0002] In recent years, tumor chemotherapy has made considerable progress, and the survival time of cancer patients has been significantly prolonged. In particular, breakthroughs have been made in the treatment of leukemia and malignan...

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Problems solved by technology

[0004] Anti-tumor drugs are developing from traditional cytotoxic drugs to new anti-tumor drugs that target multi-link mechanisms. At present, new targets of anti-tumor effects and corresponding new anti-tumor agents or methods that are concerned at home and abroad are as follows: ① Cell signal transduction molecules as targets: including protein tyrosine kinase inhibitors, farnesyl transferase inhibitors, MAPK signal transduction pathway inhibitors, and cell cycle regulators; ② targeting new blood vessels: new angiogenesis Inhibitors; ③Reducing cancer cell shedding, adhesion and basement membrane degradation: anti-metastatic drugs; ④Targeting telomerase: telomerase inhibitors; ⑤For tumor cell drug resistance: drug resistance reversal agents; ⑥Promoting Differentiation of malignant cells to maturity: Differentiation inducer; ⑦Specific killing of cancer cells: (antibody or toxin) oriented therapy; ⑧Enhance the curative effect of radiotherapy and chemotherapy: Tumor treatment sensitizer; ⑨Improve or regulate the immune function of the body: Biological response regulation ⑩Aiming at oncogenes and tumor suppressor genes: gene therapy—introducing wild-type tumor suppressor genes, suicide genes, anti-drug resistance genes and antisense oligonucleotides, and tumor genetic engineering have made great progress, but Currently clinically used therapeutic drugs lack specificity and generally have serious side effects

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