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Rhizoma corydalis pain alleviating tablet and preparation method thereof

A technology of Yuanhu Zhitong Tablets and Hu Zhitong Tablets, which is applied in the direction of non-central analgesics, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve problems such as restrictions, adverse reaction applications, and analgesic addiction. Achieve the effects of improved disintegration performance, simple preparation method and high bioavailability

Active Publication Date: 2014-11-19
广西维威制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current application of analgesics is limited due to addiction and obvious adverse reactions, so finding a class of analgesics with high efficiency and low toxicity will have far-reaching clinical significance

Method used

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  • Rhizoma corydalis pain alleviating tablet and preparation method thereof
  • Rhizoma corydalis pain alleviating tablet and preparation method thereof
  • Rhizoma corydalis pain alleviating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Prescription: Vinegar Corydalis 445g, Angelica dahurica 223g, Magnesium Stearate 14g, Talcum Powder 8g, Syrup 25g, Lemon Yellow 2g, Chuanba 1g, 60% ethanol 2500g.

[0030] (1) Extraction: take 166g of Angelica dahurica, crush it into fine powder and pass through a 120 mesh sieve, and crush the remaining Angelica dahurica and vinegar Corydalis into coarse powder and pass through a 12 mesh sieve, soak in 1500g of %6 ethanol for 24 hours, heat and reflux for 3 hours, collect and extract Then add 1000g of 60% ethanol to heat and reflux for 2 hours, collect the extract, combine the secondary extract, filter, and the filtrate is concentrated into a thick paste with a relative density of 1.20g / cm 3 ;

[0031] (2) Granulation: add Angelica dahurica powder into a wet granulator and mix for 120 seconds, then add the above-mentioned thick paste into a wet granulator for high-speed cutting and granulation for 100 seconds, pass through a 16-mesh sieve, and send the prepared granules...

Embodiment 2

[0034] Prescription: Vinegar Corydalis 445g, Angelica dahurica 223g, magnesium stearate 20g, talcum powder 5g, syrup 20g, tartrazine 3g, Sichuan wax 2g, 60% ethanol 2500g.

[0035] (1) Extraction: Take 166g of Angelica dahurica, crush it into fine powder and pass it through a 120 mesh sieve, and crush the rest of Angelica dahurica and vinegar corydalis into a coarse powder, pass it through a 12 mesh sieve, soak in 1500g of 60% ethanol for 24 hours, heat and reflux for 3 hours, collect and extract Then add 1000g of 60% ethanol to heat and reflux for 2 hours, collect the extract, combine the secondary extract, filter, and the filtrate is concentrated into a thick paste (relative density is 1.20g / cm 3 );

[0036] (2) Granulation: add Angelica dahurica powder into a wet granulator and mix for 120 seconds, add the above-mentioned thick paste into a wet granulator for high-speed cutting and granulation for 110 seconds, sieve through a 16-mesh sieve, and send the prepared granules in...

Embodiment 3

[0039] Prescription: Vinegar Corydalis 445g, Angelica dahurica 223g, magnesium stearate 10g, talcum powder 10g, syrup 30g, tartrazine 1g, Sichuan wax 3g, 60% ethanol amount.

[0040] (1) Extraction: Take 166g of Angelica dahurica, crush it into fine powder and pass it through a 120 mesh sieve, and crush the rest of Angelica dahurica and vinegar corydalis into a coarse powder, pass it through a 12 mesh sieve, soak in 1500g of 60% ethanol for 24 hours, heat and reflux for 3 hours, collect and extract Then add 1000g of 60% ethanol to heat and reflux for 2 hours, collect the extract, combine the secondary extract, filter, and the filtrate is concentrated into a thick paste (relative density is 1.20g / cm 3 );

[0041](2) Granulation: add Angelica dahurica powder into a wet granulator and mix for 120 seconds, add the above-mentioned thick paste into a wet granulator for high-speed cutting and granulation for 120 seconds, sieve through a 16-mesh sieve, and send the prepared granules i...

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Abstract

The invention discloses a rhizoma corydalis pain alleviating tablet and a preparation method thereof, rhizoma corydalis pain alleviating tablet is made from the following medicinal materials and auxiliary materials: 300-600 parts of vinegar prepared rhizoma corydalis, 100-300 parts of radix angelicae, 10-20 parts of magnesium stearate, 5-12 parts of talcum powder, 20g-30g parts of syrup, 1-3 parts of lemon yellow, 1-3 parts of insect wax and a proper amount of 60% alcohol. The rhizoma corydalis pain alleviating tablet is high in stability, good in taste, convenient to take, and high in bioavailability, and the preparation method is simple and does not need any special equipment and is suitable for industrialized production.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to Yuanhu Zhitong Tablet and a preparation method thereof. Background technique [0002] Pain is a common symptom of clinical diseases. Severe pain not only brings pain and tension to patients, but also causes physiological dysfunction and even shock. Pain treatment is a key topic of medical research. Experts in the field of pharmacy have conducted all-round research and exploration on pain. The current application of analgesics is limited due to their addiction and obvious adverse reactions. Therefore, finding a class of analgesics with high efficiency and low toxicity will have profound clinical significance. [0003] Due to its definite curative effect and small side effects, traditional Chinese medicine has attracted widespread attention in the medical circles of various countries in recent years. As the birthplace of traditional Chinese medicine, my cou...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/36A61P29/00
Inventor 刘景萍刘全国陈克领林文君
Owner 广西维威制药有限公司
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