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Diclazuril solution and preparation method thereof

A technology of diclazuril and solution, applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, anti-infective drugs, etc. Effect

Active Publication Date: 2014-11-26
河南后羿制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a solution of diclazuril, which has good stability and solves the problem of poor curative effect when diclazuril is mixed with water or mixed with materials.

Method used

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  • Diclazuril solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The diclazuril solution of this embodiment consists of the following components in parts by weight: 1 g of diclazuril, 30 g of propylene glycol, 35 g of N-methylpyrrolidone, 10 g of absolute ethanol, 5 g of benzyl alcohol, 803 g of Tween, sulfur Sodium sulfosulfate 0.5g, water for injection 15g.

[0020] The preparation method of the diclazuril solution of the present embodiment comprises the following steps:

[0021] 1) Take 0.5g of sodium thiosulfate and dissolve it in 15g of water for injection to obtain mixture A;

[0022] 2) Mix 3g of Tween 80, 15g of propylene glycol and 20g of N-methylpyrrolidone and heat to 40°C, add 1g of diclazuril and stir evenly, then add 5g of benzyl alcohol, 15g of propylene glycol and 15g of N-methylpyrrolidone, Stir evenly and heat to 50°C to dissolve to obtain mixture B;

[0023] 3) After mixing mixture A and mixture B and stirring evenly, add 10g of absolute ethanol to obtain the product.

Embodiment 2

[0025] The diclazuril solution of this embodiment consists of the following components in parts by weight: 1 g of diclazuril, 40 g of propylene glycol, 40 g of N-methylpyrrolidone, 12 g of absolute ethanol, 10 g of benzyl alcohol, 804 g of Tween, and sodium sulfite 1g, 10g of water for injection.

[0026] The preparation method of the diclazuril solution of the present embodiment comprises the following steps:

[0027] 1) Take 1g of sodium sulfite and dissolve it in 10g of water for injection to obtain mixture A;

[0028] 2) Mix 4g of Tween 80, 20g of propylene glycol and 20g of N-methylpyrrolidone and heat to 50°C, add 1g of diclazuril and stir evenly, then add 10g of benzyl alcohol, 20g of propylene glycol and 20g of N-methylpyrrolidone, Stir evenly and heat to 55°C to dissolve to obtain mixture B;

[0029] 3) Mix mixture A and mixture B and stir evenly, then add 12g of absolute ethanol to obtain.

Embodiment 3

[0031] The diclazuril solution of this embodiment consists of the following components in parts by weight: 1 part of diclazuril, 35 parts of propylene glycol, 30 parts of N-methylpyrrolidone, 15 g of absolute ethanol, 8 g of benzyl alcohol, Tween 805g, disodium edetate 2g, water for injection 20g.

[0032] The preparation method of the diclazuril solution of the present embodiment comprises the following steps:

[0033] 1) Take 2g of disodium edetate, add 20g of water for injection to dissolve, and obtain mixture A;

[0034] 2) Mix 5g of Tween 80, 10g of propylene glycol and 15g of N-methylpyrrolidone and heat to 45°C, add 1g of diclazuril and stir evenly, then add 8g of benzyl alcohol, 25g of propylene glycol and 15g of N-methylpyrrolidone, Stir evenly and heat to 60°C to dissolve to obtain mixture B;

[0035] 3) After mixing mixture A and mixture B and stirring evenly, add 15g of absolute ethanol to obtain.

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Abstract

The invention discloses a diclazuril solution and a preparation method thereof. The diclazuril solution comprises, by weight, 1 part of diclazuril, 30-40 parts of propylene glycol, 30-40 parts of N-methyl-2-pyrrolidone, 10-15 parts of anhydrous ethanol, 5-10 parts of benzyl alcohol, 3-5 parts of tween 80, 0.5-2 parts of an antioxidant and 10-20 parts of water for injection. The diclazuril solution has the following advantages: diclazuril is uniformly dispersed in the solution, so the stability of a drug is improved; the diclazuril solution can be diluted with water without precipitation when in use, and uniform dispersion is easy when the diclazuril solution is mixed for use, so the drug can be sufficiently administrated by poultry to timely and effectively kill coccidium in the poultry, thereby a good treatment effect can be reached; and the bioavailability is high, so the waste of the drug is avoided, and the culturing cost is saved.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, in particular to a diclazuril solution and a preparation method of the diclazuril solution. Background technique [0002] Diclazuril is a triazine benzyl nitrile compound, which is a new type, highly effective, and low-toxic anticoccidiostat, widely used in the prevention and treatment of chicken coccidiosis, and can treat chicken tenderness, heap type, poisonous, Brucella, giant Eimeria Coccidia, etc. have an excellent killing effect. The antimicrobial index of diclazuril against the above five coccidia are 200, 200, 197, 193, 183 respectively. In the early stage of the first generation of schizonts, the coccidia oocysts are killed, and the peak period of the main action on coccidia varies with different species of coccidia. For example, the main action point on Eimeria tenella is in the second generation Sexual cycle of coccidia; but it is ineffective against Eimeria brucei schiz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/53A61K47/34A61P33/02
Inventor 董晓盈陈建晖李建正
Owner 河南后羿制药有限公司
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