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Irregular micro-gel preparation method based on liquid bridge phenomenon

An irregular, microgel technology, applied in chemical instruments and methods, colloidal chemistry, colloidal chemistry, etc., to achieve the effect of easy internal gradient and high throughput, not limited by materials, and adjustable in shape

Active Publication Date: 2014-11-26
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the liquid bridge phenomenon has not been exploited in the preparation of microgels

Method used

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  • Irregular micro-gel preparation method based on liquid bridge phenomenon
  • Irregular micro-gel preparation method based on liquid bridge phenomenon
  • Irregular micro-gel preparation method based on liquid bridge phenomenon

Examples

Experimental program
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Effect test

preparation example Construction

[0036] The irregular microgel preparation method based on the liquid bridge phenomenon provided by the invention, such as figure 1 As shown, there are first and second surface materials 1 and 2 in contact with the hydrogel precursor droplet 3, and the hydrogel precursor droplet 3 that can form a liquid bridge. The height of the stretched or compressed liquid bridge and the first and second surface materials can be adjusted by controlling the hydrophilicity and hydrophobicity of the first and second surface materials in contact with the hydrogel precursor droplet, and the volume size of the hydrogel precursor droplet. The shapes of different shapes of irregular microgels can be regulated. The specific steps are:

[0037] Step 1: Adopt a lifting mechanical platform that can control the tension or compression height of the liquid bridge, fix the first surface material 1 on the liftable end of the lifting mechanical platform, and fix the second surface material 2 on the fixed end...

Embodiment 1

[0049] Example 1 Schematic diagram of polyethylene glycol microgels prepared on glass surfaces on both upper and lower surfaces and numerical simulation results

[0050] Step 1: Fix two glass slides on the fixed end and the liftable end of the lifting mechanical platform, respectively, to ensure that the slides and the lifting mechanical platform are firmly fixed, and ensure that the two slides are completely horizontal.

[0051] Step 2: Weigh a certain amount of PEG1000 monomer, dissolve it in ultrapure water, and prepare a PEG solution with a mass concentration of 10%. Then add 2-hydroxy-2-methyl propiophenone (the mass is 0.5% of the PEG solution) into the prepared PEG solution, shake it sufficiently to make it mix evenly, and obtain the first mixed solution (hydrogel precursor solution). Use a micropipette to draw 2 μl of the first mixed solution, and slowly add it dropwise onto the glass slide below the lifting platform.

[0052] Step 3: Adjust the lifting mechanical pla...

Embodiment 2

[0054] Example 2 Schematic diagram and numerical simulation results of polyacrylamide microgels prepared on the surface of PMMA plates on the upper and lower surfaces

[0055] Step 1: Fix two PMMA boards on the fixed end and the liftable end of the lifting machinery platform respectively, to ensure that the PMMA board and the lifting machinery platform are firmly fixed, and to ensure that the two PMMA boards are completely level.

[0056] Step 2: Weigh acrylamide, methylene bisacrylamide and ammonium persulfate into a beaker, the mass ratio of methylene bisacrylamide to acrylamide is 0.00375:1, and the mass ratio of ammonium persulfate to acrylamide is 0.0175:1 , then add ultrapure water to make the concentration of acrylamide 0.2g / ml, stir to dissolve the solid, and finally add N,N,N',N'-tetramethyldiethylamine, the mass ratio of which to acrylamide is 0.0068:1, the second mixture was obtained after mixing. Use a micropipette to draw 1 μl of the second mixed solution (hydrog...

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Abstract

The invention discloses an irregular micro-gel preparation method based on a liquid bridge phenomenon. A height-controllable mechanical lifting platform is adopted, and surface materials with different hydrophilcity / hydrophobicity are fixedly arranged at the fixed end and the liftable end of the mechanical platform respectively. A certain volume of hydro-gel precursor solution is weighed by using a micropipette and is dropwise added between the two surface materials, and the hydro-gel precursor drops are stretched or compressed to form a liquid bridge. By adjusting the shapes of contact parts between the two surface materials and the drops, the material characteristics and the spacing between the two surfaces, liquid bridges with different target shapes can be obtained. The hydro-gel precursor drops with different characteristics can be solidified by using different physical and chemical cross-linking methods. The irregular micro-gel preparation method is simple, convenient and rapid, and is not limited by the materials; the shape is controllable; high-throughput and internal gradient liquid bridges can be directly formed by virtue of simple technical improvement; the irregular micro-gel preparation method is quite potential, and provides powerful support for preparation of a tissue engineering base structure unit in the future.

Description

technical field [0001] The invention relates to the technical field of microgel preparation, in particular to a method for preparing irregular microgel based on liquid bridge phenomenon. Background technique [0002] At present, microgels have been widely used in drug delivery, tissue engineering, biosensing, biological barcoding and other fields. The shape of a microgel, as an important parameter, can significantly affect its function. In order to better simulate the microstructural repeating units of different shapes that exist in abundance in nature, irregular microgels are an ideal solution. In fact, the human body itself has many irregular repeating structural units, such as liver, kidney, and lung. There are a large number of irregular repeating units, and through certain combinations, complex functions are realized. Similarly, constructing a precisely designed microgel matrix can be beneficial for many biological applications. [0003] Currently, many methods have ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/00
Inventor 王琳徐峰裘慕书卢天健
Owner XI AN JIAOTONG UNIV
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