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Cefcapene pivoxil hydrochloride composition

A technology of cefcapine hydrochloride and a composition, applied in the field of medicine, can solve the problems of unfavorable clinical drug use, slow drug effect, low drug effect, etc., and achieve the effect of benefiting the speed of effect and the therapeutic effect.

Inactive Publication Date: 2014-12-10
SICHUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dissolution is too low, the drug effect is slow, and the drug effect is low, which is not conducive to clinical drug use

Method used

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  • Cefcapene pivoxil hydrochloride composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A cefcapene hydrochloride composition comprises the following components by weight:

[0027] Cefcapene Proxil Hydrochloride 120

[0028] Starch 45

[0029] Hydroxypropyl Cellulose 22

[0030] Sodium carboxymethyl starch 8

[0031] Magnesium stearate 0.8

[0032] Pharmaceutical film coating premix excipients 3.

Embodiment 2

[0034] A cefcapene hydrochloride composition comprises the following components by weight:

[0035] Cefcapene Proxil Hydrochloride 150

[0036] Starch 40

[0037] Hydroxypropyl Cellulose 18

[0038] Sodium carboxymethyl starch 12

[0039] Magnesium Stearate 1.5

[0040] Pharmaceutical film coating premix excipients 9.

Embodiment 3

[0042] A cefcapene hydrochloride composition comprises the following components by weight:

[0043] Cefcapene Proxil Hydrochloride 126

[0044] Starch 42

[0045] Hydroxypropyl Cellulose 20

[0046] Sodium carboxymethyl starch 18

[0047] Magnesium Stearate 1.0

[0048] Pharmaceutical film coating premix excipients 4.

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Abstract

The invention discloses a cefcapene pivoxil hydrochloride composition which is obtained by tabletting cefcapene pivoxil hydrochloride, starch, hydroxy propyl cellulose, carboxymethyl starch sodium, magnesium stearate and medical film coating premixed excipients. The cefcapene pivoxil hydrochloride composition has the benefits that the dissolution of the cefcapene pivoxil hydrochloride composition reaches above 90 percent, the use effect of the cefcapene pivoxil hydrochloride composition is improved, and the utilization rate of drugs can be effectively improved.

Description

[0001] Technical field [0002] The present invention involves a pharmaceutical field and specificly involves a type of cephalosporin hydrochloride composition. Background technique [0003] Tooth tissue infection, periodontitis, etc.At present, hydrochloride is generally used for oral convenience.However, hydrochloride is slightly soluble in ethanol and is almost insoluble in water. How to increase its solubility and increase the solubility of tablets has always been a subject of close attention on pharmaceutical preparations. [0004] The name of the application number 20110035286.3 is the patent of the patent of the hydrochloride patent composition and its preparation method.Moxibly carboxyl cellulose sodium, carboxymethyl starch sodium plus microfana silicone and lubricant, the highest solution reached 79%.Excessive dissolution, slow effects, and low efficacy, low efficacy, is not conducive to clinical medication. Invention content [0005] The technical problem to be solved...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K31/546A61K47/38A61P31/04
Inventor 沈千万周璇刘萍
Owner SICHUAN PHARMA
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