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Preparation method for pediatric paracetamol

A technology of children's paracetamol Huang Namin granules and acetaminophen, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problem of artificial bezoar identification items that do not meet the requirements and are effective The ingredients are not easy to absorb and the utilization rate of raw materials is low, so as to achieve the effect of low production cost, reliable quality and improved utilization rate

Inactive Publication Date: 2014-12-10
安徽安科恒益药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the invention is to solve the problems that the produced artificial bezoar does not meet the requirements of the identification items, and there are many fine powder particles, low utilization rate of raw materials, and difficult absorption of active ingredients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 A preparation method of pediatric paracetamol huangnaramine granules, including main materials and auxiliary materials, the main materials include acetaminophen, artificial bezoar and chlorpheniramine maleate, and the auxiliary materials include sucrose powder, essence and purified water . Weigh the main ingredients and auxiliary materials, (by weight) take 2.5 parts of acetaminophen, 0.1 part of artificial bezoar, 0.06 part of chlorpheniramine maleate, 97 parts of sucrose powder, 5 parts of essence 2.7 purified water, and the acetyl Aminophenol, artificial bezoar, chlorpheniramine maleate and sucrose powder are mixed in a high-speed mixing granulator. After mixing, add essence and purified water to the mixed material and put it into a swinging granulator for granulation. After granulation, put Boiling granulator, and then screen the material taken out of the material boiling granulator. After adopting this embodiment, the number of fine particles is reduced ...

Embodiment 2

[0015] Example 2 A preparation method of pediatric paracetamol huangnaramine granules, including main materials and auxiliary materials, the main materials include acetaminophen, artificial bezoar and chlorpheniramine maleate, and the auxiliary materials include sucrose powder, essence and purified water . Weigh the main ingredients and auxiliary materials, (by weight) 2.3 parts of acetaminophen, 0.3 parts of artificial bezoar, 0.1 parts of chlorpheniramine maleate, 95 parts of sucrose powder, 2 parts of essence, 7 parts of purified water, Mix acetaminophen, artificial bezoar, chlorpheniramine maleate and sucrose powder in a high-speed mixing granulator. After mixing, add essence and purified water to the mixed material and put it into a swinging granulator for granulation. After granulation Put it into the boiling granulator, and then screen the material taken out of the material boiling granulator. After adopting this embodiment, the number of fine particles is reduced unde...

Embodiment 3

[0016] Embodiment 3: A kind of preparation method of infantile paracetamol Huang Namin granule, comprises main material and auxiliary material, and main material comprises acetaminophen, artificial bezoar and chlorpheniramine maleate, and auxiliary material comprises microcrystalline cellulose, chlorine Sodium acetate, tartaric acid and xylose. Weigh the main ingredients and auxiliary materials, (by weight) 2.7 parts of acetaminophen, 0.2 parts of artificial bezoar, 0.15 parts of chlorpheniramine maleate, 88 parts of sucrose powder, 3 parts of essence, 12 parts of purified water, 2 parts of microcrystalline cellulose, 0.7 parts of sodium chloroacetate, 3 parts of tartaric acid, 1 part of xylose, put acetaminophen, artificial bezoar, chlorpheniramine maleate and sucrose powder into a high-speed mixing granulator and mix them. Add auxiliary materials to the mixed material and put it into a swing granulator for granulation, and put it into a boiling granulator after granulation, ...

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Abstract

The invention discloses a preparation method for pediatric paracetamol. The pediatric paracetamol comprises main materials and auxiliary materials, and is characterized in that the main materials comprise acetaminophen, calculus bovis factitius and chlorpheniramine maleate; the auxiliary materials comprise sucrose powder, essence and purified water. The preparation method comprises the following steps: weighing the main materials and the auxiliary materials; putting acetaminophen, calculus bovis factitius, chlorpheniramine maleate and sucrose powder into a high-speed mixing granulator for mixing; adding the essence and the purified water into the mixed materials, and putting into a swing granulator for granulating; putting into a boiling granulator after granulating; screening materials taken out from the boiling granulator. According to the preparation method, a condition that the quantity of granule fine powder is reduced on the premise that the identification items of calculus bovis factitius accord with the requirements is guaranteed; the pediatric paracetamol prepared is reliable in quality, good in content uniformity and low in manufacturing cost, and the utilization rate of raw materials is improved.

Description

technical field [0001] The invention relates to a preparation method of Pediatric Aminophen Huang Namin Granules. Background technique [0002] Influenza is the modal disease of mankind, and therefore the medicine for treating cold can be said to be innumerable all over the world, emerge in an endless stream. As a large country with a population of 1.3 billion, our country has a huge cold medicine market, and our country has a traditional habit of using traditional Chinese medicine. There are more types of Chinese medicine, Western medicine and compound preparations for cold treatment than other countries. Pediatric paracetamol Huang Namin granule is an over-the-counter drug suitable for relieving fever, headache, sore limbs, sneezing, runny nose, nasal congestion, sore throat and other symptoms caused by common cold and influenza in children. It is mainly composed of acetaminophen Composed of phenol (paracetamol), chlorpheniramine maleate (chlorpheniramine) and artificial ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K9/16A61K47/26A61K47/38A61P11/00A61P31/16A61P29/00A61P11/02A61P11/04A61K31/4402A61K31/167
Inventor 朱卫兵姚勇周月萍张荣平
Owner 安徽安科恒益药业有限公司
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