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Application of cistanche phenylethanoid glycoside extractive to control altitude sickness

A technology of phenylethanol glycosides and extracts, applied in the field of pharmacology

Inactive Publication Date: 2014-12-10
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the effectiveness of Ginkgo biloba extract is still controversial, Acanthopanax injection is only suitable for the treatment of plateau hypotension

Method used

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  • Application of cistanche phenylethanoid glycoside extractive to control altitude sickness
  • Application of cistanche phenylethanoid glycoside extractive to control altitude sickness
  • Application of cistanche phenylethanoid glycoside extractive to control altitude sickness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Normal pressure hypoxia experiment in mice

[0027] Experimental animals: clean grade KM mice, weighing 18-22g, free to drink and eat, clean grade animals SPF laboratory adaptive feeding for 3 days, temperature (20±2)°C, humidity (60±5)%, 12h light cycle. Experimental instruments and reagents: 250mL jar, stopwatch, medical sodium lime (Shanghai Wusi Chemical Reagent Co., Ltd., 20121218), petroleum jelly, Rhodiola rosea oral liquid (Tibet Tibetan Medicine Group Co., Ltd., 120503, Zhunzi B20070002 ), Cistanche phenylethanol glycoside extract (Xinghui Tianli Pharmaceutical Co., Ltd., 120401)

[0028] experimental method:

[0029] (1) Select 50 Kunming mice of 18-22 g, half male and half female, purchased from the Experimental Animal Center of Xinjiang Medical University, the animal production license number is SCXK (new) 2011-0004, and the animal use license number is SYXK (new) 2011-0004. Randomized block method, balanced body weight and sex, were random...

Embodiment 2

[0040] Example 2: Effect of prophylactic administration of phenylethanol glycosides from Cistanche deserticola on model rats with high altitude cerebral edema

[0041] Table 2-1 Main Instruments

[0042]

[0043] Table 2-2 Main Reagents

[0044]

[0045]

[0046] Experimental Animals and Grouping

[0047] Wistar rats, SPF grade, half male and half female, weighing 180-220 g, were purchased from the Experimental Animal Center of Xinjiang Medical University, the animal production license number is SCXK (new) 2011-0004, and the animal use license number is SYXK (new) 2011 -0004. After equalizing body weight and sex by random block method, the rats were randomly divided into 6 groups: normal control group, high-altitude cerebral edema model group, low-dose phenylethanol glycosides group (75 mg / kg), medium-dose phenylethanol glycosides group (150 mg / kg). kg), Cistanche cistanche phenylethanol glycoside high-dose group (300mg / kg), Rhodiola rosea oral liquid group (1.78mL...

Embodiment 3

[0078] Example 3: Study on the preventive effect and mechanism of phenylethanol glycosides of Cistanche deserticola on high altitude pulmonary edema

[0079] Experimental animals and experimental equipment are the same as in Experimental Example 2, and the experimental reagents are the same except that AQP5 antibody (L4790, Santa Cruz Biotechnology) is used instead of AQP4.

[0080] Experimental Animals and Grouping

[0081] Wistar rats, SPF grade, half male and half female, weighing 180-220 g, were purchased from the Experimental Animal Center of Xinjiang Medical University, the animal production license number is SCXK (new) 2011-0004, and the animal use license number is SYXK (new) 2011- 0004. They were randomly divided into 6 groups: normal control group, model group, Dahua Rhodiola Oral Liquid group (1.78mL / kg), low-dose phenylethanol glycoside group from Cistanche deserticola (75mg / kg), medium-dose phenylethanol glycoside group from Cistanche deserticola (150mg / kg). kg)...

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Abstract

The invention discloses application of cistanche phenylethanoid glycoside extractive to control altitude sickness. According to the application, experiments prove that the cistanche phenylethanoid glycoside extractive enables an organism to adapt to plateau anoxic environment and prevent encephaledema and pneumonedema from generating through anti-anoxia, anti-inflammatory, anti-oxidative stress and adjusting of aquaporin expression. Additionally, therapy medicine-administration experiments prove that the cistanche phenylethanoid glycoside extractive is capable of reducing incidence rate of limbs edema of a mouse attacked by chronic altitude sickness and mortality, and is capable of effectively reducing the pulmonary artery high pressure and the ventricle hypertrophy degree of a mouse attacked by chronic altitude sickness, and improving cardiopulmonary pathology change. Correspondingly, the invention also discloses a pharmaceutical composition containing the cistanche phenylethanoid glycoside extractive and being capable of controlling altitude sickness.

Description

technical field [0001] The invention relates to the application of the phenylethanol glycoside extract of Cistanche deserticola in preventing and treating altitude sickness, and belongs to the field of pharmacology. Background technique [0002] my country is the country with the largest plateau area in the world, and the overall terrain of my country is high in the west and low in the east, making the national borders in the northwest and western borders mainly plateau terrain. The two autonomous regions of Xinjiang and Tibet account for more than 30% of my country's total area, are rich in resources, own a large part of my country's land border, and have an extremely important strategic position. Xinjiang and Tibet are extremely rich in mineral deposits and tourism resources. With the opening of the international land route, the energy development and tourism industry of the two places will achieve substantial development and become an important economic fulcrum. Vigorous...

Claims

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Application Information

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IPC IPC(8): A61K36/64A61P39/00A61K31/7032
Inventor 陶义存毛新民李琳琳骆新王烨靳春丽
Owner XINJIANG MEDICAL UNIV
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