Polyether sulfone/alginate composite hollow fiber membrane and preparation method thereof

A technology of alginate and polyethersulfone, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc. Ion adsorption, the effect of avoiding coagulation in vitro

Active Publication Date: 2014-12-10
SUZHOU JUN KANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrophilicity of polyethersulfone is not as good as that of cellulose acetate and other materials. When preparing polyethersulfone dialysis membranes, water-soluble polymers such as polyvinylpyrrolidone (PVP) are generally selected as porogens. However, due to water-soluble polymers such as PVP The substances will be partially or even completely removed during the washing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Preparation of spinning stock solution: After drying the polyethersulfone powder with a molecular weight of 70000, the ingredients and mass percentages are formulated as follows: 20% polyethersulfone, 75% dimethylacetamide, polyvinylpyrrolidone ( PVP-K30) 5%. Put the above raw materials into a container, heat to 50°C, stir and dissolve to make a polymer solution, filter, vacuum defoam for 5 hours, put it into a barrel with heating and heat preservation function, and keep the temperature at 50°C.

[0028] (2) Coagulation bath preparation: Dimethylacetamide and water are made into a spinning coagulation bath, the weight concentration of dimethylacetamide is 2%, and the temperature of the coagulation bath is 50°C; sodium alginate is added to the coagulation bath and stirred to dissolve , sodium alginate accounts for 6% of the total weight of the coagulation bath.

[0029] (3) Spinning: the spinning dope is extruded from the spinneret spinning the hollow fiber membrane...

Embodiment 2

[0032] (1) Preparation of spinning stock solution: After drying the polyethersulfone powder with a molecular weight of 80000, the ingredients and mass percentages are formulated as follows: polyethersulfone 18%, dimethyl sulfoxide 78%, polyvinylpyrrolidone ( PVP-K90) 5%. Add the above raw materials into a container, heat to 55°C, stir and dissolve to form a solution, filter the solution, vacuum defoam for 5 hours, add it to a barrel with heating and heat preservation function, and keep the temperature at 55°C.

[0033] (2) Coagulation bath preparation: dimethyl sulfoxide and water are made into a spinning coagulation bath, the weight percent concentration of dimethyl sulfoxide is 5%, and the coagulation bath temperature is 30°C; add sodium alginate to the coagulation bath and stir Dissolved, sodium alginate accounts for 15% of the total weight of the coagulation bath.

[0034] (3) Spinning: the spinning dope is extruded from a spinneret spinning a hollow fiber membrane, and t...

Embodiment 3

[0037] (1) Preparation of spinning stock solution: After drying the polyethersulfone powder with a molecular weight of 60,000, the ingredients and mass percentages are formulated as follows: 22% polyethersulfone, 72.5% dimethylacetamide, polyvinylpyrrolidone ( PVP-K30) 5.5%. Put the above raw materials into a container, heat to 50°C, stir and dissolve to make a solution, filter the solution, vacuum defoam for 5 hours, add it to a barrel with heating and heat preservation function, and keep the temperature at 50°C.

[0038] (2) Coagulation bath deployment: N-methyl-2-pyrrolidone and water are made into a spinning coagulation bath, the weight concentration of N-methyl-2-pyrrolidone is 2%, and the temperature of the coagulation bath is 50°C; Sodium is added into the coagulation bath to stir and dissolve, and sodium alginate accounts for 10% of the total weight of the coagulation bath.

[0039] (3) Spinning: the spinning dope is extruded from the spinneret spinning the hollow fib...

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PUM

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Abstract

The invention relates to a polyether sulfone/alginate composite hollow fiber membrane and a preparation method thereof. The composite hollow fiber membrane is composed of polyether sulfone and an alginate, wherein the polyether sulfone accounts for 85%-99% of the solid content of the hollow fiber membrane, while the alginate accounts for 1%-15% of the solid content of the hollow fiber membrane; the polyether sulfone is adopted as the network framework of a porous membrane, while the alginate forms a spongy reticular structure and embedded into macropores of the porous membrane. The composite hollow fiber membrane is prepared through the following steps: preparing a spinning solution by mixing the polyether sulfone with a pore-foaming agent and an organic solvent, extruding by use of a spinning jet, carrying out wet spinning or dry-wet spinning, curing in a coagulating bath containing a monovalent alginate to generate a hollow fiber membrane, next, treating the hollow fiber membrane by use of the aqueous solution of a bivalent metal salt, and then performing drawing, water washing and drying. The polyether sulfone/alginate composite hollow fiber membrane is capable of resisting steam sterilization, has high hydrophily and ion adsorptivity and is capable of adsorbing an anticoagulant so as to prevent phenomena such as coagulation in vitro during hemodialysis; the preparation method of the membrane is suitable for industrial production.

Description

technical field [0001] The invention relates to a composite hollow fiber membrane and a preparation method thereof, in particular to a polyethersulfone / alginate composite hollow fiber membrane for hemodialysis and a preparation method thereof. Background technique [0002] Hemodialysis has been developed for more than 90 years. Hemodialysis is to extract blood out of the body, remove metabolic waste and impurities in the blood through the dialysis membrane in the hemodialysis machine, and then transport the purified blood back to the body. The dialysis membrane is composed of countless roots Composed of hollow fibers, when blood flows through these hollow fibers, the electrolyte solution with a concentration similar to that located on the outer layer of the hollow fibers performs material exchange through diffusion / convection, thereby removing metabolic waste in the blood, maintaining electrolyte and acid-base balance, and removing Excess moisture. [0003] With the develop...

Claims

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Application Information

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IPC IPC(8): B01D71/68B01D69/08B01D67/00B01D69/12
Inventor 邢雪奎沈新元黄臣勇高庆丰张婷婷刘劲波
Owner SUZHOU JUN KANG MEDICAL TECH
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