Polyether sulfone/alginate composite hollow fiber membrane and preparation method thereof

Abstract

The invention relates to a polyether sulfone / alginate composite hollow fiber membrane and a preparation method thereof. The composite hollow fiber membrane is composed of polyether sulfone and an alginate, wherein the polyether sulfone accounts for 85%-99% of the solid content of the hollow fiber membrane, while the alginate accounts for 1%-15% of the solid content of the hollow fiber membrane; the polyether sulfone is adopted as the network framework of a porous membrane, while the alginate forms a spongy reticular structure and embedded into macropores of the porous membrane. The composite hollow fiber membrane is prepared through the following steps: preparing a spinning solution by mixing the polyether sulfone with a pore-foaming agent and an organic solvent, extruding by use of a spinning jet, carrying out wet spinning or dry-wet spinning, curing in a coagulating bath containing a monovalent alginate to generate a hollow fiber membrane, next, treating the hollow fiber membrane by use of the aqueous solution of a bivalent metal salt, and then performing drawing, water washing and drying. The polyether sulfone / alginate composite hollow fiber membrane is capable of resisting steam sterilization, has high hydrophily and ion adsorptivity and is capable of adsorbing an anticoagulant so as to prevent phenomena such as coagulation in vitro during hemodialysis; the preparation method of the membrane is suitable for industrial production.

Description

technical field [0001] The invention relates to a composite hollow fiber membrane and a preparation method thereof, in particular to a polyethersulfone / alginate composite hollow fiber membrane for hemodialysis and a preparation method thereof. Background technique [0002] Hemodialysis has been developed for more than 90 years. Hemodialysis is to extract blood out of the body, remove metabolic waste and impurities in the blood through the dialysis membrane in the hemodialysis machine, and then transport the purified blood back to the body. The dialysis membrane is composed of countless roots Composed of hollow fibers, when blood flows through these hollow fibers, the electrolyte solution with a concentration similar to that located on the outer layer of the hollow fibers performs material exchange through diffusion / convection, thereby removing metabolic waste in the blood, maintaining electrolyte and acid-base balance, and removing Excess moisture. [0003] With the develop...

AI Technical Summary

Problems solved by technology

However, the hydrophilicity of polyethersulfone is not as good as that of cellulose acetate and other materials. When preparing polyethersulfone dialysis membranes, water-soluble polymers such as polyvinylpyrrolidone (PVP) are generally selected as porogens. However, due to water-soluble polymers such as PVP The substances will be partially or even completely removed during the washing process of the membrane, so the hydrophilicity of the membrane is still not high

[0004] At the same time, although the structure and function of the current artificial kidney dialyzer have been greatly improved, it is still far from the function of the human kidney, especially some membrane materials will cause adverse effects such as blood coagulation in vitro during hemodialysis. event