Thermo-sensitive in-situ gel for articular cavity injection and preparation method thereof

A temperature-sensitive gel, joint cavity technology, applied in the field of medicine, can solve the problems of difficulty in use, short residence time, and no encapsulation of therapeutic drugs, etc.
CN104208014AInactive Publication Date: 2014-12-17JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2014-12-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention mainly provides thermo-sensitive in-situ gel for articular cavity injection and a preparation method thereof. The gel is prepared from a drug-loaded biodegradable high-molecular polymer in a physical crosslinking way. The high-molecular polymer is prepared by connecting hyaluronic acid and a temperature-sensitive material through chemical bonds; when the temperature is lower than the body temperature, the drug can be loaded or dispersed into the polymer to form a nanogel suspension; and the temperature of an articular cavity injection part is raised to the body temperature, the preparation is converted from the nano suspension to the in-situ gel. The gel provided by the invention is free of chemical crosslinking, high in safety and capable of taking the synergic treatment effects of a nonsteroidal anti-inflammatory drug and the hyaluronic acid, reducing the toxic and side effects and improving the compliance of a patient.
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Description

technical field

[0001] The invention belongs to the technical field of medicine and provides a temperature-sensitive in-situ gel for intra-articular injection and a preparation method thereof. Background technique

[0002] Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used in the treatment of arthritis, mainly by inhibiting cyclooxygenase (COX), thereby inhibiting the synthesis of prostaglandins to achieve anti-inflammatory and analgesic effects. However, the NSAIDs currently used clinically are mainly oral preparations, and patients are prone to gastrointestinal adverse reactions after long-term use, and there are certain damages to the liver, kidneys and cardiovascular system.

[0003] Intra-articular injection can directly act on the target site of the drug, increase the local concentration, avoid the physiological transport barrier in the body, change the distribution mode of the drug, exert the drug effect in a small dose, and reduce the toxic and side...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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