Avermectin suspension and preparation method thereof

A technology of abamectin and suspension, which is applied in liquid delivery, pharmaceutical formula, emulsion delivery, etc., can solve the problems of incomplete absorption of anthelmintic drugs, poor therapeutic effect, low bioavailability, etc. long-acting effect, easy operation, and high bioavailability

Inactive Publication Date: 2014-12-17
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a kind of abamectin suspension, solve the problems of incomplete absorption, low bioavailability and poor therapeutic effect of existing anthelmintic drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The abamectin suspension of the present embodiment contains the following components in every 100ml suspension: abamectin 3g, dehydrated alcohol 25g, polyethylene glycol 20020g, sodium carboxymethylcellulose 1.0g, gelatin 0.5g, Tween 801g, sodium benzoate 0.5g, and the balance is water for injection.

[0029] The preparation method of the Abamectin suspension of the present embodiment may further comprise the steps:

[0030] 1) Swell 1.0 g of sodium carboxymethylcellulose with 20 ml of water for injection to obtain mixture A;

[0031] 2) Add 0.5g of gelatin to 10ml of water for injection for emulsification to obtain mixture B;

[0032] 3) Mix mixture A and mixture B and stir evenly, then add 20g of polyethylene glycol 200 and 25g of absolute ethanol and stir evenly to obtain mixture C;

[0033] 4) Add 3g of avermectin to mixture C, stir evenly at 40°C, add 1g of Tween 80 for emulsification, make Tween 80 fully chelate with avermectin at 40°C, and then Add 0.5 g of so...

Embodiment 2

[0038] The abamectin suspension of the present embodiment contains the following components in every 100ml suspension: abamectin 1g, dehydrated alcohol 20g, polyethylene glycol 20025g, sodium carboxymethylcellulose 1.1g, gelatin 0.6g, Tween 801g, sodium benzoate 0.5g, and the balance is water for injection.

[0039] The preparation method of the Abamectin suspension of the present embodiment may further comprise the steps:

[0040] 1) Swell 1.1g of sodium carboxymethylcellulose with 20ml of water for injection to obtain mixture A;

[0041] 2) Add 0.6g of gelatin to 10ml of water for injection for emulsification to obtain mixture B;

[0042] 3) Mix mixture A and mixture B and stir evenly, then add 25g of polyethylene glycol 200 and 20g of absolute ethanol and stir evenly to obtain mixture C;

[0043] 4) Add 1g of avermectin to mixture C, stir evenly at 40°C, add 1g of Tween 80 for emulsification, make Tween 80 fully chelate with avermectin at 40°C, and then Add 0.5 g of sodi...

Embodiment 3

[0048] The abamectin suspension of the present embodiment contains the following components in every 100ml suspension: abamectin 2g, dehydrated alcohol 10g, polyethylene glycol 20015g, sodium carboxymethylcellulose 0.6g, gelatin 0.7g, Tween 801g, sodium benzoate 0.5g, and the balance is water for injection.

[0049] The preparation method of the Abamectin suspension of the present embodiment may further comprise the steps:

[0050] 1) Swell 0.6g of sodium carboxymethylcellulose with 20ml of water for injection to obtain mixture A;

[0051] 2) Add 0.7g of gelatin to 10ml of water for injection for emulsification to obtain mixture B;

[0052]3) Mix mixture A and mixture B and stir evenly, then add 15g of polyethylene glycol 200 and 10g of absolute ethanol and stir evenly to obtain mixture C;

[0053] 4) Add 2g of avermectin to mixture C, stir evenly at 40°C, add 1g of Tween 80 for emulsification, make Tween 80 fully chelate with avermectin at 40°C, and then Add 0.5 g of sodiu...

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Abstract

The invention discloses an avermectin suspension and a preparation method thereof. Each 100 mL of suspension comprises the following components by weight: 1 to 3 grams of avermectin, 10 to 25 grams of absolute ethanol, 15 to 25 grams of polyethylene glycol, 0.6 to 1.3 grams of sodium carboxymethylcellulose, 0.5 to 0.7 gram of gelatin, 1 gram of tween 80, 0.5 gram of sodium benzoate, and the balance being injection water. The avermectin suspension is prepared by compounding avermectin, absolute ethanol, polyethylene glycol, sodium carboxymethylcellulose, gelatin, tween 80, and sodium benzoate, and the components mentioned above cooperate with each other to generate a synergetic effect. The provided suspension solves the problem that avermectin is hard to dissolve, can be rapidly absorbed by the gastrointestinal tracts, is completely absorbed in human body, has a high bio-utilization degree and large divergence, improves the sustained releasing and long acting effect of active components, has a rapid effect and radical curative effect on nematodosis, mite diseases, parasitic insect diseases of poultry and livestock, does not generate any drug residue, and is easy to promote and use in clinic.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, in particular to an abamectin suspension, and also relates to a preparation method of the abamectin suspension. Background technique [0002] With the development of our country's economy and the improvement of people's living standards, the development speed of animal husbandry has been significantly accelerated, and its proportion in the social industrial structure is also increasing. have made great contributions. However, in most areas of our country, the livestock breeding process will be harmed by various diseases, most of which are caused by various parasites. [0003] Among all kinds of parasites, the digestive tract nematodes are an important class, mainly including the nematodes of the Trichocymaceae, Trichotraceae, and Strongyloides, including Haemonchus, Trichostrongylus, Osteria, Cooperiae, Marshall's nematodes, nematodes, etc. These parasites have been prevalent in di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/7048A61K47/42A61P33/10A61P33/14
CPCY02A40/70
Inventor 李建正董晓盈陈建晖
Owner ZHENGZHOU HOUYI PHARMA
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